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Histoplasma Endocarditis: Case Report and Review of the Literature

Histoplasma Endocarditis: Case Report and Review of the Literature Abstract HISTOPLASMOSIS as a cause of endocarditis is very uncommon. A thorough search of the literature has revealed only 16 previously reported cases. In view of the rarity of this condition, the difficulty which may be encountered in isolating the organism, and the availability of effective treatment which may arrest the disease, it was felt worthwhile to report the following case and to review the pertinent literature. Report of Case A 37-year-old white man entered the US Public Health Service Hospital, Baltimore, on July 31, 1964, because of chills, fever, and transient hemiparesis of the left side. He had had rheumatic fever at age 14, and, subsequently, heart murmurs were noted. Except for one mild episode of hemoptysis and occasional fatigue, he was asymptomatic and able to perform arduous work. Cardiac catheterization in January 1964 revealed predominant mitral stenosis with mitral insufficiency and mild aortic insufficiency. Because of minimal symptomatology, References 1. Furcolow, M.L.: Comparison of Treated and Untreated Severe Histoplasmosis: A Communicable Disease Center Cooperative Mycoses Study , JAMA 183:823-829, 1963.Crossref 2. Tenenberg, D.J.: " The Serology of Histoplasmosis ," in Sweany, H.C. (ed.): Histoplasmosis , Springfield, Ill: Charles C Thomas, Publishers, 1960, p 178. 3. Darling, S.T.: A Protozoon General Infection Producing Pseudotubercles in the Lungs and Focal Necrosis in the Liver, Spleen and Lymph Nodes , JAMA 46:1283, 1906.Crossref 4. Watson, C.J., and Riley, W.A.: A Case of Darling's Histoplasmosis Originating in Minnesota , Arch Path 1:662-667, 1926. 5. Riehl, C.: Durch pathogene sprosspilze bedingte granulome , Arch Derm Syph 148:392,1925.Crossref 6. Broders, A.C., et al: Histoplasmosis Producing Vegetative Endocarditis: Review of Literature With Report of a Case , JAMA 122:489-492, 1943.Crossref 7. Kemper, J.W., and Bloom, H.J.: Histoplasmosis: Report of a Case , J Oral Surg 2:167-172, 1944. 8. Parsons, R.J., and Zarafonetis, C.J.D.: Histoplasmosis in Man: Report of Seven Cases and a Review of 71 Cases , Arch Intern Med 75:1-23, 1945.Crossref 9. Beamer, P.R.; Reinhard, E.H.; and Goodof, I.I.: Vegetative Endocarditis Caused by Higher Bacteria and Fungi , Amer Heart J 29:99-112, 1945.Crossref 10. Fawell, W.N.; Browns, H.L.; and Ernstene, A.C.: Vegetative Endocarditis Due to Histoplasma Capsulatum: Report of a Case , Cleveland Clin Quart 18:305-309, 1951.Crossref 11. Binford, C.H.: Histoplasmosis: Tissue Reactions and Morphologic Variations of the Fungus , Amer J Clin Path 25:25-36, 1955. 12. Sulak, M.H.: Clinicopathologic Conference , US Armed Forces Med J 8:70-81, 1957. 13. Moore, M.: Morphologic Variation in Tissue of the Organisms of the Blastomycoses and of Histoplasmosis , Amer J Path 31:1049-1063, 1955. 14. Merchant, R.K., et al: Fungal Endocarditis: Review of the Literature and Report of Three Cases , Ann Intern Med 48:242-266, 1958.Crossref 15. Berman, B.: Histoplasmosis Endocarditis , Sinai Hosp J (Baltimore) 9:4-8, 1960. 