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Thyrocalcitonin Activity in Metastatic Medullary Thyroid Carcinoma: Further Evidence for its Parafollicular Cell Origin

Thyrocalcitonin Activity in Metastatic Medullary Thyroid Carcinoma: Further Evidence for its... Abstract The distinctive histologic entity, medullary (solid) carcinoma of the thyroid,1 has attracted much attention lately because of the diverse endocrinologic syndromes with which it may be associated. Several authors have pointed out the coincidental finding of bilateral pheochromocytoma,2,3 parathyroid adenoma,4 the carcinoid syndrome,5 Cushing's syndrome,6 and diabetes mellitus3 in patients with medullary carcinoma of the thyroid or in their immediate relatives or in both. However, the full endocrine potential of this neoplasm is only now becoming clear with the recent observations that the tumor tissue itself may be the site of elaboration of various humoral substances, namely, serotonin,7 prostaglandins,8 and thyrocalcitonin.9 Thyrocalcitonin (calcitonin) activity in the human thyroid gland was demonstrated by Aliapoulios et al,10 and subsequent evidence11,12 indicated that the parafollicular cell may be the site of its production. Because the histologic features of medullary carcinoma of the References 1. Hazard, J.B.; Hawk, W.A.; and Crile, G., Jr.: Medullary (Solid) Carcinoma of the Thyroid: A Clinicopathologic Entity , J Clin Endocr 19:152-161 ( (Jan) ) 1959.Crossref 2. Sipple, J.H.: The Association of Pheochromocytoma With Carcinoma of the Thyroid Gland , Amer J Med 31:163-166 ( (July) ) 1961.Crossref 3. Block, M.A., et al: Familial Medullary Carcinoma of the Thyroid , Ann Surg 166:403-412 ( (Sept) ) 1967.Crossref 4. Manning, P.C., Jr., et al: Pheochromocytoma, Hyperparathyroidism and Thyroid Carcinoma Occurring Coincidentally: Report of a Case , New Eng J Med 268:68-72 ( (Jan 10) ) 1963.Crossref 5. Moertel, C.G., et al: "Malignant Carcinoid Syndrome" Associated With Noncarcinoid Tumors , New Eng J Med 273:244-248 ( (July 29) ) 1965.Crossref 6. Donahower, G.; Schumacher, O.P.; and Hazard, J.B.: Two Cases of Medullary Thyroid Carcinoma Causing Cushing's Syndrome , Clin Res 14:430 ( (Oct) ) 1966. 7. Ljungberg, O.; Cederquist, E.; and von Studnitz, W.: Medullary Thyroid Carcinoma and Phaeochromocytoma: A Familial Chromaffinomatosis , Brit Med J 1:279-281 ( (Feb 4) ) 1967.Crossref 8. Williams, E.D.; Karim, S.M.M.; and Sandler, M.: Prostaglandin Secretion by Medullary Carcinoma of the Thyroid: A Possible Cause of the Associated Diarrhoea , Lancet 1:22-23 ( (Jan 6) ) 1968.Crossref 9. Meyer, J.S., and Abdel-Bari, W.: Granules and Thyrocalcitonin-like Activity in Medullary Carcinoma of the Thyroid Gland , New Eng J Med 278: 523-529 ( (March 7) ) 1968.Crossref 10. Aliapoulios, M.A.; Voelkel, E.F.; and Munson, P.L.: Assay of Human Thyroid Glands for Thyrocalcitonin Activity , J Clin Endocr 26:897-901 ( (Aug) ) 1966.Crossref 11. Bauer, W.C., and Teitelbaum, S.L.: Thyrocalcitonin Activity of Particulate Fractions of the Thyroid Gland , Lab Invest 15:323-329 ( (Jan) ) 1966. 12. Bussolati, G., and Pearse, A.G.: Immunofluorescent Localization of Calcitonin in the "C" Cells of Pig and Dog Thyroid , J Endocr 37:205-209 ( (Feb) ) 1967.Crossref 13. Williams, E.D.: Histogenesis of Medullary Carcinoma of the Thyroid , J Clin Path 19:114-118 ( (March) ) 1966.Crossref 14. Melvin, K.E.W., and Tashjian, A.H., Jr.: The Syndrome of Excessive Thyrocalcitonin Produced by Medullary Carcinoma of the Thyroid , Proc Nat Acad Sci USA 59:1216-1222 ( (April) ) 1968.Crossref 15. Hirsch, P.F.; Voelkel, E.F.; and Munson, P.L.: Thyrocalcitonin: Hypocalcemic Hypophosphatemic Principle of the Thyroid Gland , Science 146:412-413 ( (Oct 16) ) 1964.Crossref 16. Copp, D.H.: Simple and Precise Micromethod for EDTA Titration of Calcium , J Lab Clin Med 61:1029-1037 ( (June) ) 1963. 