Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Radioactive Iodine Uptake in Hashimoto's Thyroiditis

Radioactive Iodine Uptake in Hashimoto's Thyroiditis Abstract HASHIMOTO'S thyroiditis has been the subject of much attention during the past few years, especially from the standpoint of its immunologic implications. The incidence of this condition appears to be increasing.1 Diagnosis on a clinical basis is not always easy and laboratory aid frequently must be used. In two major textbooks 2,3 and a number of recent articles,4-6 the 24-hour uptake of radioactive iodine (131I) in Hashimoto's thyroiditis has been described as either normal or increased, a characteristic which would be important in differentiating this condition from other causes of nontoxic goiter.7 Our experience differs from these findings and suggests that the 24-hour radioactive iodine (131I)uptake in Hashimoto's thyroiditis is extremely variable and nonspecific and has no diagnostic significance. Materials and Methods All patients with Hashimoto's thyroiditis diagnosed at Letterman General Hospital from January 1960 to November 1964 having undergone surgical biopsy or excision were reviewed. The pathologic diagnosis in References 1. McConahey, W. N., et al: On Increasing Occurrence of Hashimoto's Thyroiditis , J Clin Endocrinol 22:542, 1962.Crossref 2. Williams, R. H.: Text Book of Endocrinology , ed 3, Philadelphia and London: W. B. Saunders Company, 1962. 3. Werner, S. C.: Thyroid—A Fundamental and Clinical Text , ed 2, New York: Harper and Row, Publishers, Inc., 1962. 4. Doniach, D., and Hudson, R. V.: Lymphadenoid Goitre (Hashimoto's Disease) Diagnostic and Biochemical Aspects , Brit Med J 1:672, 1957.Crossref 5. Beare, R. L. B.: Lymphadenoid Goitre (Hashimoto's Disease): Clinical Pathological Study , Brit Med J 1:480, 1958.Crossref 6. El Kabir, D. J.; Doniach, D.; and Turner-Warwick, K.: Serum Content of Thyrotrophic Hormone in Human Thyroiditis , J Clin Endocrinol 23:510, 1963.Crossref 7. Doniach, D.; Hudson, R. V.; and Roitt, I. M.: Human Autoimmune Thyroiditis: Clinical Studies , Brit Med J 1:365, 1960.Crossref 8. Hashimoto, E.: Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse (Struma Lymphomatosa) , Arch F Klin Chir 97:219, 1912. 9. Marshall, S. F.; Meissner, W. A.; and Smith, D. C.: Chronic Thyroiditis , New Eng J Med 238:758, 1948.Crossref 10. Thomson, A. D.: Pathology of Hashimoto's Disease , Proc Roy Soc Med 50:950, 1957. 11. Marshall, S. F., and Meissner, W. A.: Struma Lymphomatosa (Hashimoto's Disease) , Ann Surg 141:737, 1955.Crossref 12. Wickman, W., et al: Hashimoto's Disease (Struma Lymphomatosa) , Surgery 41:313, 1957. 13. Skillern, P. G., et al: Struma Lymphomatosa: Primary Thyroid Failure With Compensatory Thyroid Enlargement , J Clin Endocrinol 16:35, 1956.Crossref 14. Murray, I. P. C., and McGirr, E. M.: Radioactive Iodine Studies in Diagnosis of Hashimoto's Thyroiditis , Brit Med J 1:838, 1960.Crossref 15. Buchanan, W. W., et al: Iodine Metabolism in Hashimoto's Thyroiditis , J Clin Endocrinol 21:806, 1961.Crossref 16. Gribetz, D.; Talbot, N. B.; and Crawford, J. D.: Goitre Due to Lymphocytic Thyroiditis (Hashimoto's Struma) , New Eng J Med 250:555, 1954.Crossref 17. McConahey, W. N., et al: Comparison of Certain Laboratory Tests in Diagnosis of Hashimoto's Thyroiditis , J Clin Endocrinol 21:879, 1961.Crossref 18. Morgans, M. E., and Trotter, W. R.: Defective Organic Binding of Iodine by Thyroid in Hashimoto's Thyroiditis , Lancet 1:553, 1957.Crossref 19. Hall, R.: Immunologic Aspects of Thyroid Function , New Eng J Med 266:1204, 1962.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Radioactive Iodine Uptake in Hashimoto's Thyroiditis

Download PDF
2 pages

Loading next page...
 
