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Splenomegaly With Rare Morphologically Distinct Histiocyte: A Syndrome

Splenomegaly With Rare Morphologically Distinct Histiocyte: A Syndrome Abstract Within recent years reports have appeared concerning an unidentified reticuloendothelial cell in the bone marrow and spleen of adults.1-3 This cell has varied in size from 15μ to 60μ. Its outstanding feature has been the presence of a deep-blue-staining granular material in the cytoplasm, as demonstrated with the Wright or Giemsa stain. The purpose of this communication is to present an additional patient in whom this histiocyte was found, to describe results of histochemical analysis of the cell, and to compare the findings of lipid analysis of a spleen infiltrated with this cell with those in a normal spleen. Data concerning mucopolysaccharide metabolism in this patient will be described, and the relationship of this case to cases in similar reports will be discussed. Report of a Case A 60-year-old white woman was seen at the Mayo Clinic in February, 1963. She came primarily because of fatigue, splenomegaly, gallbladder trouble, References 1. Malinin, T. I.: Unidentified Reticuloendothelial Cell Storage Disease , Blood 17:675-686 ( (June) ) 1961. 2. Marshall, A. H. E., and Adams, C. W. M.: Unusual Form of Lipidosis Associated With Thrombocytopenia and Angiomata of Spleen , J Path Bact 76:159-164 ( (July) ) 1958.Crossref 3. Sawitsky, A.; Hyman, G. A.; and Hyman, J. B.: Unidentified Reticuloendothelial Cell in Bone Marrow and Spleen: Report of Two Cases With Histochemical Studies , Blood 9:977-985 ( (Oct) ) 1954. 4. Di Ferrante, N., and Rich, C.: Mucopolysaccharide of Normal Human Urine , Clin Chim Acta 1:519-524 ( (Nov-Dec) ) 1956.Crossref 5. Terry, R. D.; Sperry, W. M.; and Brodoff, B.: Adult Lipidosis Resembling Niemann-Pick's Disease , Amer J Path 30:263-285 ( (March-April) ) 1954. 6. Saltzstein, S. L.: Phospholipid Accumulation in Histiocytes of Splenic Pulp Associated With Thrombocytopenic Purpura , Blood 18:73-88 ( (July) ) 1961. 7. Hill, J. M.; Speer, R. J.; and Gedikoglu, H. Secondary Lipidosis of Spleen Associated With Thrombocytopenia and Other Blood Dyscrasias Treated With Steroids , Amer J Clin Path 39:607-615 ( (June) ) 1963. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Splenomegaly With Rare Morphologically Distinct Histiocyte: A Syndrome

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1964.03860080101010
Publisher site
See Article on Publisher Site

Abstract

Abstract Within recent years reports have appeared concerning an unidentified reticuloendothelial cell in the bone marrow and spleen of adults.1-3 This cell has varied in size from 15μ to 60μ. Its outstanding feature has been the presence of a deep-blue-staining granular material in the cytoplasm, as demonstrated with the Wright or Giemsa stain. The purpose of this communication is to present an additional patient in whom this histiocyte was found, to describe results of histochemical analysis of the cell, and to compare the findings of lipid analysis of a spleen infiltrated with this cell with those in a normal spleen. Data concerning mucopolysaccharide metabolism in this patient will be described, and the relationship of this case to cases in similar reports will be discussed. