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RBC Transfusions in Paroxysmal Nocturnal Hemoglobinuria

RBC Transfusions in Paroxysmal Nocturnal Hemoglobinuria Abstract Frozen-thawed, deglycerolized RBCs can be substituted for saline-washed RBCs for transfusion of patients with paroxysmal nocturnal hemoglobinuria (PNH). The effect of transfusion is to decrease bone marrow production of RBCs, which results in a decreased percentage of complement-sensitive erythrocytes. In the presence of small numbers of complement-sensitive erythrocytes, major vascular surgery can be performed without hemolytic problems. This study suggests that the percentage of complement-sensitive RBCs, as well as the complement sensitivity of these cells, influence the severity of hemolysis in persons with PNH. (Arch Intern Med 137:536-538, 1977) References 1. Rosse WF, Dacie JV: Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells: I. The sensitivity of PNH red cells to lysis by complement and specific antibody . J Clin Invest 45:736-748, 1966.Crossref 2. Yachnin S: The hemolysis of red cells from patients with paroxysmal nocturnal hemoglobinuria by partially purified subcomponents of the third complement component . J Clin Invest 44:1534-1546, 1965.Crossref 3. Götze O, Müller-Eberhard HJ: Lysis of erythrocytes by complement in the absence of antibody . J Exp Med 132:878-915, 1970.Crossref 4. Rosse WF: Paroxysmal nocturnal hemoglobinuria , in Williams WJ, Beutler E, Erslev AJ, et al (eds): Hematology . New York, McGraw-Hill Book Co Inc, 1972, pp 460-474. 5. Hamburger LP, Bernstein A: Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria . Am J Med Sci 192:301-316, 1936.Crossref 6. Dacie JV, Firth D: Blood transfusion in nocturnal hemoglobinuria . Br Med J 1:626-628, 1943.Crossref 7. Sirchia G, Ferrone S, Mercuriali F: Leukocyte antigen-antibody reaction and lysis of paroxysmal nocturnal hemoglobinuria erythrocytes . Blood 36:334-336, 1970. 8. Crosby WH, Stefanni M: Pathogenesis of the plasma transfusion reaction with special reference to the blood coagulation system . J Lab Clin Med 40:374-386, 1952. 9. Dacie JV: Transfusion of saline-washed red cells in nocturnal hemoglobinuria . Clin Sci 7:65-75, 1949. 10. Hartmann RC, Kolhouse F: Viewpoints on the management of paroxysmal nocturnal hemoglobinuria (PNH) . Ser Haematol 5:42-60, 1972. 11. Dacie JV: Paroxysmal nocturnal haemoglobinuria in The Haemolytic Anaemias . New York, Grune & Stratton Inc, 1967, pp 1128-1260. 12. Beal RW, Kronenberg H, Firkin BG: The syndrome of paroxysmal nocturnal hemoglobinuria . Am J Med 37:899-914, 1964.Crossref 13. Hartmann RC, Jenkins DE Jr, McKee CL, et al: Paroxysmal nocturnal hemoglobinuria: Clinical and laboratory studies relating to iron metabolism and therapy with androgen and iron . Medicine 45:331-363, 1966.Crossref 14. Crosby WH, Furth FW: A modification of the benzidine method for measurement of hemoglobulin in plasma and urine . Blood 11:380-383, 1956. 15. Gockerman JP, Durocher JR, Conrad ME: The abnormal surface characteristics of the red blood cell membrane in congenital dyserythropietic anaemia type II (Hempas) . Br J Haematol 30:377-388, 1975.Crossref 16. Coburn RF, Williams WJ, Kahn SB: Endogenous carbon monoxide production in patients with hemolytic anemia . J Clin Invest 45:460-468, 1966.Crossref 17. Bensinger TA, Maisels MJ, Mahmood J, et al: Effect of intravenous urea in invert sugar on heme catabolism in sickle-cell anemia . N Engl J Med 285:995-997, 1971.Crossref 18. Logue GL, Rosse WF, Adams JP: Mechanisms of immune lysis of red blood cells in vitro: I. Paroxysmal nocturnal hemoglobinuria . J Clin Invest 52:1129-1137, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

