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Nephrotic Syndrome With Use of Ammoniated Mercury

Nephrotic Syndrome With Use of Ammoniated Mercury Abstract IT IS well known that mercury can affect renal function. Organic mercurials can produce diuresis, and organic or inorganic mercurial compounds taken in therapeutic or excessive dosages may cause tubular necrosis, proteinuria, or the nephrotic syndrome. This syndrome has been associated with mercurial diuretics1-4; mercurous chloride in calomel-containing powders5,6; the mercury salt of fulminic acid 7; vapor from paint additives containing mercuric chloride, mercury, and phenol mercury 1; the protiodide of mercury8; and vapor in the mercury industry containing mercury, mercurous chloride, mercuric chloride, mercuric oxide, and phenyl mercury acetate.9 Ammoniated mercury, an inorganic compound whose formula is HgNH2CL, has been implicated in the production of proteinuria10-12 and the nephrotic syndrome 1,13 14 (Table 1). Following is a report of a case of nephrotic syndrome associated with use of ammoniated mercury. Report of a Case A 24-year-old white man, a bank cashier from References 1. Becker, C.G., et al: Nephrotic Syndrome After Contact With Mercury , Arch Intern Med 110: 178-186 ( (Aug) ) 1962.Crossref 2. Munck, O., and Nissen, N.I.: Development of Nephrotic Syndrome During Treatment With Mercurial Diuretics , Acta Med Scand 153:307-313, 1956.Crossref 3. Thayer, J.M.; Gleckler, W.J.; and Holmes, R.O.: The Development of the Nephrotic Syndrome During the Course of Congestive Heart Failure , Ann Intern Med 54:1013-1025 ( (May) ) 1961.Crossref 4. Cameron, J.S., and Trounce, J.R.: Membranous Glomerulonephritis and the Nephrotic Syndrome Appearing During Mersalyl Therapy , Guy Hosp Rep 114:101-107, 1965. 5. Wilson, V.K.; Thomson, M.L.; and Holzel, A.: Mercury Nephrosis in Young Children With Special Reference to Teething Powders Containing Mercury , Brit Med J 1:358-360 ( (Feb 16) ) 1952.Crossref 6. Farquhar, H.G.: Mercurial Poisoning in Early Childhood , Lancet 2:1186-1187 ( (Dec 5) ) 1953.Crossref 7. Riva, G.: Zur Frage der chronischen Quecksilbernephrose , Helv Med Acta 12:539-545, 1945. 8. Warren, D.E.: Nephrotic Syndrome Caused by Protiodide of Mercury , Arch Derm 91:240-242 ( (Mar) ) 1965.Crossref 9. Kazantzis, G., et al: Albuminuria and the Nephrotic Syndrome Following Exposure to Mercury and Its Compounds , Quart J Med 31:403-418 ( (Oct) ) 1962. 10. De Levie, M.: Chronische Kwikvergiftiging Door Sproetenzalf , Nederl T Geneesk 82:4448-4453 ( (Sept) ) 1938. 11. Hermans, E.H., Sr.: Klinische Lessen: Kwikvergiftiging , Nederl T Geneesk 100:1830-1835 ( (June 30) ) 1956. 12. Young, E.: Ammoniated Mercury Poisoning , Brit J Derm 72:449-455 ( (Dec) ) 1960.Crossref 13. Mandema, E., et al: Mercury and the Kidney , Lancet 1:1266 ( (June 8) ) 1963.Crossref 14. Williams, N.E., and Bridge, H.G.: Nephrotic Syndrome After the Application of Mercury Ointment , Lancet 2:602 ( (Sept 20) ) 1958.Crossref 15. Berlin, N.I., et al: Folic Acid Antagonists: Effects on the Cell and the Patient , Ann Intern Med 59:931-956 ( (Dec) ) 1963.Crossref 16. Taylor, R.D.: Nephrotic Syndrome: Treatment With ACTH and Nitrogen Mustard , Med Clin N Amer 39:995-1000 ( (July) ) 1955. 