17. Horn, R.C., Jr.: Carcinoma of Thyroid: Description of Distinctive Morphological Variant and Report of 7 Cases , Cancer 4:697-707 ( (July) ) 1951.Crossref 18. Williams, E.D.; Brown, C.L.; and Doniach, I.: Pathological and Clinical Findings in a Series of 67 Cases of Medullary Carcinoma of the Thyroid , J Clin Path 19:103-113 ( (March) ) 1966.Crossref 19. Ibanez, M.L., et al: Solid Carcinoma of the Thyroid Gland: Analysis of 53 Cases , Cancer 20: 706-723 ( (May) ) 1967.Crossref 20. Nourok, D.S.: Familial Pheochromocytoma and Thyroid Carcinoma , Ann Intern Med 60: 1028-1040 ( (June) ) 1964.Crossref 21. Copp, D.H., and Davidson, A.G.: Direct Humoral Control of Parathyroid Function in the Dog , Proc Soc Exp Biol Med 107:342-344 ( (June) ) 1961.Crossref 22. Hirsch, P.F.; Gauthier, G.F.; and Munson, P.L.: Thyroid Hypocalcemic Principle and Recurrent Laryngeal Nerve Injury as Factors Affecting the Response to Parathyroidectomy in Rats , Endocrinology 73:244-252 ( (Aug) ) 1963.Crossref 23. Copp, D.H.; Cockcroft, D.W.; and Kueh, Y.: Ultimobranchial Origin of Calcitonin: Hypocalcemic Effect of Extracts From Chicken Glands , Canad J Physiol Pharmacol 45:1095-1099 ( (Nov) ) 1967.Crossref 24. Tauber, S.D.: The Ultimobranchial Origin of Thyrocalcitonin , Proc Nat Acad Sci USA 58:1684-1687 ( (Oct 15) ) 1967.Crossref 25. Mazzuoli, G.F.; Coen, G.; and Baschieri, L.: Thyrocalcitonin-Excess Syndrome , Lancet 2:1192-1193 ( (Nov 26) ) 1966.Crossref 26. Chimènes, H., and Klotz, H.P.: Thyrocalcitonin-Excess Syndrome , Lancet 1:111 ( (Jan 14) ) 1967.Crossref 27. Foster, G.V., et al: Effect of Thyrocalcitonin in Man , Lancet 1:107-109 ( (Jan 15) ) 1966.Crossref 28. Kaplan, E.L., et al: Calcitonin-like Responses in Man During Thyroid Surgery , J Clin Endocr 28: 740-745 ( (May) ) 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Thyrocalcitonin Activity in Metastatic Medullary Thyroid Carcinoma: Further Evidence for its Parafollicular Cell Origin

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References (28)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1969.00300140069015
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Abstract

Abstract The distinctive histologic entity, medullary (solid) carcinoma of the thyroid,1 has attracted much attention lately because of the diverse endocrinologic syndromes with which it may be associated. Several authors have pointed out the coincidental finding of bilateral pheochromocytoma,2,3 parathyroid adenoma,4 the carcinoid syndrome,5 Cushing's syndrome,6 and diabetes mellitus3 in patients with medullary carcinoma of the thyroid or in their immediate relatives or in both. However, the full endocrine potential of this neoplasm is only now becoming clear with the recent observations that the tumor tissue itself may be the site of elaboration of various humoral substances, namely, serotonin,7 prostaglandins,8 and thyrocalcitonin.9 Thyrocalcitonin (calcitonin) activity in the human thyroid gland was demonstrated by Aliapoulios et al,10 and subsequent evidence11,12 indicated that the parafollicular cell may be the site of its production. Because the histologic features of medullary carcinoma of the References 1. Hazard, J.B.; Hawk, W.A.; and Crile, G., Jr.: Medullary (Solid) Carcinoma of the Thyroid: A Clinicopathologic Entity , J Clin Endocr 19:152-161 ( (Jan) ) 1959.Crossref 2. Sipple, J.H.: The Association of Pheochromocytoma With Carcinoma of the Thyroid Gland , Amer J Med 31:163-166 ( (July) ) 1961.Crossref 3. Block, M.A., et al: Familial Medullary Carcinoma of the Thyroid , Ann Surg 166:403-412 ( (Sept) ) 1967.Crossref 4. Manning, P.C., Jr., et al: Pheochromocytoma, Hyperparathyroidism and Thyroid Carcinoma Occurring Coincidentally: Report of a Case , New Eng J Med 268:68-72 ( (Jan 10) ) 1963.Crossref 5. Moertel, C.G., et al: "Malignant Carcinoid Syndrome" Associated With Noncarcinoid Tumors , New Eng J Med 273:244-248 ( (July 29) ) 1965.Crossref 6. Donahower, G.; Schumacher, O.P.; and Hazard, J.B.: Two Cases of Medullary Thyroid Carcinoma Causing Cushing's Syndrome , Clin Res 14:430 ( (Oct) ) 1966. 