RBC Transfusions in Paroxysmal Nocturnal Hemoglobinuria

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1977.03630160092019
Publisher site
See Article on Publisher Site

Abstract

Abstract Frozen-thawed, deglycerolized RBCs can be substituted for saline-washed RBCs for transfusion of patients with paroxysmal nocturnal hemoglobinuria (PNH). The effect of transfusion is to decrease bone marrow production of RBCs, which results in a decreased percentage of complement-sensitive erythrocytes. In the presence of small numbers of complement-sensitive erythrocytes, major vascular surgery can be performed without hemolytic problems. This study suggests that the percentage of complement-sensitive RBCs, as well as the complement sensitivity of these cells, influence the severity of hemolysis in persons with PNH. (Arch Intern Med 137:536-538, 1977) References 1. Rosse WF, Dacie JV: Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells: I. The sensitivity of PNH red cells to lysis by complement and specific antibody . J Clin Invest 45:736-748, 1966.Crossref 2. Yachnin S: The hemolysis of red cells from patients with paroxysmal nocturnal hemoglobinuria by partially purified subcomponents of the third complement component . J Clin Invest 44:1534-1546, 1965.Crossref 3. Götze O, Müller-Eberhard HJ: Lysis of erythrocytes by complement in the absence of antibody . J Exp Med 132:878-915, 1970.Crossref 4. Rosse WF: Paroxysmal nocturnal hemoglobinuria , in Williams WJ, Beutler E, Erslev AJ, et al (eds): Hematology . New York, McGraw-Hill Book Co Inc, 1972, pp 460-474. 5. Hamburger LP, Bernstein A: Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria . Am J Med Sci 192:301-316, 1936.Crossref 6. Dacie JV, Firth D: Blood transfusion in nocturnal hemoglobinuria . Br Med J 1:626-628, 1943.Crossref 7. Sirchia G, Ferrone S, Mercuriali F: Leukocyte antigen-antibody reaction and lysis of paroxysmal nocturnal hemoglobinuria erythrocytes . Blood 36:334-336, 1970. 8. Crosby WH, Stefanni M: Pathogenesis of the plasma transfusion reaction with special reference to the blood coagulation system . J Lab Clin Med 40:374-386, 1952. 9. Dacie JV: Transfusion of saline-washed red cells in nocturnal hemoglobinuria . Clin Sci 7:65-75, 1949. 10. Hartmann RC, Kolhouse F: Viewpoints on the management of paroxysmal nocturnal hemoglobinuria (PNH) . Ser Haematol 5:42-60, 1972. 11. Dacie JV: Paroxysmal nocturnal haemoglobinuria in The Haemolytic Anaemias . New York, Grune & Stratton Inc, 1967, pp 1128-1260. 12. Beal RW, Kronenberg H, Firkin BG: The syndrome of paroxysmal nocturnal hemoglobinuria . Am J Med 37:899-914, 1964.Crossref 13. Hartmann RC, Jenkins DE Jr, McKee CL, et al: Paroxysmal nocturnal hemoglobinuria: Clinical and laboratory studies relating to iron metabolism and therapy with androgen and iron . Medicine 45:331-363, 1966.Crossref 14. Crosby WH, Furth FW: A modification of the benzidine method for measurement of hemoglobulin in plasma and urine . Blood 11:380-383, 1956. 15. Gockerman JP, Durocher JR, Conrad ME: The abnormal surface characteristics of the red blood cell membrane in congenital dyserythropietic anaemia type II (Hempas) . Br J Haematol 30:377-388, 1975.Crossref 16. Coburn RF, Williams WJ, Kahn SB: Endogenous carbon monoxide production in patients with hemolytic anemia . J Clin Invest 45:460-468, 1966.Crossref 17. Bensinger TA, Maisels MJ, Mahmood J, et al: Effect of intravenous urea in invert sugar on heme catabolism in sickle-cell anemia . N Engl J Med 285:995-997, 1971.Crossref 18. Logue GL, Rosse WF, Adams JP: Mechanisms of immune lysis of red blood cells in vitro: I. Paroxysmal nocturnal hemoglobinuria . J Clin Invest 52:1129-1137, 1973.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Apr 1, 1977

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