/lp/american-medical-association/radioactive-iodine-uptake-in-hashimoto-s-thyroiditis-ZJOE0W8RNz

References (21)

Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1965.03870010113013
Publisher site
See Article on Publisher Site

Abstract

Abstract HASHIMOTO'S thyroiditis has been the subject of much attention during the past few years, especially from the standpoint of its immunologic implications. The incidence of this condition appears to be increasing.1 Diagnosis on a clinical basis is not always easy and laboratory aid frequently must be used. In two major textbooks 2,3 and a number of recent articles,4-6 the 24-hour uptake of radioactive iodine (131I) in Hashimoto's thyroiditis has been described as either normal or increased, a characteristic which would be important in differentiating this condition from other causes of nontoxic goiter.7 Our experience differs from these findings and suggests that the 24-hour radioactive iodine (131I)uptake in Hashimoto's thyroiditis is extremely variable and nonspecific and has no diagnostic significance. Materials and Methods All patients with Hashimoto's thyroiditis diagnosed at Letterman General Hospital from January 1960 to November 1964 having undergone surgical biopsy or excision were reviewed. The pathologic diagnosis in References 1. McConahey, W. N., et al: On Increasing Occurrence of Hashimoto's Thyroiditis , J Clin Endocrinol 22:542, 1962.Crossref 2. Williams, R. H.: Text Book of Endocrinology , ed 3, Philadelphia and London: W. B. Saunders Company, 1962. 3. Werner, S. C.: Thyroid—A Fundamental and Clinical Text , ed 2, New York: Harper and Row, Publishers, Inc., 1962. 4. Doniach, D., and Hudson, R. V.: Lymphadenoid Goitre (Hashimoto's Disease) Diagnostic and Biochemical Aspects , Brit Med J 1:672, 1957.Crossref 5. Beare, R. L. B.: Lymphadenoid Goitre (Hashimoto's Disease): Clinical Pathological Study , Brit Med J 1:480, 1958.Crossref 6. El Kabir, D. J.; Doniach, D.; and Turner-Warwick, K.: Serum Content of Thyrotrophic Hormone in Human Thyroiditis , J Clin Endocrinol 23:510, 1963.Crossref 7. Doniach, D.; Hudson, R. V.; and Roitt, I. M.: Human Autoimmune Thyroiditis: Clinical Studies , Brit Med J 1:365, 1960.Crossref 8. Hashimoto, E.: Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse (Struma Lymphomatosa) , Arch F Klin Chir 97:219, 1912. 9. Marshall, S. F.; Meissner, W. A.; and Smith, D. C.: Chronic Thyroiditis , New Eng J Med 238:758, 1948.Crossref 10. Thomson, A. D.: Pathology of Hashimoto's Disease , Proc Roy Soc Med 50:950, 1957. 11. Marshall, S. F., and Meissner, W. A.: Struma Lymphomatosa (Hashimoto's Disease) , Ann Surg 141:737, 1955.Crossref 12. Wickman, W., et al: Hashimoto's Disease (Struma Lymphomatosa) , Surgery 41:313, 1957. 13. Skillern, P. G., et al: Struma Lymphomatosa: Primary Thyroid Failure With Compensatory Thyroid Enlargement , J Clin Endocrinol 16:35, 1956.Crossref 14. Murray, I. P. C., and McGirr, E. M.: Radioactive Iodine Studies in Diagnosis of Hashimoto's Thyroiditis , Brit Med J 1:838, 1960.Crossref 15. Buchanan, W. W., et al: Iodine Metabolism in Hashimoto's Thyroiditis , J Clin Endocrinol 21:806, 1961.Crossref 16. Gribetz, D.; Talbot, N. B.; and Crawford, J. D.: Goitre Due to Lymphocytic Thyroiditis (Hashimoto's Struma) , New Eng J Med 250:555, 1954.Crossref 17. McConahey, W. N., et al: Comparison of Certain Laboratory Tests in Diagnosis of Hashimoto's Thyroiditis , J Clin Endocrinol 21:879, 1961.Crossref 18. Morgans, M. E., and Trotter, W. R.: Defective Organic Binding of Iodine by Thyroid in Hashimoto's Thyroiditis , Lancet 1:553, 1957.Crossref 19. Hall, R.: Immunologic Aspects of Thyroid Function , New Eng J Med 266:1204, 1962.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Jul 1, 1965

There are no references for this article.