Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Laboratory Tests of Hemostasis: The Relation to Hemorrhage in Liver Disease

Laboratory Tests of Hemostasis: The Relation to Hemorrhage in Liver Disease Abstract In PATIENTS with liver disease one or more abnormalities of hemostasis can frequently be demonstrated in the laboratory.1 Although it is generally believed that these abnormalities predispose to hemorrhage, it has not been clearly established that hemostatic defects are more common or more severe in bleeding than in nonbleeding patients with liver diesase. The many comprehensive reports of hemostasis in liver disease2-7 have not systematically related laboratory tests to clinical hemorrhage. Similarly, previous studies of hemostatic defects in patients with bleeding8-11 do not present comparable data on nonbleeding cirrhotics. Correlation between laboratory tests and clinical bleeding is further complicated by the difficulty in classifying minor degrees of hemorrhage. In the present report hemostatic studies were performed on a consecutive series of patients with cirrhosis admitted to a medical ward and were correlated with the incidence of major hemorrhage, defined as bleeding sufficiently severe to require transfusion. Materials References 1. Ratnoff, O.D.: Hemostatic Mechanisms in Liver Disease , Med Clin N Amer 47:721-736, 1963. 2. Harrington, W.J., et al: Bleeding Tendency in Hepatocellular and Obstructive Jaundice , Bull New Eng Med Center 12:121-128, 1950. 3. Rapaport, S.I., et al: Plasma Clotting Factors in Chronic Hepatocellular Disease , New Eng J Med 263:278-282, 1960.Crossref 4. Weaver, W.T.; Anlyan, W.G.; and Postlethwait, R.W.: Blood Coagulation Factors in Liver Disease , Surgery 50:207-212, 1961. 5. Hedenberg, L., and Korsan-Bengtsen, K.: Clotting Tests and Other Tests of the Hemostatic Mechanism in Cirrhosis of the Liver and Their Diagnostic Significance , Acta Med Scand 172:229-235, 1962.Crossref 6. Hallen, A., and Nilsson, I.M.: Coagulation Studies in Liver Disease , Thrombos Diathes Haemorrh 11:51-56, 1964. 7. Deutsch, E.: "Blood Coagulation Changes in Liver Disease" in Poppen, H. and Schaffner, F. (eds.) : Progress in Liver Disease , New York: Grune & Stratton, Inc., 1965, pp 69-83, vol 2. 8. Stefanini, M., and Petrillo E.: The Relative Importance of Plasmatic and Vascular Factors of Hemostasis in the Pathogenesis of Hemorrhagic Disease of Liver Dysfunction , Acta Med Scand 134:139-145, 1949.Crossref 9. Cowling, D.C.: Coagulation Defects in Liver Disease , J Clin Path 9:347-350, 1956.Crossref 10. Mandel, E.E., and Lazerson, J.: Thrombasthenia in Liver Disease , New Eng J Med 265: 56-61, 1961.Crossref 11. Grossi, C.E.; Rousselot, L.M.; and Panke, W.F.: Coagulation Defects in Patients With Cirrhosis of the Liver Undergoing Portasystemic Shunts , Amer J Surg 104:512-526, 1962.Crossref 12. Spector, I.; Corn, M.; and Ticktin, H.E.: Effect of Plasma Transfusions on the Prothrombin Time and Clotting Factors in Liver Disease , New Eng J Med 275:1032-1037, 1966.Crossref 13. Chalmers, T.C.; Bigelow, F.S.; and Desforges, J.F.: The Effects of Massive Gastrointestinal Hemorrhage on Hemostasis: II. Coagulation Factors , J Lab Clin Med 43:511-517, 1954. 14. Welch, C.S., et al: Treatment of Bleeding From Portal Hypertension in Patients With Cirrhosis of the Liver , New Eng J Med 24:493-502, 1956.Crossref 15. Finkbiner, K.B., et al: Coagulation Defects in Liver Disease and Response to Transfusion During Surgery , Amer J Med 26:199-213, 1957.Crossref 16. Kupfer, H., et al: Statistical Correlation of Liver Function Tests With Coagulation Factor Deficiencies in Laennec's Cirrhosis , Thrombos Diathes Haemorrh 10:317-331, 1964. 17. Davidson, C.S.: Management of Emergencies: III. Is Life Worth Living? It Depends on the Liver , New Eng J Med 274:894-896, 1966.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Laboratory Tests of Hemostasis: The Relation to Hemorrhage in Liver Disease

Spector, Israel; Corn, Milton
Archives of Internal Medicine , Volume 119 (6) – Jun 1, 1967
Download PDF
6 pages

Loading next page...
 
