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Vitamin D Metabolism in Man: Effect of Corticosteroids

Vitamin D Metabolism in Man: Effect of Corticosteroids Abstract This study evaluated the effects of acute intravenous calcium supplementation on vitamin D metabolism in nine patients maintained on long-term prednisone therapy for chronic obstructive lung disease. Vitamin D turnover studies, employing 1,2-3H,414C vitamin D3 and coincident measurement of serum 25-hydroxycholecalciferol (25-OHCC) concentrations demonstrated that intravenous calcium administration decreased the mean 25-OHCC concentration (P <.05) and half-time (P <.05) in the prednisone-treated patients when compared with the mean 25-OHCC concentration and half-time found in these patients prior to calcium infusion. However, there was no significant difference in the amounts of 24,25-dihydroxycholecalciferol (24,25-(OH)2CC) or 1,25-dihydroxycholecalciferol (1,25-(OH)2CC) appearing after calcium infusion. The results of the study showed that the intravenous administration of calcium to corticosteroidtreated patients accelerated the disappearance of 25-OHCC from the plasma of these patients without parallel increases in the production of 1,25-(OH)2CC or 24,25-(OH)2CC. (Arch Intern Med 136:1241-1248, 1976) References 1. Harrison HE, Harrison HC: Transfer of Ca" across intestinal wall in vitro in relation to action of vitamin D and cortisol . Am J Physiol 199:265-271, 1960. 2. Sallis JC, Holdsworth ES: Calcium metabolism in relation to vitamin D3 and adrenal function in the chick . Am J Physiol 203:506-512, 1962. 3. Verner JV, Engel FL, McPherson HT: Vitamin D intoxication: Report of two cases treated with cortisone . Ann Intern Med 48:765-773, 1958.Crossref 4. Kimberg DV, Baerg RD, Gershon E, et al: Effect of cortisone treatment on the active transport of calcium by the small intestine . J Clin Invest 50:1309-1321, 1971.Crossref 5. Krawitt EL: The role of intestinal transport proteins in cortisone-mediated suppression of Ca2+ absorption . Biochim Biophys Acta 274:179-188, 1972.Crossref 6. Avioli LV, Birge SJ, Lee SW: Effects of prednisone on vitamin D metabolism in man . J Clin Endocrinol 28:1341-1346, 1968.Crossref 7. Lukert BP, Stanbury SW, Mawer EB: Vitamin D and intestinal transport of calcium: Effects of prednisolone . Endocrinology 93:718-722, 1973.Crossref 8. Raisz LG, Trummel CL, Halick MF, et al: 1,25-dihydroxycholecalciferol: A potent stimulator of bone resorption in tissue . Science 175:768-769, 1972.Crossref 9. Bikle DD, Rasmussen H: The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules . J Clin Invest 55:292-298, 1975.Crossref 10. Bikle DD, Murphy EW, Rasmussen H: The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria . J Clin Invest 55:299-304, 1975.Crossref 11. Mawer EB, Backhouse J: An improved system for the separation of isotopically labeled vitamin D, on silicic acid columns . Biochem J 112:255-256, 1969. 12. Taylor CM, Mawer EB, Reeves A: The metabolism of cholecalciferol in 1-hydroxyethyl-l,l,diphosphonate treated chicks . Biochem Soc Trans 1:596-599, 1973. 13. Kodicek E, Lawson DEM, Wilson PW: Biological activity of a polar metabolite of vitamin D3 . Nature 228:763-764, 1970.Crossref 14. Belsey R, DeLuca HF, Potts JT: Competitive binding assay for vitamin D and 25-OH vitamin D . Rapid Comm 33:554-557, 1971. 15. Belsey R, DeLuca HF, Po:ts JT: A rapid assay for 25-OH-vitamin D3 without preparative chromatography . J Clin Endocrinol Metab 38:1046-1051, 1974.Crossref 16. Williams GA, Peterson WC, Bowser EN, et al: Interrelationship of parathyroid and adrenocortical function in calcium homeostasis in the rat . Endocrinology 95:707-712, 1974.Crossref 17. Storey E: The influence of adrenal cortical hormones on bone formation and resorption . Clin Orthop 30:197-216, 1963.Crossref 18. Smith JE, Goodman DS: The turnover and transport of vitamin D and of a polar metabolite with the properties of 25-hydroxycholecalciferol in human plasma . J Clin Invest 50:2159-2167, 1971.Crossref 19. Avioli LV, Lee SW, McDonald JE, et al: Metabolism of vitamin D3-3H in human subjects: Distribution in blood, feces, and urine . J Clin Invest 46:983-992, 1967.Crossref 20. Mawer EB, Lumb GA, Schaefer K, et al: The metabolism of isotopically labeled vitamin D, in man: The influence of the state of vitamin D nutrition . Clin Sci 40:39-53, 1971. 21. Baynard F, Bee P, Louvet JP, et al: 25- Hydroxycholecalciferol dynamics in human plasma , in Proceedings of the Fourth International Congress on Endocrinology , Excerpta Medica International Congress series 256, Washington, DC, 1972. 22. Adams JS, Lukert BP: Intestinal calcium and sodium fluxes in corticosteroid-treated rats . Fed Proc 34:917, 1975. 23. Craig W, Lukert BP: The effect of calcium infusion on biliary excretion of vitamin D. Clin Res 23:648A, 1974. 24. Mawer EB, Backhouse J, Hill LF, et al: Vitamin D metabolism and parathyroid function in man . Clin Sci Mol Med 48:349-365, 1975. 25. Caniggia A, Gennari C: Effect of 25-hydroxycholecalciferol (25-HCC) on intestinal absorption of "Ca in four cases of iatrogenic Cushing's syndrome . Helv Med Acta 37:221-225, 1974. 26. Gallagher JC, Aaron J, Horsman R, et al: Corticosteroid osteoporosis . J Clin Endocrinol Metab 2:355-368, 1973.Crossref 27. Baylink D, Stauffer M, Wergedal J, et al: Formation, mineralization, and resorption of bone in vitamin D-deficient rats . J Clin Invest 49:112, 1970. 28. Rasmussen H, Bordier P, Kurokawa K, et al: Hormonal control of skeletal and mineral homeostasis . Am J Med 56:751-758, 1974.Crossref 29. Ajdukiewicz AB, Agnew JE, Beepers PD, et al: The relief of bone pain in primary biliary cirrhosis with calcium infusions . Gut 15:788-793, 1974.Crossref 30. Pak CYC, Zisman E, Evens B, et al: The treatment of osteoporosis with calcium infusions . Am J Med 47:7-16, 1969.Crossref 31. Fucik RF, Kubreja SC, Hargis GK, et al: Effect of glucocorticoids on function of the parathyroid glands in man . J Clin Endocrinol Metab 40:152-155, 1974.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Vitamin D Metabolism in Man: Effect of Corticosteroids

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References (38)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1976.03630110017008
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Abstract

Abstract This study evaluated the effects of acute intravenous calcium supplementation on vitamin D metabolism in nine patients maintained on long-term prednisone therapy for chronic obstructive lung disease. Vitamin D turnover studies, employing 1,2-3H,414C vitamin D3 and coincident measurement of serum 25-hydroxycholecalciferol (25-OHCC) concentrations demonstrated that intravenous calcium administration decreased the mean 25-OHCC concentration (P <.05) and half-time (P <.05) in the prednisone-treated patients when compared with the mean 25-OHCC concentration and half-time found in these patients prior to calcium infusion. However, there was no significant difference in the amounts of 24,25-dihydroxycholecalciferol (24,25-(OH)2CC) or 1,25-dihydroxycholecalciferol (1,25-(OH)2CC) appearing after calcium infusion. The results of the study showed that the intravenous administration of calcium to corticosteroidtreated patients accelerated the disappearance of 25-OHCC from the plasma of these patients without parallel increases in the production of 1,25-(OH)2CC or 24,25-(OH)2CC. (Arch Intern Med 136:1241-1248, 1976) References 1. Harrison HE, Harrison HC: Transfer of Ca" across intestinal wall in vitro in relation to action of vitamin D and cortisol . Am J Physiol 199:265-271, 1960. 2. Sallis JC, Holdsworth ES: Calcium metabolism in relation to vitamin D3 and adrenal function in the chick . Am J Physiol 203:506-512, 1962. 3. Verner JV, Engel FL, McPherson HT: Vitamin D intoxication: Report of two cases treated with cortisone . Ann Intern Med 48:765-773, 1958.Crossref 4. Kimberg DV, Baerg RD, Gershon E, et al: Effect of cortisone treatment on the active transport of calcium by the small intestine . J Clin Invest 50:1309-1321, 1971.Crossref 5. Krawitt EL: The role of intestinal transport proteins in cortisone-mediated suppression of Ca2+ absorption . Biochim Biophys Acta 274:179-188, 1972.Crossref 6. Avioli LV, Birge SJ, Lee SW: Effects of prednisone on vitamin D metabolism in man . J Clin Endocrinol 28:1341-1346, 1968.Crossref 7. Lukert BP, Stanbury SW, Mawer EB: Vitamin D and intestinal transport of calcium: Effects of prednisolone . Endocrinology 93:718-722, 1973.Crossref 8. Raisz LG, Trummel CL, Halick MF, et al: 1,25-dihydroxycholecalciferol: A potent stimulator of bone resorption in tissue . Science 175:768-769, 1972.Crossref 9. Bikle DD, Rasmussen H: The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules . J Clin Invest 55:292-298, 1975.Crossref 10. Bikle DD, Murphy EW, Rasmussen H: The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria . J Clin Invest 55:299-304, 1975.Crossref 11. Mawer EB, Backhouse J: An improved system for the separation of isotopically labeled vitamin D, on silicic acid columns . Biochem J 112:255-256, 1969. 12. Taylor CM, Mawer EB, Reeves A: The metabolism of cholecalciferol in 1-hydroxyethyl-l,l,diphosphonate treated chicks . Biochem Soc Trans 1:596-599, 1973. 13. Kodicek E, Lawson DEM, Wilson PW: Biological activity of a polar metabolite of vitamin D3 . Nature 228:763-764, 1970.Crossref 14. Belsey R, DeLuca HF, Potts JT: Competitive binding assay for vitamin D and 25-OH vitamin D . Rapid Comm 33:554-557, 1971. 15. Belsey R, DeLuca HF, Po:ts JT: A rapid assay for 25-OH-vitamin D3 without preparative chromatography . J Clin Endocrinol Metab 38:1046-1051, 1974.Crossref 16. Williams GA, Peterson WC, Bowser EN, et al: Interrelationship of parathyroid and adrenocortical function in calcium homeostasis in the rat . Endocrinology 95:707-712, 1974.Crossref 17. Storey E: The influence of adrenal cortical hormones on bone formation and resorption . Clin Orthop 30:197-216, 1963.Crossref 18. Smith JE, Goodman DS: The turnover and transport of vitamin D and of a polar metabolite with the properties of 25-hydroxycholecalciferol in human plasma . J Clin Invest 50:2159-2167, 1971.Crossref 19. Avioli LV, Lee SW, McDonald JE, et al: Metabolism of vitamin D3-3H in human subjects: Distribution in blood, feces, and urine . J Clin Invest 46:983-992, 1967.Crossref 20. Mawer EB, Lumb GA, Schaefer K, et al: The metabolism of isotopically labeled vitamin D, in man: The influence of the state of vitamin D nutrition . Clin Sci 40:39-53, 1971. 21. Baynard F, Bee P, Louvet JP, et al: 25- Hydroxycholecalciferol dynamics in human plasma , in Proceedings of the Fourth International Congress on Endocrinology , Excerpta Medica International Congress series 256, Washington, DC, 1972. 22. Adams JS, Lukert BP: Intestinal calcium and sodium fluxes in corticosteroid-treated rats . Fed Proc 34:917, 1975. 23. Craig W, Lukert BP: The effect of calcium infusion on biliary excretion of vitamin D. Clin Res 23:648A, 1974. 24. Mawer EB, Backhouse J, Hill LF, et al: Vitamin D metabolism and parathyroid function in man . Clin Sci Mol Med 48:349-365, 1975. 25. Caniggia A, Gennari C: Effect of 25-hydroxycholecalciferol (25-HCC) on intestinal absorption of "Ca in four cases of iatrogenic Cushing's syndrome . Helv Med Acta 37:221-225, 1974. 26. Gallagher JC, Aaron J, Horsman R, et al: Corticosteroid osteoporosis . J Clin Endocrinol Metab 2:355-368, 1973.Crossref 27. Baylink D, Stauffer M, Wergedal J, et al: Formation, mineralization, and resorption of bone in vitamin D-deficient rats . J Clin Invest 49:112, 1970. 28. Rasmussen H, Bordier P, Kurokawa K, et al: Hormonal control of skeletal and mineral homeostasis . Am J Med 56:751-758, 1974.Crossref 29. Ajdukiewicz AB, Agnew JE, Beepers PD, et al: The relief of bone pain in primary biliary cirrhosis with calcium infusions . Gut 15:788-793, 1974.Crossref 30. Pak CYC, Zisman E, Evens B, et al: The treatment of osteoporosis with calcium infusions . Am J Med 47:7-16, 1969.Crossref 31. Fucik RF, Kubreja SC, Hargis GK, et al: Effect of glucocorticoids on function of the parathyroid glands in man . J Clin Endocrinol Metab 40:152-155, 1974.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Nov 1, 1976

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