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Effects of Folic Acid Metabolism on Serum Cholesterol Levels

Effects of Folic Acid Metabolism on Serum Cholesterol Levels Abstract Low serum cholesterol levels have been reported to occur in patients with macrocytic anemia due to folic acid or vitamin B12 deficiency or both. Dietary fat intake did not appear to be in any way related to the serum cholesterol levels. The lipoprotein distribution pattern was determined in few patients, and the result showed the β-lipoprotein levels to be decreased in all fractions, with the most significant depression in the Sf 0-12 fraction, which carries most of the serum cholesterol. A definite statistical correlation between serum cholesterol levels and serum folate levels up to 6.2 mug/ml has been established. Significantly lower correlation was obtained for vitamin B12 deficiency, even though in all patients with very severe vitamin B12 deficiency, serum cholesterol patterns resembling those of folate deficiency have been observed. A return of serum cholesterol to normal levels has been observed in all patients after folate administration. References 1. Bazzano, G.: Serum Cholesterol Levels in Macrocytic Anemia: Relationships to Folic Acid and Vitamin B12 , Amer J Clin Nutr 16:391 ( (April) ) 1965. 2. Herbert, V.: The Assay and Nature of Folic Acid Activity in the Human Serum , J Clin Invest 40:81-89 ( (Jan) ) 1961.Crossref 3. Abell, L.L., et al: Simplified Method for Determination of Total Cholesterol in Serum , J Biol Chem 195:357-366 ( (March) ) 1952. 4. Gofman, J.W., and DeLalla, L.F.: " Ultracentrifugal Analysis of Serum Lipoproteins ," in Glick, D. (ed.): Methods of Biochemical Analysis , New York: Interscience Publishers, Inc., 1954, vol 1, pp 459-478. 5. Johnstone, M.J.; Kemp, J.H.; and Hibbard, E.D.: A Colorimetric Method for the Estimation of Urinary Formiminoglutamic Acid , Clin Chim Acta 12:440-444 ( (Sept) ) 1965.Crossref 6. Rosenthal, H.L., and Sarett, H.P.: The Determination of Vitamin B12 Activity in Human Serum , J Biol Chem 199:433-442 ( (Nov) ) 1952. 7. Lau, K., et al: Measurement of Serum Vitamin B12 Level Using Radioisotope Dilution and Coated Charcoal , Blood 26:202-214 ( (Aug) ) 1965. 8. Olson, R.E., et al: Effect of Amino Acid Intake Upon Serum Cholesterol in Man , J Clin Invest 43:1233 ( (June) ) 1964. 9. Stanley, J.: The Essence of Biometry , Montreal: McGill University Press, 1963, pp 90-100. 10. Broun, G.O.; Pelkan, K.F.; and Riggs, M., cited by Muller, G.L.: The Relation of Cholesterol, Lechitin, Phosphorus and Fatty Acids to the Remission of Pernicious Anemia , Amer J Med Sci 179:316-337 ( (March) ) 1930.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Effects of Folic Acid Metabolism on Serum Cholesterol Levels

Archives of Internal Medicine , Volume 124 (6) – Dec 1, 1969

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1969.00300220062011
Publisher site
See Article on Publisher Site

Abstract

Abstract Low serum cholesterol levels have been reported to occur in patients with macrocytic anemia due to folic acid or vitamin B12 deficiency or both. Dietary fat intake did not appear to be in any way related to the serum cholesterol levels. The lipoprotein distribution pattern was determined in few patients, and the result showed the β-lipoprotein levels to be decreased in all fractions, with the most significant depression in the Sf 0-12 fraction, which carries most of the serum cholesterol. A definite statistical correlation between serum cholesterol levels and serum folate levels up to 6.2 mug/ml has been established. Significantly lower correlation was obtained for vitamin B12 deficiency, even though in all patients with very severe vitamin B12 deficiency, serum cholesterol patterns resembling those of folate deficiency have been observed. A return of serum cholesterol to normal levels has been observed in all patients after folate administration. References 1. Bazzano, G.: Serum Cholesterol Levels in Macrocytic Anemia: Relationships to Folic Acid and Vitamin B12 , Amer J Clin Nutr 16:391 ( (April) ) 1965. 2. Herbert, V.: The Assay and Nature of Folic Acid Activity in the Human Serum , J Clin Invest 40:81-89 ( (Jan) ) 1961.Crossref 3. Abell, L.L., et al: Simplified Method for Determination of Total Cholesterol in Serum , J Biol Chem 195:357-366 ( (March) ) 1952. 4. Gofman, J.W., and DeLalla, L.F.: " Ultracentrifugal Analysis of Serum Lipoproteins ," in Glick, D. (ed.): Methods of Biochemical Analysis , New York: Interscience Publishers, Inc., 1954, vol 1, pp 459-478. 5. Johnstone, M.J.; Kemp, J.H.; and Hibbard, E.D.: A Colorimetric Method for the Estimation of Urinary Formiminoglutamic Acid , Clin Chim Acta 12:440-444 ( (Sept) ) 1965.Crossref 6. Rosenthal, H.L., and Sarett, H.P.: The Determination of Vitamin B12 Activity in Human Serum , J Biol Chem 199:433-442 ( (Nov) ) 1952. 7. Lau, K., et al: Measurement of Serum Vitamin B12 Level Using Radioisotope Dilution and Coated Charcoal , Blood 26:202-214 ( (Aug) ) 1965. 8. Olson, R.E., et al: Effect of Amino Acid Intake Upon Serum Cholesterol in Man , J Clin Invest 43:1233 ( (June) ) 1964. 9. Stanley, J.: The Essence of Biometry , Montreal: McGill University Press, 1963, pp 90-100. 10. Broun, G.O.; Pelkan, K.F.; and Riggs, M., cited by Muller, G.L.: The Relation of Cholesterol, Lechitin, Phosphorus and Fatty Acids to the Remission of Pernicious Anemia , Amer J Med Sci 179:316-337 ( (March) ) 1930.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Dec 1, 1969

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