/lp/american-medical-association/laboratory-tests-of-hemostasis-the-relation-to-hemorrhage-in-liver-kn4gQK17t0

References (19)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1967.00290240099006
Publisher site
See Article on Publisher Site

Abstract

Abstract In PATIENTS with liver disease one or more abnormalities of hemostasis can frequently be demonstrated in the laboratory.1 Although it is generally believed that these abnormalities predispose to hemorrhage, it has not been clearly established that hemostatic defects are more common or more severe in bleeding than in nonbleeding patients with liver diesase. The many comprehensive reports of hemostasis in liver disease2-7 have not systematically related laboratory tests to clinical hemorrhage. Similarly, previous studies of hemostatic defects in patients with bleeding8-11 do not present comparable data on nonbleeding cirrhotics. Correlation between laboratory tests and clinical bleeding is further complicated by the difficulty in classifying minor degrees of hemorrhage. In the present report hemostatic studies were performed on a consecutive series of patients with cirrhosis admitted to a medical ward and were correlated with the incidence of major hemorrhage, defined as bleeding sufficiently severe to require transfusion. Materials References 1. Ratnoff, O.D.: Hemostatic Mechanisms in Liver Disease , Med Clin N Amer 47:721-736, 1963. 2. Harrington, W.J., et al: Bleeding Tendency in Hepatocellular and Obstructive Jaundice , Bull New Eng Med Center 12:121-128, 1950. 3. Rapaport, S.I., et al: Plasma Clotting Factors in Chronic Hepatocellular Disease , New Eng J Med 263:278-282, 1960.Crossref 4. Weaver, W.T.; Anlyan, W.G.; and Postlethwait, R.W.: Blood Coagulation Factors in Liver Disease , Surgery 50:207-212, 1961. 5. Hedenberg, L., and Korsan-Bengtsen, K.: Clotting Tests and Other Tests of the Hemostatic Mechanism in Cirrhosis of the Liver and Their Diagnostic Significance , Acta Med Scand 172:229-235, 1962.Crossref 6. Hallen, A., and Nilsson, I.M.: Coagulation Studies in Liver Disease , Thrombos Diathes Haemorrh 11:51-56, 1964. 7. Deutsch, E.: "Blood Coagulation Changes in Liver Disease" in Poppen, H. and Schaffner, F. (eds.) : Progress in Liver Disease , New York: Grune & Stratton, Inc., 1965, pp 69-83, vol 2. 8. Stefanini, M., and Petrillo E.: The Relative Importance of Plasmatic and Vascular Factors of Hemostasis in the Pathogenesis of Hemorrhagic Disease of Liver Dysfunction , Acta Med Scand 134:139-145, 1949.Crossref 9. Cowling, D.C.: Coagulation Defects in Liver Disease , J Clin Path 9:347-350, 1956.Crossref 10. Mandel, E.E., and Lazerson, J.: Thrombasthenia in Liver Disease , New Eng J Med 265: 56-61, 1961.Crossref 11. Grossi, C.E.; Rousselot, L.M.; and Panke, W.F.: Coagulation Defects in Patients With Cirrhosis of the Liver Undergoing Portasystemic Shunts , Amer J Surg 104:512-526, 1962.Crossref 12. Spector, I.; Corn, M.; and Ticktin, H.E.: Effect of Plasma Transfusions on the Prothrombin Time and Clotting Factors in Liver Disease , New Eng J Med 275:1032-1037, 1966.Crossref 13. Chalmers, T.C.; Bigelow, F.S.; and Desforges, J.F.: The Effects of Massive Gastrointestinal Hemorrhage on Hemostasis: II. Coagulation Factors , J Lab Clin Med 43:511-517, 1954. 14. Welch, C.S., et al: Treatment of Bleeding From Portal Hypertension in Patients With Cirrhosis of the Liver , New Eng J Med 24:493-502, 1956.Crossref 15. Finkbiner, K.B., et al: Coagulation Defects in Liver Disease and Response to Transfusion During Surgery , Amer J Med 26:199-213, 1957.Crossref 16. Kupfer, H., et al: Statistical Correlation of Liver Function Tests With Coagulation Factor Deficiencies in Laennec's Cirrhosis , Thrombos Diathes Haemorrh 10:317-331, 1964. 17. Davidson, C.S.: Management of Emergencies: III. Is Life Worth Living? It Depends on the Liver , New Eng J Med 274:894-896, 1966.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Jun 1, 1967

There are no references for this article.