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Urinary Bladder Complications With Cyclophosphamide Therapy

Urinary Bladder Complications With Cyclophosphamide Therapy Abstract The use of cytotoxic drugs in rheumatic diseases is attended by many potential side-effects, including infection, bone marrow depression, gastrointestinal toxic reactions, infertility, teratogenesis, and neoplasia.1 In addition, individual drugs have rather specific side-effects. The urinary bladder complications that have been reported with the use of cyclophosphamide include acute hemorrhagic cystitis, chronic cystitis, urine cytologic abnormalities, mucosal telangiectasia, interstitial fibrosis, and transitional cell carcinoma.2 We report the occurrence of severe and prolonged hemorrhagic cystitis, bladder calculi, and eosinophilic cystitis in a patient with systemic lupus erythematosus (SLE) who was treated with cyclophosphamide. PATIENT SUMMARY An 18-year-old man was admitted to a neighboring hospital with acute psychosis, epilepsy, and pericarditis in November 1968. The result of an antinuclear factor (ANF) test was reported to be positive. A diagnosis of SLE with cerebral vasculitis was made, and the patient was treated with corticotropin and cyclophosphamide, intravenously. During the next ten References 1. Decker JL, Bertino JR, Hurd ER, et al: Cytotoxic drugs in rheumatic diseases . Arthritis Rheum 16:79-96, 1973.Crossref 2. Aptekar RG, Atkinson JP, Decker JL, et al: Bladder toxicity with chronic oral cyclophosphamide therapy in nonmalignant diseases . Arthritis Rheum 16:461-467, 1973.Crossref 3. Anderson EE, Cobb OE, Glenn JF: Cyclophosphamide hemorrhagic cystitis . J Urol 97:857-858, 1967. 4. Riggenbach R, Barrett O Jr, Shown T: Hemorrhagic cystitis due to cyclophosphamide: Report of two cases . South Med J 61:139-141, 1968.Crossref 5. Hutter AM Jr, Bauman AW, Frank IN: Cyclophosphamide and severe hemorrhagic cystitis . NY State J Med 69:305-309, 1969. 6. Berkson BM, Lome LG, Shapiro I: Severe cystitis induced by cyclophosphamide: Role of surgical management . JAMA 225:605-606, 1973.Crossref 7. Brown EW: Eosinophilic granuloma of the bladder . J Urol 83:665-667, 1960. 8. Palubinskas AJ: Eosinophilic cystitis: Case report of eosinophilic infiltration of the urinary bladder . Radiology 75:589-591, 1960.Crossref 9. Farber S, Vawter GF: Clinical pathological conference . J Pediatr 62:941-945, 1963.Crossref 10. Wenzl JF, Greene LF, Harris LE: Eosinophilic cystitis . J Pediatr 64:746-749, 1964.Crossref 11. Champion RH, Ackles RC: Eosinophilic cystitis . J Urol 96:729-732, 1966. 12. Perlmutter AD, Edlow JB, Kevy SV: Toxocara antibodies in eosinophilic cystitis . J Pedi atr 73:340-344, 1968.Crossref 13. Fossgreen J: Eosinophile granulomatosis: Ein ungewöhnlicher Fall mit Veranderungen im Darm, den Lymphknoten des Mesenteriums, den Ovarien, im Uterus, der Harnblase und im Herzen . Acta Pathol Microbiol Scand 56:143-154, 1962.Crossref 14. Gregg JA, Utz DC: Eosinophilic cystitis associated with eosinophilic gastroenteritis . Mayo Clin Proc 49:185-187, 1974. 15. Steinberg AD, Kaltreider HB, Staples PJ, et al: Cyclophosphamide in lupus nephritis: A controlled trial . Ann Intern Med 75:165-171, 1971.Crossref 16. Cameron JS, Boulton-Jones M, Robinson R, et al: Treatment of lupus nephritis with cyclophosphamide . Lancet 2:846-849, 1970. 17. Snaith ML, Holt JM, Oliver DO, et al: Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil . Br Med J 2:197-201, 1973.Crossref 18. Drinkard JP, Stanley TM, Dornfield L, et al: Azathioprine and prednisone in the treatment of adults with lupus nephritis: Clinical, histological, and immunological changes with therapy . Medicine 49:411-432, 1970.Crossref 19. Donadio JV, Holley KE, Wagoner RL, et al: Treatment of lupus nephritis with prednisone and combined prednisone and azathioprine . Ann Intern Med 77:829-835, 1972.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Urinary Bladder Complications With Cyclophosphamide Therapy

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References (22)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1976.03630050090015
Publisher site
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Abstract

Abstract The use of cytotoxic drugs in rheumatic diseases is attended by many potential side-effects, including infection, bone marrow depression, gastrointestinal toxic reactions, infertility, teratogenesis, and neoplasia.1 In addition, individual drugs have rather specific side-effects. The urinary bladder complications that have been reported with the use of cyclophosphamide include acute hemorrhagic cystitis, chronic cystitis, urine cytologic abnormalities, mucosal telangiectasia, interstitial fibrosis, and transitional cell carcinoma.2 We report the occurrence of severe and prolonged hemorrhagic cystitis, bladder calculi, and eosinophilic cystitis in a patient with systemic lupus erythematosus (SLE) who was treated with cyclophosphamide. PATIENT SUMMARY An 18-year-old man was admitted to a neighboring hospital with acute psychosis, epilepsy, and pericarditis in November 1968. The result of an antinuclear factor (ANF) test was reported to be positive. A diagnosis of SLE with cerebral vasculitis was made, and the patient was treated with corticotropin and cyclophosphamide, intravenously. During the next ten References 1. Decker JL, Bertino JR, Hurd ER, et al: Cytotoxic drugs in rheumatic diseases . Arthritis Rheum 16:79-96, 1973.Crossref 2. Aptekar RG, Atkinson JP, Decker JL, et al: Bladder toxicity with chronic oral cyclophosphamide therapy in nonmalignant diseases . Arthritis Rheum 16:461-467, 1973.Crossref 3. Anderson EE, Cobb OE, Glenn JF: Cyclophosphamide hemorrhagic cystitis . J Urol 97:857-858, 1967. 4. Riggenbach R, Barrett O Jr, Shown T: Hemorrhagic cystitis due to cyclophosphamide: Report of two cases . South Med J 61:139-141, 1968.Crossref 5. Hutter AM Jr, Bauman AW, Frank IN: Cyclophosphamide and severe hemorrhagic cystitis . NY State J Med 69:305-309, 1969. 6. Berkson BM, Lome LG, Shapiro I: Severe cystitis induced by cyclophosphamide: Role of surgical management . JAMA 225:605-606, 1973.Crossref 7. Brown EW: Eosinophilic granuloma of the bladder . J Urol 83:665-667, 1960. 8. Palubinskas AJ: Eosinophilic cystitis: Case report of eosinophilic infiltration of the urinary bladder . Radiology 75:589-591, 1960.Crossref 9. Farber S, Vawter GF: Clinical pathological conference . J Pediatr 62:941-945, 1963.Crossref 10. Wenzl JF, Greene LF, Harris LE: Eosinophilic cystitis . J Pediatr 64:746-749, 1964.Crossref 11. Champion RH, Ackles RC: Eosinophilic cystitis . J Urol 96:729-732, 1966. 12. Perlmutter AD, Edlow JB, Kevy SV: Toxocara antibodies in eosinophilic cystitis . J Pedi atr 73:340-344, 1968.Crossref 13. Fossgreen J: Eosinophile granulomatosis: Ein ungewöhnlicher Fall mit Veranderungen im Darm, den Lymphknoten des Mesenteriums, den Ovarien, im Uterus, der Harnblase und im Herzen . Acta Pathol Microbiol Scand 56:143-154, 1962.Crossref 14. Gregg JA, Utz DC: Eosinophilic cystitis associated with eosinophilic gastroenteritis . Mayo Clin Proc 49:185-187, 1974. 15. Steinberg AD, Kaltreider HB, Staples PJ, et al: Cyclophosphamide in lupus nephritis: A controlled trial . Ann Intern Med 75:165-171, 1971.Crossref 16. Cameron JS, Boulton-Jones M, Robinson R, et al: Treatment of lupus nephritis with cyclophosphamide . Lancet 2:846-849, 1970. 17. Snaith ML, Holt JM, Oliver DO, et al: Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil . Br Med J 2:197-201, 1973.Crossref 18. Drinkard JP, Stanley TM, Dornfield L, et al: Azathioprine and prednisone in the treatment of adults with lupus nephritis: Clinical, histological, and immunological changes with therapy . Medicine 49:411-432, 1970.Crossref 19. Donadio JV, Holley KE, Wagoner RL, et al: Treatment of lupus nephritis with prednisone and combined prednisone and azathioprine . Ann Intern Med 77:829-835, 1972.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: May 1, 1976

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