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Antiemetic Effect of Tetrahydrocannabinol: Compared With Placebo and Prochlorperazine in Chemotherapy-Associated Nausea and Emesis

Antiemetic Effect of Tetrahydrocannabinol: Compared With Placebo and Prochlorperazine in... Abstract • Fifty-five patients harboring a variety of neoplasms and previously found to have severe nausea or emesis from antitumor drugs were given antiemetic prophylaxis in a double-blind, randomized, crossover fashion. Tetrahydrocannabinol (THC), prochlorperazine, and placebo were compared. Nausea was absent in 40 of 55 patients receiving THC, eight of 55 patients receiving prochlorperazine, and five of 55 in the placebo group. The antiemetic effect of THC appeared to be more efficacious for cyclophosphamide, fluorouracil, and doxorubicin hydrochloride, and less so for mechlorethamine hydrochloride and the nitrosureas. Tetrahydrocannabinol appears to offer significant control of nausea in most patients and exceeding by far that provided by prochlorperazine. (Arch Intern Med 140:1431-1433, 1980) References 1. Calabres IF, Parks RE: Alkylating agents, antimetabolites, and other antiproliferative agents , in Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 5. New York, Macmillan Publishing Co Inc, 1975, pp 1348-1395. 2. Moertel CG, Reitemeier RJ: Controlled clinical studies of orally administered antiemetic drugs. Gastroenterology 57:262-268, 1969. 3. Sallan SE, Zinberg NE, Frei E III: Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy. N Engl J Med 293:795-797, 1975.Crossref 4. Weil AT, Zinberg NE, Nelson JM: Clinical and psychological effects of marihuana in man. Science 162:1234-1242, 1968.Crossref 5. Allen T: Tetrahydrocannabinol and chemotherapy. N Engl J Med 294:168, 1976.Crossref 6. Ham MT, de Jong Y: 'Anti-emetic' activity of tetrahydrocannabinol in rats and pigeons. N Engl J Med 298:798-799, 1978.Crossref 7. Therapeutic possibilities in cannabinoids, editorial. Lancet 1:667-669, 1975. 8. Johnson RR: Elementary Statistics . North Scituate, Mass, Duxbury Press, 1973, pp 379-384, 1973. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Antiemetic Effect of Tetrahydrocannabinol: Compared With Placebo and Prochlorperazine in Chemotherapy-Associated Nausea and Emesis

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1980.00330220019010
Publisher site
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Abstract

Abstract • Fifty-five patients harboring a variety of neoplasms and previously found to have severe nausea or emesis from antitumor drugs were given antiemetic prophylaxis in a double-blind, randomized, crossover fashion. Tetrahydrocannabinol (THC), prochlorperazine, and placebo were compared. Nausea was absent in 40 of 55 patients receiving THC, eight of 55 patients receiving prochlorperazine, and five of 55 in the placebo group. The antiemetic effect of THC appeared to be more efficacious for cyclophosphamide, fluorouracil, and doxorubicin hydrochloride, and less so for mechlorethamine hydrochloride and the nitrosureas. Tetrahydrocannabinol appears to offer significant control of nausea in most patients and exceeding by far that provided by prochlorperazine. (Arch Intern Med 140:1431-1433, 1980) References 1. Calabres IF, Parks RE: Alkylating agents, antimetabolites, and other antiproliferative agents , in Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 5. New York, Macmillan Publishing Co Inc, 1975, pp 1348-1395. 2. Moertel CG, Reitemeier RJ: Controlled clinical studies of orally administered antiemetic drugs. Gastroenterology 57:262-268, 1969. 3. Sallan SE, Zinberg NE, Frei E III: Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy. N Engl J Med 293:795-797, 1975.Crossref 4. Weil AT, Zinberg NE, Nelson JM: Clinical and psychological effects of marihuana in man. Science 162:1234-1242, 1968.Crossref 5. Allen T: Tetrahydrocannabinol and chemotherapy. N Engl J Med 294:168, 1976.Crossref 6. Ham MT, de Jong Y: 'Anti-emetic' activity of tetrahydrocannabinol in rats and pigeons. N Engl J Med 298:798-799, 1978.Crossref 7. Therapeutic possibilities in cannabinoids, editorial. Lancet 1:667-669, 1975. 8. Johnson RR: Elementary Statistics . North Scituate, Mass, Duxbury Press, 1973, pp 379-384, 1973.

Journal

Archives of Internal Medicine – American Medical Association

Published: Nov 1, 1980

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