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W.B. Bean , C.C. Drevets, J.S. and Chapman (1958)
Chronic Atrophic PolychondritisMedicine, 37
T.R. Harwood (1958)
Diffuse Perichondritis, Chondritis, and IritisArch Path, 64
H.L. Kaplan (1962)
Relapsing Polychondritis: Report of a CaseJAMA, 180
E. Kimura (1963)
Relapsing PolychondritisNaika, 12
F. Jensen (1962)
Polychondritis: Report of the First Danish CaseActa Otolaryng, 54
S.F.: " Jackson (1961)
Some Biochemical Characteristics of Connective Tissue
L.H. Winer (1960)
Chronic Atrophic PolychondritisArch Derm, 81
H.M. Johnson (1963)
Relapsing PolychondritisArch Derm, 88
D.L. Dolan , B.G. Lemmon, S. and Teitelbaum (1966)
Relapsing Polychondritis, Analytical Literature Review and Studies on PathogenesisAmer J Med, 41
R. Von Meyenburg (1936)
�ber ChondromalacieSchweiz Med Wschr, 17
J.A. Tronczynska (1958)
A Rare Case of Systemic Disease of CartilageOtolaryng Pol, 122
D. Megighian (1957)
Contributo allo studio delle collagenosi d'interesse otolaringologicoMinerva Otorinolaring, 7
V.A. McKusick (1962)
Pinnal CalcificationJAMA, 179
R. Degos , J. Guilaine, A. and Decaudin (1960)
Un Cas de Polychondrite Chronique AtrophianteBull Soc Franc Derm Syph, 67
A.C. Hilding (1952)
Syndrome of Joint and Cartilaginous Pathologic Changes With Destructive IridocyclitisArch Intern Med, 89
R.T. McCluskey (1958)
Removal of Cartilage Matrix, in Vivo, by PapainJ Exp Med, 108
J.W. Horns (1962)
Tracheal Collapse in PolychondritisAmer J Roentgen, 87
J. Marshall (1964)
Chronic Atrophic Polychondritis: A South African CaseS Afr Med J, 38
L.E. Glynn (1952)
Conversion of Tissue Polysaccharides to Auto-antigens by Group A, Beta-Haemolytic StreptococciLancet, 2
E.J. Gordon , A.W. Perlman, N. and Schechter (1948)
Diffuse Inflammation of CartilageJ Bone Joint Surg, 30A
R. Jaksch-Wartenhorst (1923)
PolychondropathiaWien Z Inn Med, 6
C. Goldwater (1963)
Relapsing Polychondritis: A Case ReportActa Rheum Scand, 9
F.E. Wiedmann , A.R. Crane, R.J. and Gill (1959)
Systemic Chondromalacia (von Meyenburg's Disease)Bull Ayer Clin Lab, 4
Richard L. Golden (1963)
Relapsing PolychondritisMed Times, 91
S. Bober (1955)
Polychondritis Chronica Atrophicans: Bericht �ber Einen Weiteren FallSchweiz Med Wschr, 85
W. Wagemann (1960)
Die PanchondritisArch Ohr Nas Kehlkopfheilk, 176
N. Di Ferrante (1964)
Precipitins in the Rabbit Produced by Protein Polysaccharide From Bovine Nasal CartilageScience, 143
F.D. Rogers (1955)
Atrophy of Auricular and Nasal Cartilages Following Administration of Chorionic Gonadotropins in a Case or Arthritis Mutilans With the Sicca SyndromeAmer J Med Sci, 229
H.R. Davies (1961)
Atrophic Polychondritis With the Report of a CaseAnn Rheum Dis, 20
A. Kahn (1956)
Generalized Chondritis of Both EarsAnn Otol, 65
F.W. Arundell (1960)
Familial Chronic Atrophic PolychondritisArch Dermat, 82
(1958)
Clinico-Pathological Conference: Yale-New Haven Medical CenterResident Physician, 4
C.M. Pearson , H.M. Kline, V.D. and Newcomer (1690)
Relapsing PolychondritisNew Eng J Med, 263
F.M. Purcelli , A. Nahum, C. and Monell (1962)
Relapsing Polychondritis With Tracheal CollapseAnn Otol, 71
M.A. Verity , W.M. Larson, S.C. and Madden (1963)
Relapsing PolychondritisAmer J Path, 42
T.T. Tsaltas (1958)
Papain-Induced Changes in Rabbit Cartilage: Alterations in Chemical Structure of Cartilage MatrixJ Exp Med, 108
R.L. Kaye (1964)
Relapsing Polychondritis: Clinical and Pathologic Features in Fourteen CasesAnn Intern Med, 60
G. Seifert (1961)
�ber die Chondrolytische Perichondritis (Chondromalcie) Vorwiegen der LuftwegeFrankfurt Z Path, 71
H. Harders (1954)
