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Australia Antigen and Hepatitis: Studies in Asymptomatic People and Lepromatous Leprosy Patient

Australia Antigen and Hepatitis: Studies in Asymptomatic People and Lepromatous Leprosy Patient Abstract Australia antigen is intimately associated with a hepatitis virus. It is found in the blood of many individuals who have acute viral hepatitis and in some patients with chronic diseases (ie, some forms of leukemia, Down's syndrome, etc) who have a form of chronic anicteric hepatitis. It is also found in relatively high frequency in apparently normal people living in the tropics, and in even higher frequency in patients with lepromatous leprosy who reside in these areas. Patients with lepromatous leprosy who have the antigen in their blood do not have acute hepatitis, but do have slightly elevated serum glutamic pyruvic transaminase levels. We could not detect any clinical or biochemical evidence of liver abnormality in the apparently normal individuals with Australia antigen. References 1. Blumberg, B.S.: Polymorphisms of Serum Proteins and the Development of Isoprecipitins in Transfused Patients , Bull NY Acad Med 40:377-386 ( (May) ) 1964. 2. Blumberg, B.S.; Alter, H.J.; and Visnich, S.: A "New" Antigen in Leukemia Sera , JAMA 191: 541-546 ( (Feb 15) ) 1965.Crossref 3. Blumberg, B.S., et al: A Serum Antigen (Australia Antigen) in Down's Syndrome, Leukemia and Hepatitis , Ann Intern Med 66:924-931 ( (May) ) 1967.Crossref 4. Blumberg, B.S.; Sutnick, A.I.; and London, W.T.: Hepatitis and Leukemia: Their Relation to Australia Antigen , Bull NY Acad Med 44:1566-1586 ( (Dec) ) 1968. 5. London, W.T.; Sutnick, A.I.; and Blumberg, B.S.: Australia Antigen and Acute Viral Hepatitis , Ann Intern Med 70:55-59 ( (Jan) ) 1969.Crossref 6. Blumberg, B.S.: An Inherited Serum Isoantigen in Leukemia and Down's Syndrome , J Clin Invest 45:988 ( (June) ) 1966. 7. Sutnick, A.I., et al: Anicteric Hepatitis Associated With Australia Antigen: Occurrence in Patients With Down's Syndrome , JAMA 205:670-674 ( (Sept 2) ) 1968.Crossref 8. London, W.T., et al: Australia Antigen Associated Hepatitis Epidemic in a Hemodialysis Unit: The Au Test , Clin Res 16:567 ( (Dec) ) 1968. 9. London, W.T., et al: An Epidemic of Hepatitis in a Chronic Hemodialysis Unit: Australia Antigen and Difference in Host Response , New Eng J Med 281:571-578 ( (Sept 11) ) 1969.Crossref 10. Blumberg, B.S., et al: Association Between Lepromatous Leprosy and Australia Antigen , Lancet 2:173-176 ( (July) ) 1967.Crossref 11. Okochi, K., and Murakami, S.: Observations on Australia Antigen in Japanese , Vox Sang 15: 374-385, 1968.Crossref 12. Bayer, M.E.; Blumberg, B.S.; and Werner, B.: Particles Associated With Australia Antigen in the Sera of Patients With Leukemia, Down's Syndrome and Hepatitis , Nature 218:1057-1059 ( (June 15) ) 1968.Crossref 13. Millman, I., et al: Australia Antigen Detected in the Nuclei of Liver Cells of Patients With Viral Hepatitis Detected by the Fluorescent Antibody Technique , Nature 222:181-184 ( (April 12) ) 1969.Crossref 14. Dixon, W.J., and Massey, F.J.: Introduction to Statistical Analysis , New York: McGraw-Hill Book Co., Inc., 1957. 15. Blumberg, B.S., and Riddell, N.M.: Inherited Antigenic Differences in Human Serum Beta-Lipoproteins: A Second Antiserum , J Clin Invest 42: 867-875 ( (Feb) ) 1963.Crossref 16. Melartin, L., and Blumberg, B.S.: Production of Antibody Against "Australia Antigen" in Rabbits , Nature 210:1340-1341 ( (June) ) 1966.Crossref 17. Conard, R.A., et al: Medical Survey of the People of Rongelap and Utirik Islands Nine and Ten Years After Exposure to Fallout Radiation (March, 1963 and March, 1964) , Upton, NY: Brook-haven National Laboratory, 1965. 18. Blumberg, B.S.; Sutnick, A.I.; and London, W.T.: Australia Antigen and Hepatitis , JAMA 207: 1895-1896 ( (March 10) ) 1969.Crossref 19. Sutnick, A.I.; London, W.T.; and Blumberg, B.S.: Australia Antigen and the Quest for a Hepatitis Virus , Amer J Dig Dis 14:189-194 ( (March) ) 1969.Crossref 20. Newell, K.W.: An Epidemiologist's View of Leprosy , Bull WHO 34:827-857 (No. (6) ) 1966. 21. Waldorf, D.S., et al: Impaired Delayed Hypersensitivity in Patients With Lepromatous Leprosy , Lancet 2:773-776 ( (Oct 8) ) 1966.Crossref 22. Bullock, W.E.: Studies of Immune Mechanisms in Leprosy: I. Depression of Delayed Allergic Response , New Eng J Med 278:298-304 ( (Feb 8) ) 1968.Crossref 23. Hart, P.D., and Rees, R.J.W.: Lepromin and Kveim Antigen Reactivity in Man and Their Relation to Tuberculin Reactivity , Brit Med Bull 23: 80-85 ( (Jan) ) 1967. 24. Sheagren, J.N., et al: Immunologic Reactivity in Patients With Leprosy , Ann Intern Med 70:295-302 ( (Feb) ) 1969.Crossref 25. Blumberg, B.S., et al: Family Studies of a Human Serum Isoantigen System (Australia Antigen) , Amer J Hum Genet 18:594-608 ( (Nov) ) 1966. 26. Blumberg, B.S., et al: Hepatitis and Australia Antigen: Autosomal Recessive Inheritance of Susceptibility to Infection in Humans , Proc Nat Acad Sci 62:1108-1115 ( (April) ) 1969.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Australia Antigen and Hepatitis: Studies in Asymptomatic People and Lepromatous Leprosy Patient

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References (28)

Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1970.00310020093010
Publisher site
See Article on Publisher Site

Abstract

Abstract Australia antigen is intimately associated with a hepatitis virus. It is found in the blood of many individuals who have acute viral hepatitis and in some patients with chronic diseases (ie, some forms of leukemia, Down's syndrome, etc) who have a form of chronic anicteric hepatitis. It is also found in relatively high frequency in apparently normal people living in the tropics, and in even higher frequency in patients with lepromatous leprosy who reside in these areas. Patients with lepromatous leprosy who have the antigen in their blood do not have acute hepatitis, but do have slightly elevated serum glutamic pyruvic transaminase levels. We could not detect any clinical or biochemical evidence of liver abnormality in the apparently normal individuals with Australia antigen. References 1. Blumberg, B.S.: Polymorphisms of Serum Proteins and the Development of Isoprecipitins in Transfused Patients , Bull NY Acad Med 40:377-386 ( (May) ) 1964. 2. Blumberg, B.S.; Alter, H.J.; and Visnich, S.: A "New" Antigen in Leukemia Sera , JAMA 191: 541-546 ( (Feb 15) ) 1965.Crossref 3. Blumberg, B.S., et al: A Serum Antigen (Australia Antigen) in Down's Syndrome, Leukemia and Hepatitis , Ann Intern Med 66:924-931 ( (May) ) 1967.Crossref 4. Blumberg, B.S.; Sutnick, A.I.; and London, W.T.: Hepatitis and Leukemia: Their Relation to Australia Antigen , Bull NY Acad Med 44:1566-1586 ( (Dec) ) 1968. 5. London, W.T.; Sutnick, A.I.; and Blumberg, B.S.: Australia Antigen and Acute Viral Hepatitis , Ann Intern Med 70:55-59 ( (Jan) ) 1969.Crossref 6. Blumberg, B.S.: An Inherited Serum Isoantigen in Leukemia and Down's Syndrome , J Clin Invest 45:988 ( (June) ) 1966. 7. Sutnick, A.I., et al: Anicteric Hepatitis Associated With Australia Antigen: Occurrence in Patients With Down's Syndrome , JAMA 205:670-674 ( (Sept 2) ) 1968.Crossref 8. London, W.T., et al: Australia Antigen Associated Hepatitis Epidemic in a Hemodialysis Unit: The Au Test , Clin Res 16:567 ( (Dec) ) 1968. 9. London, W.T., et al: An Epidemic of Hepatitis in a Chronic Hemodialysis Unit: Australia Antigen and Difference in Host Response , New Eng J Med 281:571-578 ( (Sept 11) ) 1969.Crossref 10. Blumberg, B.S., et al: Association Between Lepromatous Leprosy and Australia Antigen , Lancet 2:173-176 ( (July) ) 1967.Crossref 11. Okochi, K., and Murakami, S.: Observations on Australia Antigen in Japanese , Vox Sang 15: 374-385, 1968.Crossref 12. Bayer, M.E.; Blumberg, B.S.; and Werner, B.: Particles Associated With Australia Antigen in the Sera of Patients With Leukemia, Down's Syndrome and Hepatitis , Nature 218:1057-1059 ( (June 15) ) 1968.Crossref 13. Millman, I., et al: Australia Antigen Detected in the Nuclei of Liver Cells of Patients With Viral Hepatitis Detected by the Fluorescent Antibody Technique , Nature 222:181-184 ( (April 12) ) 1969.Crossref 14. Dixon, W.J., and Massey, F.J.: Introduction to Statistical Analysis , New York: McGraw-Hill Book Co., Inc., 1957. 15. Blumberg, B.S., and Riddell, N.M.: Inherited Antigenic Differences in Human Serum Beta-Lipoproteins: A Second Antiserum , J Clin Invest 42: 867-875 ( (Feb) ) 1963.Crossref 16. Melartin, L., and Blumberg, B.S.: Production of Antibody Against "Australia Antigen" in Rabbits , Nature 210:1340-1341 ( (June) ) 1966.Crossref 17. Conard, R.A., et al: Medical Survey of the People of Rongelap and Utirik Islands Nine and Ten Years After Exposure to Fallout Radiation (March, 1963 and March, 1964) , Upton, NY: Brook-haven National Laboratory, 1965. 18. Blumberg, B.S.; Sutnick, A.I.; and London, W.T.: Australia Antigen and Hepatitis , JAMA 207: 1895-1896 ( (March 10) ) 1969.Crossref 19. Sutnick, A.I.; London, W.T.; and Blumberg, B.S.: Australia Antigen and the Quest for a Hepatitis Virus , Amer J Dig Dis 14:189-194 ( (March) ) 1969.Crossref 20. Newell, K.W.: An Epidemiologist's View of Leprosy , Bull WHO 34:827-857 (No. (6) ) 1966. 21. Waldorf, D.S., et al: Impaired Delayed Hypersensitivity in Patients With Lepromatous Leprosy , Lancet 2:773-776 ( (Oct 8) ) 1966.Crossref 22. Bullock, W.E.: Studies of Immune Mechanisms in Leprosy: I. Depression of Delayed Allergic Response , New Eng J Med 278:298-304 ( (Feb 8) ) 1968.Crossref 23. Hart, P.D., and Rees, R.J.W.: Lepromin and Kveim Antigen Reactivity in Man and Their Relation to Tuberculin Reactivity , Brit Med Bull 23: 80-85 ( (Jan) ) 1967. 24. Sheagren, J.N., et al: Immunologic Reactivity in Patients With Leprosy , Ann Intern Med 70:295-302 ( (Feb) ) 1969.Crossref 25. Blumberg, B.S., et al: Family Studies of a Human Serum Isoantigen System (Australia Antigen) , Amer J Hum Genet 18:594-608 ( (Nov) ) 1966. 26. Blumberg, B.S., et al: Hepatitis and Australia Antigen: Autosomal Recessive Inheritance of Susceptibility to Infection in Humans , Proc Nat Acad Sci 62:1108-1115 ( (April) ) 1969.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1970

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