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Acute Lymphoblastic Leukemia: Association With Vasopressin-Responsive Diabetes Insipidus

Acute Lymphoblastic Leukemia: Association With Vasopressin-Responsive Diabetes Insipidus Abstract • A rare case of acute lymphoblastic leukemia presenting with vasopressin-responsive diabetes insipidus (DI) is reported. The patient presented with polydypsia and polyuria of 9 L/day. Findings from special investigations of the CNS, including brain scan, computerized tomographic scan, EEG, and lumbar puncture were within normal limits. The patient's condition improved substantially after receiving vasopressin injections and later chlorpropamide. The incidence and underlying mechanism of this rare complication of acute leukemia are reviewed, and the response of DI to chlorpropamide is discussed briefly. In this patient it is presumed that the DI was caused by leukemic infiltration of the supraopticohypophyseal tract, posterior pituitary, or hypothalamus. (Arch Intern Med 140:1236, 1980) References 1. Pochedly C: Neurologic manifestations in acute leukemia: II. Involvement of cranial nerves and hypothalamus. NY State J Med 75:715-721, 1975. 2. Miller VI, Campbell WG: Diabetes insipidus as a complication of leukemia: A case report with a literature review. Cancer 28:666-673, 1971.Crossref 3. Betkerur W, Shende A, Lanzkowsky P: Acute myeloblastic leukemia presenting with diabetes insipidus. Am J Med Sci 273:325-327, 1977.Crossref 4. Cumming WJK, Spiers ASD: Diabetes insipidus and marked elevation of foetal haemoglobin in a case of acute leukemia. Postgrad Med J 50:468-470, 1974.Crossref 5. Masse SR, Wolk RW, Conklin RH: Peripituitary gland involvement in acute leukemia in adults. Arch Pathol 96:141-142, 1973. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Acute Lymphoblastic Leukemia: Association With Vasopressin-Responsive Diabetes Insipidus

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Acute Lymphoblastic Leukemia: Association With Vasopressin-Responsive Diabetes Insipidus

Abstract

Abstract • A rare case of acute lymphoblastic leukemia presenting with vasopressin-responsive diabetes insipidus (DI) is reported. The patient presented with polydypsia and polyuria of 9 L/day. Findings from special investigations of the CNS, including brain scan, computerized tomographic scan, EEG, and lumbar puncture were within normal limits. The patient's condition improved substantially after receiving vasopressin injections and later chlorpropamide. The incidence and...
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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1980.00330200112030
Publisher site
See Article on Publisher Site

Abstract

Abstract • A rare case of acute lymphoblastic leukemia presenting with vasopressin-responsive diabetes insipidus (DI) is reported. The patient presented with polydypsia and polyuria of 9 L/day. Findings from special investigations of the CNS, including brain scan, computerized tomographic scan, EEG, and lumbar puncture were within normal limits. The patient's condition improved substantially after receiving vasopressin injections and later chlorpropamide. The incidence and underlying mechanism of this rare complication of acute leukemia are reviewed, and the response of DI to chlorpropamide is discussed briefly. In this patient it is presumed that the DI was caused by leukemic infiltration of the supraopticohypophyseal tract, posterior pituitary, or hypothalamus. (Arch Intern Med 140:1236, 1980) References 1. Pochedly C: Neurologic manifestations in acute leukemia: II. Involvement of cranial nerves and hypothalamus. NY State J Med 75:715-721, 1975. 2. Miller VI, Campbell WG: Diabetes insipidus as a complication of leukemia: A case report with a literature review. Cancer 28:666-673, 1971.Crossref 3. Betkerur W, Shende A, Lanzkowsky P: Acute myeloblastic leukemia presenting with diabetes insipidus. Am J Med Sci 273:325-327, 1977.Crossref 4. Cumming WJK, Spiers ASD: Diabetes insipidus and marked elevation of foetal haemoglobin in a case of acute leukemia. Postgrad Med J 50:468-470, 1974.Crossref 5. Masse SR, Wolk RW, Conklin RH: Peripituitary gland involvement in acute leukemia in adults. Arch Pathol 96:141-142, 1973.

Journal

Archives of Internal Medicine – American Medical Association

Published: Sep 1, 1980

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