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Evolution of Multiple Myeloma

Evolution of Multiple Myeloma Abstract THE IMAGE of a disease, including its natural history, depends in large measure on the sensitivity of diagnostic methods. Multiple myeloma was diagnosed at first only upon the occurrence of major skeletal and renal involvement. Later, when study of the marrow morphology became feasible, more subtle symptoms such as anemia could lead to the diagnosis. More recently, protein electrophoresis has added a new dimension to the study of myeloma and has made possible much earlier detection of this chronic, often slowly progressive disease. In the case reported here, paper strip electrophoresis of serum proteins led to a suspicion of myeloma six years before the diagnosis became evident by symptoms, laboratory criteria, and x-ray findings. Report of Case In November, 1956, a 61-year-old shipyard worker entered SVAH on account of painless hematuria for six months. Physical examination revealed a weight of 134 lb (60.8 kg) and tenderness in the upper right References 1. Smithies, O.: Improved Procedure for Starch Gel Electrophoresis , Biochem J 71:585, 1959. 2. Fahey, J. L.: Heterogeneity of Myeloma Proteins , J Clin Invest 42:111, 1963.Crossref 3. Grabar, P.: Immunoelectrophoretic Analysis , Meth Biochem Anal 7:1, 1959. 4. Osserman, E. F.: Natural History of Multiple Myeloma Before Radiological Evidence of Disease , Radiology 71:157-174, 1958.Crossref 5. Osserman, E. F.: Plasmocytic Dyscrasias , Amer J Med 31:671-675, 1961.Crossref 6. Waldenström, J.: Clinical Diagnosis and Biochemical Findings in Material of 296 Sera With M-Type, Narrow, Gamma Globulins , Acta Med Scand , (suppl 367) , p 110, 1961. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Evolution of Multiple Myeloma

Archives of Internal Medicine , Volume 115 (1) – Jan 1, 1965

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1965.03860130092016
Publisher site
See Article on Publisher Site

Abstract

Abstract THE IMAGE of a disease, including its natural history, depends in large measure on the sensitivity of diagnostic methods. Multiple myeloma was diagnosed at first only upon the occurrence of major skeletal and renal involvement. Later, when study of the marrow morphology became feasible, more subtle symptoms such as anemia could lead to the diagnosis. More recently, protein electrophoresis has added a new dimension to the study of myeloma and has made possible much earlier detection of this chronic, often slowly progressive disease. In the case reported here, paper strip electrophoresis of serum proteins led to a suspicion of myeloma six years before the diagnosis became evident by symptoms, laboratory criteria, and x-ray findings. Report of Case In November, 1956, a 61-year-old shipyard worker entered SVAH on account of painless hematuria for six months. Physical examination revealed a weight of 134 lb (60.8 kg) and tenderness in the upper right References 1. Smithies, O.: Improved Procedure for Starch Gel Electrophoresis , Biochem J 71:585, 1959. 2. Fahey, J. L.: Heterogeneity of Myeloma Proteins , J Clin Invest 42:111, 1963.Crossref 3. Grabar, P.: Immunoelectrophoretic Analysis , Meth Biochem Anal 7:1, 1959. 4. Osserman, E. F.: Natural History of Multiple Myeloma Before Radiological Evidence of Disease , Radiology 71:157-174, 1958.Crossref 5. Osserman, E. F.: Plasmocytic Dyscrasias , Amer J Med 31:671-675, 1961.Crossref 6. Waldenström, J.: Clinical Diagnosis and Biochemical Findings in Material of 296 Sera With M-Type, Narrow, Gamma Globulins , Acta Med Scand , (suppl 367) , p 110, 1961.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1965

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