Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Age as a Variable in Acetaminophen Overdose

Age as a Variable in Acetaminophen Overdose Abstract • More than 300 accidental ingestions of acetaminophen products in children 6 years of age and younger have been reported to the Rocky Mountain Poison Center, Denver, during September 1974 to September 1979. Few of these have resulted in toxic reactions, based on clinical examination of the children. This report documents 17 childhood ingestions of acetaminophen in which plasma levels of the substance were measured and liver function was evaluated. Thirteen of these cases occurred as a result of accidental ingestion by children 6 years of age or younger; five of these children had documented plasma levels that were in the toxic range of an adult nomogram and were treated with acetylcysteine. Only minor abnormalities in liver function were observed in the treated children, even when therapy was instituted as late as 20 hours after ingestion. (Arch Intern Med 1981;141:390-393) References 1. Arena JM, Rourk MH Jr, Sibrack CD: Acetaminophen: Report of an unusual poisoning. Pediatrics 1978;61:68-72. 2. Wilson JT, Kasantikul V, Harbison R, et al: Death in an adolescent following an overdose of acetaminophen and phenobarbital. Am J Dis Child 1978;132:466-473. 3. Cohen SB, Burk RF: Acetaminophen overdoses at a county hospital: A year's experience. South Med J 1978;71:1359-1363.Crossref 4. Levy G, Khanna NN, Soda DM, et al: Pharmacokinetics of acetaminophen in the human neonate: Formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion. Pediatrics 1975;55:818-825. 5. Windorfer A, Vogel C: Prospective clinical study on the bioavailability of therapeutic doses of acetaminophen in children, abstracted. Klin Paediatr 1976;188:430-434. 6. Miller RP, Roberts RJ, Fischer LJ: Acetaminophen elimination kinetics in neonates, children, and adults. Clin Pharmacol Ther 1976;19:284-294. 7. Alam SN, Roberts RJ, Fischer LJ: Age-related differences in salicylamide and acetaminophen conjugation in man. J Pediatr 1977;90:130-135.Crossref 8. Loughnan PM, Greenwald A, Purton WW, et al: Pharmacokinetic observations of phenytoin disposition in the newborn and young infant. Arch Dis Child 1977;52:302-309.Crossref 9. Beaudry PH, Brickman HF, Wise MB, et al: Liver enzyme disturbances during isoniazid chemoprophylaxis in children. Am Rev Respir Dis 1974;110:581-584. 10. Nogen AG, Bremmer JE: Fatal acetaminophen overdosage in a young child. J Pediatr 1978;92:832-833.Crossref 11. Rumack BH, Matthew H: Acetaminophen poisoning and toxicity. Pediatrics 1975;55:871-876. 12. Meredith TJ, Newman B, Goulding R: Paracetamol poisoning in children. Br Med J 1978;2:478-479.Crossref 13. Rumack BH, Peterson RG: Acetaminophen overdose: Incidence, diagnosis, and management in 416 patients. Pediatrics 1978;62( (suppl 2) ):898-903. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Age as a Variable in Acetaminophen Overdose

Loading next page...
 
/lp/american-medical-association/age-as-a-variable-in-acetaminophen-overdose-Hn0jxN7AM5

References (14)

Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1981.00340030122022
Publisher site
See Article on Publisher Site

Abstract

Abstract • More than 300 accidental ingestions of acetaminophen products in children 6 years of age and younger have been reported to the Rocky Mountain Poison Center, Denver, during September 1974 to September 1979. Few of these have resulted in toxic reactions, based on clinical examination of the children. This report documents 17 childhood ingestions of acetaminophen in which plasma levels of the substance were measured and liver function was evaluated. Thirteen of these cases occurred as a result of accidental ingestion by children 6 years of age or younger; five of these children had documented plasma levels that were in the toxic range of an adult nomogram and were treated with acetylcysteine. Only minor abnormalities in liver function were observed in the treated children, even when therapy was instituted as late as 20 hours after ingestion. (Arch Intern Med 1981;141:390-393) References 1. Arena JM, Rourk MH Jr, Sibrack CD: Acetaminophen: Report of an unusual poisoning. Pediatrics 1978;61:68-72. 2. Wilson JT, Kasantikul V, Harbison R, et al: Death in an adolescent following an overdose of acetaminophen and phenobarbital. Am J Dis Child 1978;132:466-473. 3. Cohen SB, Burk RF: Acetaminophen overdoses at a county hospital: A year's experience. South Med J 1978;71:1359-1363.Crossref 4. Levy G, Khanna NN, Soda DM, et al: Pharmacokinetics of acetaminophen in the human neonate: Formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion. Pediatrics 1975;55:818-825. 5. Windorfer A, Vogel C: Prospective clinical study on the bioavailability of therapeutic doses of acetaminophen in children, abstracted. Klin Paediatr 1976;188:430-434. 6. Miller RP, Roberts RJ, Fischer LJ: Acetaminophen elimination kinetics in neonates, children, and adults. Clin Pharmacol Ther 1976;19:284-294. 7. Alam SN, Roberts RJ, Fischer LJ: Age-related differences in salicylamide and acetaminophen conjugation in man. J Pediatr 1977;90:130-135.Crossref 8. Loughnan PM, Greenwald A, Purton WW, et al: Pharmacokinetic observations of phenytoin disposition in the newborn and young infant. Arch Dis Child 1977;52:302-309.Crossref 9. Beaudry PH, Brickman HF, Wise MB, et al: Liver enzyme disturbances during isoniazid chemoprophylaxis in children. Am Rev Respir Dis 1974;110:581-584. 10. Nogen AG, Bremmer JE: Fatal acetaminophen overdosage in a young child. J Pediatr 1978;92:832-833.Crossref 11. Rumack BH, Matthew H: Acetaminophen poisoning and toxicity. Pediatrics 1975;55:871-876. 12. Meredith TJ, Newman B, Goulding R: Paracetamol poisoning in children. Br Med J 1978;2:478-479.Crossref 13. Rumack BH, Peterson RG: Acetaminophen overdose: Incidence, diagnosis, and management in 416 patients. Pediatrics 1978;62( (suppl 2) ):898-903.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 23, 1981

There are no references for this article.