Beitrag zur Kenntnis Eines Rheumatischen Syndroms mit Allgemeinem Befall des KnorpelsSchweiz Med Wschr, 84
F. Altherr (1936)
�ber Einen Fall von Systematisierter ChondromalacieVirchow Arch Path Anat, 297
L. Thomas (1960)
Comparison of the Effects of Papain and Vitamin A on Cartilage: I. The Effects in RabbitsJ Exp Med, 3
F. Coste (1961)
Polychondritis, Polyarthritis and Gougerot-Sj�gren's SyndromeRev Rheum, 28
M.M.A. Par (1961)
Polychondrite atrophianteBull Soc Franc, 68
L. Thomas (1956)
Reversible Collapse of Rabbit Ears After Intravenous Papain, and Prevention of Recovery by Cortisone.J Exp Med, 104
Abstract RELAPSING polychondritis is a syndrome characterized by intermittent symptoms of cartilaginous inflammation, primarily involving the ears, nose, trachea, bronchi, and costal cartilages; it is frequently associated with conjunctivitis, episcleritis, arthritis, fever, and anemia. Fifty-four cases have been reported and several others referred to in the literature.1-37 Since the original description in 1923 by Jaksch-Wartenhorst1 this syndrome has periodically been the subject of excellent reviews.11,12,23,37 The patient we are reporting presents the typical clinical picture of relapsing polychondritis and is the tenth autopsied case. Unique features of this case are the radiographic picture which developed during an episode of respiratory distress and the findings of cystic medial necrosis of the aorta at autopsy. Report of a Case The patient, a 34-year-oldwhite housewife, developed painful swelling and redness of the bridge of her nose five years before her aadmission to AAnckerhospital, St. Paul. This ddisappeared spontaneously in six References 1. Jaksch-Wartenhorst, R.: Polychondropathia , Wien Z Inn Med 6:93-100, 1923. 2. Altherr, F.: Über Einen Fall von Systematisierter Chondromalacie , Virchow Arch Path Anat 297:445-479, 1936.Crossref 3. Von Meyenburg, R.: Über Chondromalacie , Schweiz Med Wschr 17:1239, 1936. 4. Gordon, E.J.; Perlman, A.W.; and Schechter, N.: Diffuse Inflammation of Cartilage , J Bone Joint Surg 30A:944, 1948. 5. Hilding, A.C.: Syndrome of Joint and Cartilaginous Pathologic Changes With Destructive Iridocyclitis , Arch Intern Med 89:445-453, 1952.Crossref 6. Harders, H.: Beitrag zur Kenntnis Eines Rheumatischen Syndroms mit Allgemeinem Befall des Knorpels , Schweiz Med Wschr 84:712-715, 1954. 7. Rogers, F.D., and Lansbury, J.: Atrophy of Auricular and Nasal Cartilages Following Administration of Chorionic Gonadotropins in a Case or Arthritis Mutilans With the Sicca Syndrome , Amer J Med Sci 229:55-62, 1955.Crossref 8. Bober, S., and Czarniecki, W.: Polychondritis Chronica Atrophicans: Bericht Über Einen Weiteren Fall , Schweiz Med Wschr 85:448, 1955. 9. Harwood, T.R.: Diffuse Perichondritis, Chondritis, and Iritis , Arch Path 64:81-87, 1958. 10. Clinico-Pathological Conference: Yale-New Haven Medical Center , Resident Physician 4:75-88 ( (Aug) ) 1958. 11. Bean, W.B.; Drevets, C.C.; and Chapman, J.S.: Chronic Atrophic Polychondritis , Medicine 37:353-363, 1958.Crossref 12. Pearson, C.M.; Kline, H.M.; and Newcomer, V.D.: Relapsing Polychondritis , New Eng J Med 263:51-58, 1690.Crossref 13. Horns, J.W., and O'Loughlin, B.J.: Tracheal Collapse in Polychondritis , Amer J Roentgen 87:844-846, 1962. 14. Tronczynska, J.A.: A Rare Case of Systemic Disease of Cartilage , Otolaryng Pol 122:89, 1958. 15. Wagemann, W.: Die Panchondritis , Arch Ohr Nas Kehlkopfheilk 176:785, 1960.Crossref 16. Seifert, G., and Strobel, W.: Über die Chondrolytische Perichondritis (Chondromalcie) Vorwiegen der Luftwege , Frankfurt Z Path 71:95-117, 1961. 