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Anemia of Primary Hyperparathyroidism

Anemia of Primary Hyperparathyroidism Abstract To the Editor.— We read with interest the article by Boxer et al and the editorial comment by Mallete that appeared in the May issue of the Archives (137:588-590 and 572-573, respectively, 1977). Dr Mallette raised the question of whether secondary hyperparathyroidism contributes to the anemia of chronic uremia. In our experience, subtotal parathyroidectomy or suppression of parathyroid activity with the administration of 1α-hydroxy-D3 may result in improvement of the anemia in some, though not all, patients receiving hemodialysis.1In an independent study, Zingraff et al made similar observations.2 In addition, they showed that parathyroidectomy or the administration of 1α-hydroxy-D3 leads to regression of the marrow fibrosis of uremic osteitis fibrosa and thus improves the bone marrow function of these patients.These preliminary findings suggest that the suppression of the hyperfunctioning parathyroid gland in chronic uremia may be beneficial for the treatment of the anemia of References 1. Better OS, Shasha SM, Winaver J, et al: Improvement in the anemia of hemodialysed patients following parathyroidectomy , abstracted. From the Proceedings of the Ninth Annual Meeting of the American Society of Nephrologists, Washington, DC, 1977 . 2. Zingraff J, Drueke T, Brodier P, et al: Subtotal parathyroidectomy in chronic dialysis patients . From the Proceedings of the Second International Workshop on Phosphate, Heidelberg, West Germany, 1976 . 3. Zingraff J, Bordier T, Drueke N: Short-term effect of 1-hydroxy versus 25-hydroxy vitamin D3 compounds in renal bone disease , abstracted. Kid Int 9:524, 1976. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Anemia of Primary Hyperparathyroidism

Better, Ori S.; Shasha, S.
Archives of Internal Medicine , Volume 137 (12) – Dec 1, 1977
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Anemia of Primary Hyperparathyroidism

Abstract

Abstract To the Editor.— We read with interest the article by Boxer et al and the editorial comment by Mallete that appeared in the May issue of the Archives (137:588-590 and 572-573, respectively, 1977). Dr Mallette raised the question of whether secondary hyperparathyroidism contributes to the anemia of chronic uremia. In our experience, subtotal parathyroidectomy or suppression of parathyroid activity with the administration of 1α-hydroxy-D3 may result in improvement of the...
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1977.03630240074034
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— We read with interest the article by Boxer et al and the editorial comment by Mallete that appeared in the May issue of the Archives (137:588-590 and 572-573, respectively, 1977). Dr Mallette raised the question of whether secondary hyperparathyroidism contributes to the anemia of chronic uremia. In our experience, subtotal parathyroidectomy or suppression of parathyroid activity with the administration of 1α-hydroxy-D3 may result in improvement of the anemia in some, though not all, patients receiving hemodialysis.1In an independent study, Zingraff et al made similar observations.2 In addition, they showed that parathyroidectomy or the administration of 1α-hydroxy-D3 leads to regression of the marrow fibrosis of uremic osteitis fibrosa and thus improves the bone marrow function of these patients.These preliminary findings suggest that the suppression of the hyperfunctioning parathyroid gland in chronic uremia may be beneficial for the treatment of the anemia of References 1. Better OS, Shasha SM, Winaver J, et al: Improvement in the anemia of hemodialysed patients following parathyroidectomy , abstracted. From the Proceedings of the Ninth Annual Meeting of the American Society of Nephrologists, Washington, DC, 1977 . 2. Zingraff J, Drueke T, Brodier P, et al: Subtotal parathyroidectomy in chronic dialysis patients . From the Proceedings of the Second International Workshop on Phosphate, Heidelberg, West Germany, 1976 . 3. Zingraff J, Bordier T, Drueke N: Short-term effect of 1-hydroxy versus 25-hydroxy vitamin D3 compounds in renal bone disease , abstracted. Kid Int 9:524, 1976.

Journal

Archives of Internal Medicine – American Medical Association

Published: Dec 1, 1977

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