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Decreasing M Spike With Increasing Tumor Burden in Multiple Myeloma

Decreasing M Spike With Increasing Tumor Burden in Multiple Myeloma Abstract • In a patient with myeloma, the serum concentration of the monoclonal immunoglobulin usually bears a direct relationship with the tumor burden as the disease waxes and wanes. In three cases, the level of the monoclonal protein fell as the plasma cell mass increased. Possible explanations of this observation are discussed. (Arch Intern Med 1981;141:1152-1153) References 1. Salmon SE: Expansion of the growth fraction in multiple myeloma with alkylating agents. Blood 1975;44:119-129. 2. Salmon SE, Smith BA: Immunoglobulin synthesis and total body tumor cell number in IgG multiple myeloma. J Clin Invest 1970;49:1114-1121.Crossref 3. Salmon SE: Immunoglobulin synthesis and tumor kinetics and multiple myeloma. Semin Hematol 1973;10:135-147. 4. Killingsworth LM, Savory J: Automated immunochemical procedures for measurement of immunoglobulin G, A, and M in human serum. Clin Chem 1971;17:936-940. 5. Marby RT, Shelburne J, Cohen HJ: In vitro kinetics of immunoglobulin synthesis and secretion by non-secretory human myeloma cells. Blood 1977;50:1031-1038. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Decreasing M Spike With Increasing Tumor Burden in Multiple Myeloma

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1981.00340090048012
Publisher site
See Article on Publisher Site

Abstract

Abstract • In a patient with myeloma, the serum concentration of the monoclonal immunoglobulin usually bears a direct relationship with the tumor burden as the disease waxes and wanes. In three cases, the level of the monoclonal protein fell as the plasma cell mass increased. Possible explanations of this observation are discussed. (Arch Intern Med 1981;141:1152-1153) References 1. Salmon SE: Expansion of the growth fraction in multiple myeloma with alkylating agents. Blood 1975;44:119-129. 2. Salmon SE, Smith BA: Immunoglobulin synthesis and total body tumor cell number in IgG multiple myeloma. J Clin Invest 1970;49:1114-1121.Crossref 3. Salmon SE: Immunoglobulin synthesis and tumor kinetics and multiple myeloma. Semin Hematol 1973;10:135-147. 4. Killingsworth LM, Savory J: Automated immunochemical procedures for measurement of immunoglobulin G, A, and M in human serum. Clin Chem 1971;17:936-940. 5. Marby RT, Shelburne J, Cohen HJ: In vitro kinetics of immunoglobulin synthesis and secretion by non-secretory human myeloma cells. Blood 1977;50:1031-1038.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1981

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