16. Haust, M.D.; Wlodek, G.K.; and Parker, J.O.: Histoplasma Endocarditis , Amer J Med 32:460-466, 1962.Crossref 17. Derby, B.M.; Coolidge, K.; and Rogers, D.E.: Histoplasma capsulatum Endocarditis With Major Arterial Embolism: Report of an Apparent Recovery , Arch Intern Med 110:63-69, 1962.Crossref 18. Palmer, R.L.; Geraci, J.E.; and Thomas, B.J.: Histoplasma Endocarditis , Arch Intern Med 110:359-365, 1962.Crossref 19. Furcolow, M.L.: Tests of Immunity in Histoplasmosis , New Eng J Med 268:357-361, 1963.Crossref 20. Emmons, C.W.; Binford, C.H.; and Utz, J.P.: Medical Mycology , Philadelphia: Lea & Febiger, Publishers, 1963, p 220. 21. Crispell, K.R., et al: Addison's Disease Associated With Histoplasmosis: Report of Four Cases and Review of the Literature , Amer J Med 20:23-29, 1956.Crossref 22. Baum, G.L.; Schwartz, J.; and Wang, C.J.K.: Treatment of Experimental Histoplasmosis With Amphotericin B , Arch Intern Med 101:84-86, 1958.Crossref 23. Utz, J.P., et al: " A Report of Clinical Studies on the Use of Amphotericin in Patients With Systemic Fungal Disease ," in Antibiotics Annual 1957-1958 , New York: Medical Encyclopedia, Inc, 1958, p 65-70. 24. Yates, J.L., et al: Experience With Amphotericin in the Therapy of Histoplasmosis , Dis Chest 37:144-156, 1960.Crossref 25. Silverman, F.N., et al: Histoplasmosis , Amer J Med 19:410-459, 1955.Crossref 26. Furcolow, M.L.: The Use of Amphotericin B in Blastomycosis, Cryptococcosis and Histoplasmosis , Med Clin N Amer 47:1119-1130, 1963. 27. Butler, W.T., et al: Nephrotoxicity of Amphotericin B: Early and Late Effects in 81 Patients , Ann Intern Med 61:175-187, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Histoplasma Endocarditis: Case Report and Review of the Literature

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References (26)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1967.00290230165009
Publisher site
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Abstract

Abstract HISTOPLASMOSIS as a cause of endocarditis is very uncommon. A thorough search of the literature has revealed only 16 previously reported cases. In view of the rarity of this condition, the difficulty which may be encountered in isolating the organism, and the availability of effective treatment which may arrest the disease, it was felt worthwhile to report the following case and to review the pertinent literature. Report of Case A 37-year-old white man entered the US Public Health Service Hospital, Baltimore, on July 31, 1964, because of chills, fever, and transient hemiparesis of the left side. He had had rheumatic fever at age 14, and, subsequently, heart murmurs were noted. Except for one mild episode of hemoptysis and occasional fatigue, he was asymptomatic and able to perform arduous work. Cardiac catheterization in January 1964 revealed predominant mitral stenosis with mitral insufficiency and mild aortic insufficiency. Because of minimal symptomatology, References 1. Furcolow, M.L.: Comparison of Treated and Untreated Severe Histoplasmosis: A Communicable Disease Center Cooperative Mycoses Study , JAMA 183:823-829, 1963.Crossref 2. Tenenberg, D.J.: " The Serology of Histoplasmosis ," in Sweany, H.C. (ed.): Histoplasmosis , Springfield, Ill: Charles C Thomas, Publishers, 1960, p 178. 