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Idiopathic Pulmonary Hemosiderosis Without Anemia: Report of Two Cases

Idiopathic Pulmonary Hemosiderosis Without Anemia: Report of Two Cases Abstract Idiopathic pulmonary hemosiderosis (IPH) has generally been associated with a persistent hypochromic anemia.1 During the protracted course of the disease, particularly during clinical remission, the hematologic abnormalities may be minimal.2 A complete restoration of normal hemoglobin levels is unusual, and most observers have alluded to a chronic anemic state during periods of clinical remission.3 The classic case comes to the attention of a physician because of symptoms related directly or indirectly to anemia. We have had the opportunity to study two cases of adult pulmonary hemosiderosis in which there was no evidence of anemia over a period of years despite a persistent pulmonary infiltration. It is the purpose of this report to compare the clinical and pathologic observations in these two patients to those made previously in IPH. Report of Cases Case 1. —A 29-year-old Negro male was referred to the hospital because of bilateral pulmonary infiltrates References 1. Ognibene, A. J., and Johnson, D. E.: Idiopathic Pulmonary Hemosiderosis in Adults: Report of Case and Review of Literature , Arch Intern Med 111:503-510, 1963.Crossref 2. Soergel, K. H., and Sommers, S. C.: Idiopathic Pulmonary Hemosiderosis and Related Syndromes , Amer J Med 32:499-511, 1962.Crossref 3. Chatgidakis, C. B.: Primary Pulmonary Hemosiderosis (Ceelen's Disease) , S Afr J Lab Clin Med 1:166-170, 1955. 4. Ognibene, A. J., and Kito, W. R.: Rheumatoid Disease With Unusual Pulmonary Manifestations: Pulmonary Hemosiderosis, Fibrosis, Concretions, to be published. 5. Soergel, K. H., and Sommers, S. C.: Alveolar Epithelial Lesion of Idiopathic Pulmonary Hemosiderosis , Amer Rev Resp Dis 85:540-552, 1962. 6. Karlish, A. J.: Idiopathic Pulmonary Hemosiderosis With Unusual Features , Proc Roy Soc Med 55:223-225, 1962. 7. Hamilton, H. E.; Sheets, R. F.; and Evans, R. C.: Erythrocyte Destruction in Lungs as Major Cause of Anemia in Primary Pulmonary Hemosiderosis , Proc Cent Soc Clin Res 33:44, 1960. 8. Apt, L.; Pollycove, M.; and Ross, J. F.: Idiopathic Pulmonary Hemosiderosis: Study of Anemia and Iron Distribution Using Radioiron and Radiochromium , J Clin Invest 36:1150-1159, 1957.Crossref 9. Heiner, D. C.; Sear, J. W.; and Kniker, W. T.: Multiple Precipitins to Cow's Milk in Chronic Respiratory Disease , Amer J Dis Child 103:634-654, 1962.Crossref 10. Milgrom, F., et al: Studies on Rheumatoid and Related Serum Factors: II. Relation of Anti-Human and Anti-Rabbit Gamma Globulin Factors in Rheumatoid Arthritis Serums , JAMA 181:476-484, 1962.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Idiopathic Pulmonary Hemosiderosis Without Anemia: Report of Two Cases

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1964.03860100072006
Publisher site
See Article on Publisher Site

Abstract

Abstract Idiopathic pulmonary hemosiderosis (IPH) has generally been associated with a persistent hypochromic anemia.1 During the protracted course of the disease, particularly during clinical remission, the hematologic abnormalities may be minimal.2 A complete restoration of normal hemoglobin levels is unusual, and most observers have alluded to a chronic anemic state during periods of clinical remission.3 The classic case comes to the attention of a physician because of symptoms related directly or indirectly to anemia. We have had the opportunity to study two cases of adult pulmonary hemosiderosis in which there was no evidence of anemia over a period of years despite a persistent pulmonary infiltration. It is the purpose of this report to compare the clinical and pathologic observations in these two patients to those made previously in IPH. Report of Cases Case 1. —A 29-year-old Negro male was referred to the hospital because of bilateral pulmonary infiltrates References 1. Ognibene, A. J., and Johnson, D. E.: Idiopathic Pulmonary Hemosiderosis in Adults: Report of Case and Review of Literature , Arch Intern Med 111:503-510, 1963.Crossref 2. Soergel, K. H., and Sommers, S. C.: Idiopathic Pulmonary Hemosiderosis and Related Syndromes , Amer J Med 32:499-511, 1962.Crossref 3. Chatgidakis, C. B.: Primary Pulmonary Hemosiderosis (Ceelen's Disease) , S Afr J Lab Clin Med 1:166-170, 1955. 4. Ognibene, A. J., and Kito, W. R.: Rheumatoid Disease With Unusual Pulmonary Manifestations: Pulmonary Hemosiderosis, Fibrosis, Concretions, to be published. 5. Soergel, K. H., and Sommers, S. C.: Alveolar Epithelial Lesion of Idiopathic Pulmonary Hemosiderosis , Amer Rev Resp Dis 85:540-552, 1962. 6. Karlish, A. J.: Idiopathic Pulmonary Hemosiderosis With Unusual Features , Proc Roy Soc Med 55:223-225, 1962. 7. Hamilton, H. E.; Sheets, R. F.; and Evans, R. C.: Erythrocyte Destruction in Lungs as Major Cause of Anemia in Primary Pulmonary Hemosiderosis , Proc Cent Soc Clin Res 33:44, 1960. 8. Apt, L.; Pollycove, M.; and Ross, J. F.: Idiopathic Pulmonary Hemosiderosis: Study of Anemia and Iron Distribution Using Radioiron and Radiochromium , J Clin Invest 36:1150-1159, 1957.Crossref 9. Heiner, D. C.; Sear, J. W.; and Kniker, W. T.: Multiple Precipitins to Cow's Milk in Chronic Respiratory Disease , Amer J Dis Child 103:634-654, 1962.Crossref 10. Milgrom, F., et al: Studies on Rheumatoid and Related Serum Factors: II. Relation of Anti-Human and Anti-Rabbit Gamma Globulin Factors in Rheumatoid Arthritis Serums , JAMA 181:476-484, 1962.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Oct 1, 1964

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