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Gaisbock's Disease: Redefinition of an Old Syndrone

Gaisbock's Disease: Redefinition of an Old Syndrone Abstract PRESENT-DAY students are usually taught that Gaisböck's syndrome is a coincidence of polycythemia vera and hypertension. However, as one follows patients with persistently elevated hematocrit values, it becomes apparent that Gaisböck may have been describing a disorder distinct from polycythemia vera. This is important since patients who have had neither an elevated total red blood cell volume, nor polycythemia vera, have been treated by phlebotomy and radioactive phosphorus. This error in diagnosis and treatment is more common than is realized. Although he recognized increase in the erythrocyte count due to plasma loss, and forms of physiologic polycythemia, Gaisböck1 regarded his polycythemia hypertonica as a true polycythemia. He regarded the presence of hypertension as the most important manifestation separating his syndrome from the Vaquez type of true polycythemia. Since hypertension is common in polycythemia vera 2 he undoubtedly included some cases in his group with polycythemia hypertonica. However, since he References 1. Gaisböck, F.: Die Polyzthämie , Ergebn Inn Med Kinderheilk 21:204, 1922. 2. Lawrence, J. H.; Berlin, N. I.; and Huff, R. L.: Nature and Treatment of Polycythemia: Studies on 263 Patients , Medicine 32:323, 1953.Crossref 3. Lawrence, J. H., and Berlin, N. I.: Relative Polycythemia—Polycythemia of Stress , Yale J Biol Med 24:498, 1952. 4. Hall, C. A.: Erythrocyte Dynamics in Liver Disease , Amer J Med 28:541, 1960.Crossref 5. VonPorat, B.: Blood Volume Determinations With Evans Blue Dye Method , Acta Med Scand 256 ( (Suppl) ):180:1-608, 1951. 6. Keith, N. M.; Rowntree, L. G.; and Geraghty, J. T.: Method for Determination of Plasma in Blood Volume , Arch Intern Med 16:547, 1915.Crossref 7. Kaung, D. T., and Peterson, R. E.: "Relative Polycythemia" or "Pseudopolycythemia," Arch Intern Med 110:456-460 ( (Oct) ) 1962.Crossref 8. Huff, R. L., and Feller, D. D.: Relation of Circulating Red Cell Volume to Body Density and Obesity , J Clin Invest 35:1, 1956.Crossref 9. Hall, C. A.: Plasma Disappearance of Radioactive Vitamin B12 in Myeloproliferative Diseases and Other Blood Disorders , Blood 18:717, 1961. 10. Bothwell, T. H., et al: Study of Erythropoiesis Using Tracer Quantities of Radioactive Iron , Brit J Haemat 2:1, 1956.Crossref 11. Lawrence, J. H., et al: Physiological Study in Peruvian Andes , Acta Med Scand 142:117, 1952.Crossref 12. Harrop, G. A., Jr.: Polycythemia , Medicine 7: 291, 1928. 13. Abildgaard, C. F.; Cornet, J. A.; and Schulman, I.: Primary Erythrocytosis , J Pediatrics 63:1072, 1964.Crossref 14. Conley, C. L., et al: Hematocrit Values in Coronary Artery Disease , Arch Intern Med 113:170, 1964.Crossref 15. Russel, R. P., and Conley, C. L.: Benign Polycythemia: Gaisböck's Syndrome , Arch Intern Med 114:734, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Gaisbock's Disease: Redefinition of an Old Syndrone

Archives of Internal Medicine , Volume 116 (1) – Jul 1, 1965

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References (17)

Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1965.03870010006002
Publisher site
See Article on Publisher Site

Abstract

Abstract PRESENT-DAY students are usually taught that Gaisböck's syndrome is a coincidence of polycythemia vera and hypertension. However, as one follows patients with persistently elevated hematocrit values, it becomes apparent that Gaisböck may have been describing a disorder distinct from polycythemia vera. This is important since patients who have had neither an elevated total red blood cell volume, nor polycythemia vera, have been treated by phlebotomy and radioactive phosphorus. This error in diagnosis and treatment is more common than is realized. Although he recognized increase in the erythrocyte count due to plasma loss, and forms of physiologic polycythemia, Gaisböck1 regarded his polycythemia hypertonica as a true polycythemia. He regarded the presence of hypertension as the most important manifestation separating his syndrome from the Vaquez type of true polycythemia. Since hypertension is common in polycythemia vera 2 he undoubtedly included some cases in his group with polycythemia hypertonica. However, since he References 1. Gaisböck, F.: Die Polyzthämie , Ergebn Inn Med Kinderheilk 21:204, 1922. 2. Lawrence, J. H.; Berlin, N. I.; and Huff, R. L.: Nature and Treatment of Polycythemia: Studies on 263 Patients , Medicine 32:323, 1953.Crossref 3. Lawrence, J. H., and Berlin, N. I.: Relative Polycythemia—Polycythemia of Stress , Yale J Biol Med 24:498, 1952. 4. Hall, C. A.: Erythrocyte Dynamics in Liver Disease , Amer J Med 28:541, 1960.Crossref 5. VonPorat, B.: Blood Volume Determinations With Evans Blue Dye Method , Acta Med Scand 256 ( (Suppl) ):180:1-608, 1951. 6. Keith, N. M.; Rowntree, L. G.; and Geraghty, J. T.: Method for Determination of Plasma in Blood Volume , Arch Intern Med 16:547, 1915.Crossref 7. Kaung, D. T., and Peterson, R. E.: "Relative Polycythemia" or "Pseudopolycythemia," Arch Intern Med 110:456-460 ( (Oct) ) 1962.Crossref 8. Huff, R. L., and Feller, D. D.: Relation of Circulating Red Cell Volume to Body Density and Obesity , J Clin Invest 35:1, 1956.Crossref 9. Hall, C. A.: Plasma Disappearance of Radioactive Vitamin B12 in Myeloproliferative Diseases and Other Blood Disorders , Blood 18:717, 1961. 10. Bothwell, T. H., et al: Study of Erythropoiesis Using Tracer Quantities of Radioactive Iron , Brit J Haemat 2:1, 1956.Crossref 11. Lawrence, J. H., et al: Physiological Study in Peruvian Andes , Acta Med Scand 142:117, 1952.Crossref 12. Harrop, G. A., Jr.: Polycythemia , Medicine 7: 291, 1928. 13. Abildgaard, C. F.; Cornet, J. A.; and Schulman, I.: Primary Erythrocytosis , J Pediatrics 63:1072, 1964.Crossref 14. Conley, C. L., et al: Hematocrit Values in Coronary Artery Disease , Arch Intern Med 113:170, 1964.Crossref 15. Russel, R. P., and Conley, C. L.: Benign Polycythemia: Gaisböck's Syndrome , Arch Intern Med 114:734, 1964.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jul 1, 1965

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