17. Kaplan, H.L., et al: Relapsing Polychondritis: Report of a Case , JAMA 180:164-166, 1962.Crossref 18. Purcelli, F.M.; Nahum, A.; and Monell, C.: Relapsing Polychondritis With Tracheal Collapse , Ann Otol 71:1120-1128, 1962. 19. Golden, Richard L.: Relapsing Polychondritis , Med Times 91:319-324, 1963. 20. Verity, M.A.; Larson, W.M.; and Madden, S.C.: Relapsing Polychondritis , Amer J Path 42:251-269, 1963. 21. Jensen, F.: Polychondritis: Report of the First Danish Case Acta Otolaryng 54:423-430, 1962.Crossref 22. Johnson, H.M.: Relapsing Polychondritis , Arch Derm 88:651-659, 1963.Crossref 23. Kaye, R.L., and Sones, D.A.: Relapsing Polychondritis: Clinical and Pathologic Features in Fourteen Cases , Ann Intern Med 60:653-664, 1964.Crossref 24. Par, M.M.A., et al: Polychondrite atrophiante , Bull Soc Franc 68:176-178, 1961. 25. Davies, H.R., and Kelsall, A.R.: Atrophic Polychondritis With the Report of a Case , Ann Rheum Dis 20:189-193, 1961.Crossref 26. Arundell, F.W., and Haserick, J.R.: Familial Chronic Atrophic Polychondritis , Arch Dermat 82:439, 1960.Crossref 27. Goldwater, C.: Relapsing Polychondritis: A Case Report , Acta Rheum Scand 9:245, 1963.Crossref 28. Marshall, J., and LeRoux, D.G.: Chronic Atrophic Polychondritis: A South African Case , S Afr Med J 38:527-9, 1964. 29. Winer, L.H., and Kline, H.M.: Chronic Atrophic Polychondritis , Arch Derm 81:469, 1960. 30. McKusick, V.A., and Goodman, R.M.: Pinnal Calcification , JAMA 179:230, 1962.Crossref 31. Kahn, A., Jr., and Kilbury, M.J., Sr.: Generalized Chondritis of Both Ears , Ann Otol 65:615-19, 1956. 32. Kimura, E., et al: Relapsing Polychondritis , Naika 12:11-12, 1963. 33. Megighian, D.: Contributo allo studio delle collagenosi d'interesse otolaringologico , Minerva Otorinolaring 7:223, 1957. 34. Wiedmann, F.E.; Crane, A.R.; and Gill, R.J.: Systemic Chondromalacia (von Meyenburg's Disease) , Bull Ayer Clin Lab 4:45, 1959. 35. Degos, R.; Guilaine, J.; and Decaudin, A.: Un Cas de Polychondrite Chronique Atrophiante , Bull Soc Franc Derm Syph 67:893, 1960. 36. Coste, F., et al: Polychondritis, Polyarthritis and Gougerot-Sjögren's Syndrome , Rev Rheum 28:498, 1961. 37. Dolan, D.L.; Lemmon, B.G.; and Teitelbaum, S.: Relapsing Polychondritis, Analytical Literature Review and Studies on Pathogenesis , Amer J Med 41:285-299, 1966.Crossref 38. Jackson, S.F.: " Inflammation and Diseases of Connective Tissue: A Hahnemann Symposium ," in Mills, L.C., and Moyer, J.H. (eds.): Some Biochemical Characteristics of Connective Tissue , Philadelphia: W. B. Saunders Company, pp 6-14, 1961. 39. Thomas, L.: Reversible Collapse of Rabbit Ears After Intravenous Papain, and Prevention of Recovery by Cortisone. J Exp Med 104:245, 1956.Crossref 40. McCluskey, R.T., and Thomas, L.: Removal of Cartilage Matrix, in Vivo, by Papain , J Exp Med 108:371, 1958.Crossref 41. Tsaltas, T.T.: Papain-Induced Changes in Rabbit Cartilage: Alterations in Chemical Structure of Cartilage Matrix , J Exp Med 108:507, 1958.Crossref 42. Thomas, L., et al: Comparison of the Effects of Papain and Vitamin A on Cartilage: I. The Effects in Rabbits , J Exp Med 3:705, 1960.Crossref 43. Glynn, L.E., and Holborow, E.J.: Conversion of Tissue Polysaccharides to Auto-antigens by Group A, Beta-Haemolytic Streptococci , Lancet 2:449, 1952.Crossref 44. Di Ferrante, N.: Precipitins in the Rabbit Produced by Protein Polysaccharide From Bovine Nasal Cartilage , Science 143:250, 1964.Crossref
Archives of Internal Medicine – American Medical Association
Published: Jul 1, 1967
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