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Typhoid Hepatitis With Immunoglobulins and Complement Deposits in Bile Canaliculi

Typhoid Hepatitis With Immunoglobulins and Complement Deposits in Bile Canaliculi Abstract • Documented typhoid fever in a 26-year-old patient was complicated by acute hepatitis with unusually profound jaundice. Liver biopsy revealed focal cell necrosis, mononuclear cell infiltration, Kupffer cell proliferation, and mild cholestasis. Immunofluorescent studies of the liver biopsy revealed deposits of IgG, IgA, IgM, and C3 in the bile canaliculi, suggesting a role for damage by immune complexes in typhoid hepatitis. (Arch Intern Med 1982;142:148-149) References 1. Ayhan A, Gokoz A, Karacadag S, et al: The liver in typhoid fever. Am J Gastroenterol 1973;59:141-146. 2. Ramachandran S, Godfrey JJ, Perera MVF: Typhoid hepatitis. JAMA 1974;230:236-240.Crossref 3. Le Van Diem, Tran Quang My, Nguyen Van Chi, et al: Typhoid fever with hepatitis. J Trop Med Hyg 1976;79:25-27. 4. Nasrallah SM, Nassar VH: Enteric fever. Am J Gastroenterol 1978;69:63-69. 5. Zimmerman HJ: Jaundice due to bacterial infection. Gastroenterology 1979;77:362-374. 6. Morgan HR: Pathological changes produced in rabbits by a toxic somatic antigen derived from Eberthella typhosa. Am J Pathol 1943;19:135-145. 7. Butler T, Bell WR, Levin J, et al: Typhoid fever: Studies of blood coagulation, bacteremia, and endotoxinemia. Arch Intern Med 1978;138:407-410.Crossref 8. De Brito T, Tench Vieira W, D'Agostino Dias M: Jaundice in typhoid hepatitis: A light and electron microscopy study based on liver biopsies. Acta Hepato-Gastroenterol 1977;24:426-433. 9. Duffy J, Lidsky MD, Sharp JT, et al: Polyarthritis, polyarteritis and hepatitis B. Medicine 1976;55:19-37.Crossref 10. Williams RC: Subacute bacterial endocarditis as an immune disease. Hosp Pract 1971;6:111-122. 11. Sitprija V, Pipatanagul V, Boonpucknavig V, et al: Glomerulitis in typhoid fever. Ann Intern Med 1974;81:210-213.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Typhoid Hepatitis With Immunoglobulins and Complement Deposits in Bile Canaliculi

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340140150027
Publisher site
See Article on Publisher Site

Abstract

Abstract • Documented typhoid fever in a 26-year-old patient was complicated by acute hepatitis with unusually profound jaundice. Liver biopsy revealed focal cell necrosis, mononuclear cell infiltration, Kupffer cell proliferation, and mild cholestasis. Immunofluorescent studies of the liver biopsy revealed deposits of IgG, IgA, IgM, and C3 in the bile canaliculi, suggesting a role for damage by immune complexes in typhoid hepatitis. (Arch Intern Med 1982;142:148-149) References 1. Ayhan A, Gokoz A, Karacadag S, et al: The liver in typhoid fever. Am J Gastroenterol 1973;59:141-146. 2. Ramachandran S, Godfrey JJ, Perera MVF: Typhoid hepatitis. JAMA 1974;230:236-240.Crossref 3. Le Van Diem, Tran Quang My, Nguyen Van Chi, et al: Typhoid fever with hepatitis. J Trop Med Hyg 1976;79:25-27. 4. Nasrallah SM, Nassar VH: Enteric fever. Am J Gastroenterol 1978;69:63-69. 5. Zimmerman HJ: Jaundice due to bacterial infection. Gastroenterology 1979;77:362-374. 6. Morgan HR: Pathological changes produced in rabbits by a toxic somatic antigen derived from Eberthella typhosa. Am J Pathol 1943;19:135-145. 7. Butler T, Bell WR, Levin J, et al: Typhoid fever: Studies of blood coagulation, bacteremia, and endotoxinemia. Arch Intern Med 1978;138:407-410.Crossref 8. De Brito T, Tench Vieira W, D'Agostino Dias M: Jaundice in typhoid hepatitis: A light and electron microscopy study based on liver biopsies. Acta Hepato-Gastroenterol 1977;24:426-433. 9. Duffy J, Lidsky MD, Sharp JT, et al: Polyarthritis, polyarteritis and hepatitis B. Medicine 1976;55:19-37.Crossref 10. Williams RC: Subacute bacterial endocarditis as an immune disease. Hosp Pract 1971;6:111-122. 11. Sitprija V, Pipatanagul V, Boonpucknavig V, et al: Glomerulitis in typhoid fever. Ann Intern Med 1974;81:210-213.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Jan 1, 1982

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