17. Friberg, L.: Synpunkter på kronisk förgifning med oorganiskt kvicksilver i anledning av iakttagna fall , Nord Hyg T , 1951, pp 240-248. 18. Friberg, L.; Hammerström, S.; and Nyström, A.: Kidney Injury After Chronic Exposure to Inorganic Mercury , Arch Indust Hyg Occup Med 8: 149-153 ( (Aug) ) 1953. 19. Goldwater, L.J.: Correspondence: Kidney Injury After Chronic Exposure to Inorganic Mercury , Arch Indust Hyg Occup Med 8:588 ( (Dec) ) 1953. 20. Zollinger, H.U.: Autoptische und experimentelle Untersuchungen über Lipoidnephrose hervergerufen durch chronische Quecksilbervergiftung , Schweiz Z Allg Path 18:155-169, 1955. 21. Butler, E.A., and Flynn, F.V.: The Proteinuria of Renal Tubular Disorders , Lancet 2:978-980 ( (Nov 8) ) 1958.Crossref 22. Jacobs, M.B.; Ladd, A.C.; and Goldwater, L.J.: Absorption and Excretion of Mercury in Man , Arch Environ Health 9:454-463 ( (Oct) ) 1964.Crossref 23. Goldwater, L.J.; Ladd, A.C.; and Jacobs, M.B.: Absorption and Excretion of Mercury in Man , Arch Environ Health 9:735-741 ( (Dec) ) 1964.Crossref 24. Smith, A.D.M., and Miller, J.W.: Treatment of Inorganic Mercury Poisoning With N-Acetyl-D, L-Penicillamine , Lancet 1:640-642 ( (March 25) ) 1961.Crossref 25. Adams, D.A., et al: Nephrotic Syndrome Associated With Penicillamine Therapy of Wilson's Disease , Amer J Med 36:330-336 ( (Feb) ) 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Nephrotic Syndrome With Use of Ammoniated Mercury

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References (27)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1967.00300040065011
Publisher site
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Abstract

Abstract IT IS well known that mercury can affect renal function. Organic mercurials can produce diuresis, and organic or inorganic mercurial compounds taken in therapeutic or excessive dosages may cause tubular necrosis, proteinuria, or the nephrotic syndrome. This syndrome has been associated with mercurial diuretics1-4; mercurous chloride in calomel-containing powders5,6; the mercury salt of fulminic acid 7; vapor from paint additives containing mercuric chloride, mercury, and phenol mercury 1; the protiodide of mercury8; and vapor in the mercury industry containing mercury, mercurous chloride, mercuric chloride, mercuric oxide, and phenyl mercury acetate.9 Ammoniated mercury, an inorganic compound whose formula is HgNH2CL, has been implicated in the production of proteinuria10-12 and the nephrotic syndrome 1,13 14 (Table 1). Following is a report of a case of nephrotic syndrome associated with use of ammoniated mercury. Report of a Case A 24-year-old white man, a bank cashier from References 1. Becker, C.G., et al: Nephrotic Syndrome After Contact With Mercury , Arch Intern Med 110: 178-186 ( (Aug) ) 1962.Crossref 2. Munck, O., and Nissen, N.I.: Development of Nephrotic Syndrome During Treatment With Mercurial Diuretics , Acta Med Scand 153:307-313, 1956.Crossref 3. Thayer, J.M.; Gleckler, W.J.; and Holmes, R.O.: The Development of the Nephrotic Syndrome During the Course of Congestive Heart Failure , Ann Intern Med 54:1013-1025 ( (May) ) 1961.Crossref 4. Cameron, J.S., and Trounce, J.R.: Membranous Glomerulonephritis and the Nephrotic Syndrome Appearing During Mersalyl Therapy , Guy Hosp Rep 114:101-107, 1965. 