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Pituitary Tumor Detected After Adrenalectomy for Cushing's Syndrome

Pituitary Tumor Detected After Adrenalectomy for Cushing's Syndrome Abstract SINCE adrenal steroids have become available for substitution therapy, total adrenalectomy constitutes the choice treatment for certain forms of Cushing's syndrome. However, this radical therapy, although curative, is followed by new problems and complications. It is the purpose of this communication to describe a patient who, following a bilateral total adrenalectomy for nontumorous Cushing syndrome, developed a pituitary tumor which secreted melanocyte stimulating hormone (MSH) and ACTH. Report of a Case At the age of 14 the patient stopped menstruating for six months following her immigration to Israel from Rumania. No treatment was given and her menstrual flow returned to normal. Three years later she noticed progressive gain of weight and increasing facial and body hair growth.She first sought medical advice in another institution in 1958 at the age of 21 years. At that time her weight was 80 kg (176 lb) and her height, 156 cm (61.6 inches). References 1. Dr. H. Kaufman of the Endocrine Laboratory of our hospital performed this estimation. 2. Dr. B. Levie, Head, Oncology Department, Beilinson Hospital, administered the radiation therapy. 3. Sulman, F.G.: Simple Test for Blood ACTH , Lancet 2:1161, 1952.Crossref 4. De Moor, P., et al: Fluorimetric Determination of Free Plasma 11-Hydroxycorticosteroids in Man , Acta Endocr 33:297, 1960. 5. Spillane, J.D.: Brunette to Blonde , Brit Med J 1:997, 1963.Crossref 6. Montgomery, D.A.D., et al: Pituitary Tumours Manifested After Adrenalectomy for Cushing's Syndrome , Lancet 2:707, 1959.Crossref 7. Nelson, D.H., et al: ACTH Producing Tumour of the Pituitary Gland , New Eng J Med 259:161, 1958.Crossref 8. Nelson, D.H.; Meakin, J.W.; and Thorn, G.W.: ACTH-Producing Pituitary Tumors Following Adrenalectomy for Cushing's Syndrome , Ann Intern Med 52:560, 1960.Crossref 9. Bayer, J.M., and Rohr, H.: Hypophysentumoren nach beidseitiger Adrenalektomie beim Hyperfunktions-Cushing , Deutsche Med Wschr 89:464, 1964.Crossref 10. Liddle, G.W.: Test of Pituitary-Adrenal Suppressibility in the Diagnosis of Cushing's Syndrome , J Clin Endocr Metab 20:1539, 1960.Crossref 11. Nelson, D.H.: Disorders of ACTH Secretion in Man , Metabolism 10:894, 1961. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Pituitary Tumor Detected After Adrenalectomy for Cushing's Syndrome

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1965.03870040100020
Publisher site
See Article on Publisher Site

Abstract

Abstract SINCE adrenal steroids have become available for substitution therapy, total adrenalectomy constitutes the choice treatment for certain forms of Cushing's syndrome. However, this radical therapy, although curative, is followed by new problems and complications. It is the purpose of this communication to describe a patient who, following a bilateral total adrenalectomy for nontumorous Cushing syndrome, developed a pituitary tumor which secreted melanocyte stimulating hormone (MSH) and ACTH. Report of a Case At the age of 14 the patient stopped menstruating for six months following her immigration to Israel from Rumania. No treatment was given and her menstrual flow returned to normal. Three years later she noticed progressive gain of weight and increasing facial and body hair growth.She first sought medical advice in another institution in 1958 at the age of 21 years. At that time her weight was 80 kg (176 lb) and her height, 156 cm (61.6 inches). References 1. Dr. H. Kaufman of the Endocrine Laboratory of our hospital performed this estimation. 2. Dr. B. Levie, Head, Oncology Department, Beilinson Hospital, administered the radiation therapy. 3. Sulman, F.G.: Simple Test for Blood ACTH , Lancet 2:1161, 1952.Crossref 4. De Moor, P., et al: Fluorimetric Determination of Free Plasma 11-Hydroxycorticosteroids in Man , Acta Endocr 33:297, 1960. 5. Spillane, J.D.: Brunette to Blonde , Brit Med J 1:997, 1963.Crossref 6. Montgomery, D.A.D., et al: Pituitary Tumours Manifested After Adrenalectomy for Cushing's Syndrome , Lancet 2:707, 1959.Crossref 7. Nelson, D.H., et al: ACTH Producing Tumour of the Pituitary Gland , New Eng J Med 259:161, 1958.Crossref 8. Nelson, D.H.; Meakin, J.W.; and Thorn, G.W.: ACTH-Producing Pituitary Tumors Following Adrenalectomy for Cushing's Syndrome , Ann Intern Med 52:560, 1960.Crossref 9. Bayer, J.M., and Rohr, H.: Hypophysentumoren nach beidseitiger Adrenalektomie beim Hyperfunktions-Cushing , Deutsche Med Wschr 89:464, 1964.Crossref 10. Liddle, G.W.: Test of Pituitary-Adrenal Suppressibility in the Diagnosis of Cushing's Syndrome , J Clin Endocr Metab 20:1539, 1960.Crossref 11. Nelson, D.H.: Disorders of ACTH Secretion in Man , Metabolism 10:894, 1961.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Oct 1, 1965

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