7. Ljungberg, O.; Cederquist, E.; and von Studnitz, W.: Medullary Thyroid Carcinoma and Phaeochromocytoma: A Familial Chromaffinomatosis , Brit Med J 1:279-281 ( (Feb 4) ) 1967.Crossref 8. Williams, E.D.; Karim, S.M.M.; and Sandler, M.: Prostaglandin Secretion by Medullary Carcinoma of the Thyroid: A Possible Cause of the Associated Diarrhoea , Lancet 1:22-23 ( (Jan 6) ) 1968.Crossref 9. Meyer, J.S., and Abdel-Bari, W.: Granules and Thyrocalcitonin-like Activity in Medullary Carcinoma of the Thyroid Gland , New Eng J Med 278: 523-529 ( (March 7) ) 1968.Crossref 10. Aliapoulios, M.A.; Voelkel, E.F.; and Munson, P.L.: Assay of Human Thyroid Glands for Thyrocalcitonin Activity , J Clin Endocr 26:897-901 ( (Aug) ) 1966.Crossref 11. Bauer, W.C., and Teitelbaum, S.L.: Thyrocalcitonin Activity of Particulate Fractions of the Thyroid Gland , Lab Invest 15:323-329 ( (Jan) ) 1966. 12. Bussolati, G., and Pearse, A.G.: Immunofluorescent Localization of Calcitonin in the "C" Cells of Pig and Dog Thyroid , J Endocr 37:205-209 ( (Feb) ) 1967.Crossref 13. Williams, E.D.: Histogenesis of Medullary Carcinoma of the Thyroid , J Clin Path 19:114-118 ( (March) ) 1966.Crossref 14. Melvin, K.E.W., and Tashjian, A.H., Jr.: The Syndrome of Excessive Thyrocalcitonin Produced by Medullary Carcinoma of the Thyroid , Proc Nat Acad Sci USA 59:1216-1222 ( (April) ) 1968.Crossref 15. Hirsch, P.F.; Voelkel, E.F.; and Munson, P.L.: Thyrocalcitonin: Hypocalcemic Hypophosphatemic Principle of the Thyroid Gland , Science 146:412-413 ( (Oct 16) ) 1964.Crossref 16. Copp, D.H.: Simple and Precise Micromethod for EDTA Titration of Calcium , J Lab Clin Med 61:1029-1037 ( (June) ) 1963. 17. Horn, R.C., Jr.: Carcinoma of Thyroid: Description of Distinctive Morphological Variant and Report of 7 Cases , Cancer 4:697-707 ( (July) ) 1951.Crossref 18. Williams, E.D.; Brown, C.L.; and Doniach, I.: Pathological and Clinical Findings in a Series of 67 Cases of Medullary Carcinoma of the Thyroid , J Clin Path 19:103-113 ( (March) ) 1966.Crossref 19. Ibanez, M.L., et al: Solid Carcinoma of the Thyroid Gland: Analysis of 53 Cases , Cancer 20: 706-723 ( (May) ) 1967.Crossref 20. Nourok, D.S.: Familial Pheochromocytoma and Thyroid Carcinoma , Ann Intern Med 60: 1028-1040 ( (June) ) 1964.Crossref 21. Copp, D.H., and Davidson, A.G.: Direct Humoral Control of Parathyroid Function in the Dog , Proc Soc Exp Biol Med 107:342-344 ( (June) ) 1961.Crossref 22. Hirsch, P.F.; Gauthier, G.F.; and Munson, P.L.: Thyroid Hypocalcemic Principle and Recurrent Laryngeal Nerve Injury as Factors Affecting the Response to Parathyroidectomy in Rats , Endocrinology 73:244-252 ( (Aug) ) 1963.Crossref 23. Copp, D.H.; Cockcroft, D.W.; and Kueh, Y.: Ultimobranchial Origin of Calcitonin: Hypocalcemic Effect of Extracts From Chicken Glands , Canad J Physiol Pharmacol 45:1095-1099 ( (Nov) ) 1967.Crossref 24. Tauber, S.D.: The Ultimobranchial Origin of Thyrocalcitonin , Proc Nat Acad Sci USA 58:1684-1687 ( (Oct 15) ) 1967.Crossref 25. Mazzuoli, G.F.; Coen, G.; and Baschieri, L.: Thyrocalcitonin-Excess Syndrome , Lancet 2:1192-1193 ( (Nov 26) ) 1966.Crossref 26. Chimènes, H., and Klotz, H.P.: Thyrocalcitonin-Excess Syndrome , Lancet 1:111 ( (Jan 14) ) 1967.Crossref 27. Foster, G.V., et al: Effect of Thyrocalcitonin in Man , Lancet 1:107-109 ( (Jan 15) ) 1966.Crossref 28. Kaplan, E.L., et al: Calcitonin-like Responses in Man During Thyroid Surgery , J Clin Endocr 28: 740-745 ( (May) ) 1968.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Apr 1, 1969

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