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J. Waldenström (1961)
Clinical Diagnosis and Biochemical Findings in Material of 296 Sera With M-Type, Narrow, Gamma GlobulinsActa Med Scand
O. Smithies (1959)
An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals.The Biochemical journal, 71 3
E. F. Osserman (1961)
Plasmocytic DyscrasiasAmer J Med, 31
O. Smithies (1959)
Improved Procedure for Starch Gel ElectrophoresisBiochem J, 71
E. Osserman (1958)
Natural history of multiple myeloma before radiological evidence of disease.Radiology, 71 2
P. Grabar (1959)
Immunoelectrophoretic AnalysisMeth Biochem Anal, 7
J. Fahey (1963)
HETEROGENEITY OF MYELOMA PROTEINS.The Journal of clinical investigation, 42 1
E. Osserman (1961)
The plasmocytic dyscrasias. Plasma cell myeloma and primary macroglobulinemia.The American journal of medicine, 31
Abstract THE IMAGE of a disease, including its natural history, depends in large measure on the sensitivity of diagnostic methods. Multiple myeloma was diagnosed at first only upon the occurrence of major skeletal and renal involvement. Later, when study of the marrow morphology became feasible, more subtle symptoms such as anemia could lead to the diagnosis. More recently, protein electrophoresis has added a new dimension to the study of myeloma and has made possible much earlier detection of this chronic, often slowly progressive disease. In the case reported here, paper strip electrophoresis of serum proteins led to a suspicion of myeloma six years before the diagnosis became evident by symptoms, laboratory criteria, and x-ray findings. Report of Case In November, 1956, a 61-year-old shipyard worker entered SVAH on account of painless hematuria for six months. Physical examination revealed a weight of 134 lb (60.8 kg) and tenderness in the upper right References 1. Smithies, O.: Improved Procedure for Starch Gel Electrophoresis , Biochem J 71:585, 1959. 2. Fahey, J. L.: Heterogeneity of Myeloma Proteins , J Clin Invest 42:111, 1963.Crossref 3. Grabar, P.: Immunoelectrophoretic Analysis , Meth Biochem Anal 7:1, 1959. 4. Osserman, E. F.: Natural History of Multiple Myeloma Before Radiological Evidence of Disease , Radiology 71:157-174, 1958.Crossref 5. Osserman, E. F.: Plasmocytic Dyscrasias , Amer J Med 31:671-675, 1961.Crossref 6. Waldenström, J.: Clinical Diagnosis and Biochemical Findings in Material of 296 Sera With M-Type, Narrow, Gamma Globulins , Acta Med Scand , (suppl 367) , p 110, 1961.
Archives of Internal Medicine – American Medical Association
Published: Jan 1, 1965
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