5. Wilson, V.K.; Thomson, M.L.; and Holzel, A.: Mercury Nephrosis in Young Children With Special Reference to Teething Powders Containing Mercury , Brit Med J 1:358-360 ( (Feb 16) ) 1952.Crossref 6. Farquhar, H.G.: Mercurial Poisoning in Early Childhood , Lancet 2:1186-1187 ( (Dec 5) ) 1953.Crossref 7. Riva, G.: Zur Frage der chronischen Quecksilbernephrose , Helv Med Acta 12:539-545, 1945. 8. Warren, D.E.: Nephrotic Syndrome Caused by Protiodide of Mercury , Arch Derm 91:240-242 ( (Mar) ) 1965.Crossref 9. Kazantzis, G., et al: Albuminuria and the Nephrotic Syndrome Following Exposure to Mercury and Its Compounds , Quart J Med 31:403-418 ( (Oct) ) 1962. 10. De Levie, M.: Chronische Kwikvergiftiging Door Sproetenzalf , Nederl T Geneesk 82:4448-4453 ( (Sept) ) 1938. 11. Hermans, E.H., Sr.: Klinische Lessen: Kwikvergiftiging , Nederl T Geneesk 100:1830-1835 ( (June 30) ) 1956. 12. Young, E.: Ammoniated Mercury Poisoning , Brit J Derm 72:449-455 ( (Dec) ) 1960.Crossref 13. Mandema, E., et al: Mercury and the Kidney , Lancet 1:1266 ( (June 8) ) 1963.Crossref 14. Williams, N.E., and Bridge, H.G.: Nephrotic Syndrome After the Application of Mercury Ointment , Lancet 2:602 ( (Sept 20) ) 1958.Crossref 15. Berlin, N.I., et al: Folic Acid Antagonists: Effects on the Cell and the Patient , Ann Intern Med 59:931-956 ( (Dec) ) 1963.Crossref 16. Taylor, R.D.: Nephrotic Syndrome: Treatment With ACTH and Nitrogen Mustard , Med Clin N Amer 39:995-1000 ( (July) ) 1955. 17. Friberg, L.: Synpunkter på kronisk förgifning med oorganiskt kvicksilver i anledning av iakttagna fall , Nord Hyg T , 1951, pp 240-248. 18. Friberg, L.; Hammerström, S.; and Nyström, A.: Kidney Injury After Chronic Exposure to Inorganic Mercury , Arch Indust Hyg Occup Med 8: 149-153 ( (Aug) ) 1953. 19. Goldwater, L.J.: Correspondence: Kidney Injury After Chronic Exposure to Inorganic Mercury , Arch Indust Hyg Occup Med 8:588 ( (Dec) ) 1953. 20. Zollinger, H.U.: Autoptische und experimentelle Untersuchungen über Lipoidnephrose hervergerufen durch chronische Quecksilbervergiftung , Schweiz Z Allg Path 18:155-169, 1955. 21. Butler, E.A., and Flynn, F.V.: The Proteinuria of Renal Tubular Disorders , Lancet 2:978-980 ( (Nov 8) ) 1958.Crossref 22. Jacobs, M.B.; Ladd, A.C.; and Goldwater, L.J.: Absorption and Excretion of Mercury in Man , Arch Environ Health 9:454-463 ( (Oct) ) 1964.Crossref 23. Goldwater, L.J.; Ladd, A.C.; and Jacobs, M.B.: Absorption and Excretion of Mercury in Man , Arch Environ Health 9:735-741 ( (Dec) ) 1964.Crossref 24. Smith, A.D.M., and Miller, J.W.: Treatment of Inorganic Mercury Poisoning With N-Acetyl-D, L-Penicillamine , Lancet 1:640-642 ( (March 25) ) 1961.Crossref 25. Adams, D.A., et al: Nephrotic Syndrome Associated With Penicillamine Therapy of Wilson's Disease , Amer J Med 36:330-336 ( (Feb) ) 1964.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Nov 1, 1967

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