3. Darling, S.T.: A Protozoon General Infection Producing Pseudotubercles in the Lungs and Focal Necrosis in the Liver, Spleen and Lymph Nodes , JAMA 46:1283, 1906.Crossref 4. Watson, C.J., and Riley, W.A.: A Case of Darling's Histoplasmosis Originating in Minnesota , Arch Path 1:662-667, 1926. 5. Riehl, C.: Durch pathogene sprosspilze bedingte granulome , Arch Derm Syph 148:392,1925.Crossref 6. Broders, A.C., et al: Histoplasmosis Producing Vegetative Endocarditis: Review of Literature With Report of a Case , JAMA 122:489-492, 1943.Crossref 7. Kemper, J.W., and Bloom, H.J.: Histoplasmosis: Report of a Case , J Oral Surg 2:167-172, 1944. 8. Parsons, R.J., and Zarafonetis, C.J.D.: Histoplasmosis in Man: Report of Seven Cases and a Review of 71 Cases , Arch Intern Med 75:1-23, 1945.Crossref 9. Beamer, P.R.; Reinhard, E.H.; and Goodof, I.I.: Vegetative Endocarditis Caused by Higher Bacteria and Fungi , Amer Heart J 29:99-112, 1945.Crossref 10. Fawell, W.N.; Browns, H.L.; and Ernstene, A.C.: Vegetative Endocarditis Due to Histoplasma Capsulatum: Report of a Case , Cleveland Clin Quart 18:305-309, 1951.Crossref 11. Binford, C.H.: Histoplasmosis: Tissue Reactions and Morphologic Variations of the Fungus , Amer J Clin Path 25:25-36, 1955. 12. Sulak, M.H.: Clinicopathologic Conference , US Armed Forces Med J 8:70-81, 1957. 13. Moore, M.: Morphologic Variation in Tissue of the Organisms of the Blastomycoses and of Histoplasmosis , Amer J Path 31:1049-1063, 1955. 14. Merchant, R.K., et al: Fungal Endocarditis: Review of the Literature and Report of Three Cases , Ann Intern Med 48:242-266, 1958.Crossref 15. Berman, B.: Histoplasmosis Endocarditis , Sinai Hosp J (Baltimore) 9:4-8, 1960. 16. Haust, M.D.; Wlodek, G.K.; and Parker, J.O.: Histoplasma Endocarditis , Amer J Med 32:460-466, 1962.Crossref 17. Derby, B.M.; Coolidge, K.; and Rogers, D.E.: Histoplasma capsulatum Endocarditis With Major Arterial Embolism: Report of an Apparent Recovery , Arch Intern Med 110:63-69, 1962.Crossref 18. Palmer, R.L.; Geraci, J.E.; and Thomas, B.J.: Histoplasma Endocarditis , Arch Intern Med 110:359-365, 1962.Crossref 19. Furcolow, M.L.: Tests of Immunity in Histoplasmosis , New Eng J Med 268:357-361, 1963.Crossref 20. Emmons, C.W.; Binford, C.H.; and Utz, J.P.: Medical Mycology , Philadelphia: Lea & Febiger, Publishers, 1963, p 220. 21. Crispell, K.R., et al: Addison's Disease Associated With Histoplasmosis: Report of Four Cases and Review of the Literature , Amer J Med 20:23-29, 1956.Crossref 22. Baum, G.L.; Schwartz, J.; and Wang, C.J.K.: Treatment of Experimental Histoplasmosis With Amphotericin B , Arch Intern Med 101:84-86, 1958.Crossref 23. Utz, J.P., et al: " A Report of Clinical Studies on the Use of Amphotericin in Patients With Systemic Fungal Disease ," in Antibiotics Annual 1957-1958 , New York: Medical Encyclopedia, Inc, 1958, p 65-70. 24. Yates, J.L., et al: Experience With Amphotericin in the Therapy of Histoplasmosis , Dis Chest 37:144-156, 1960.Crossref 25. Silverman, F.N., et al: Histoplasmosis , Amer J Med 19:410-459, 1955.Crossref 26. Furcolow, M.L.: The Use of Amphotericin B in Blastomycosis, Cryptococcosis and Histoplasmosis , Med Clin N Amer 47:1119-1130, 1963. 27. Butler, W.T., et al: Nephrotoxicity of Amphotericin B: Early and Late Effects in 81 Patients , Ann Intern Med 61:175-187, 1964.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: May 1, 1967

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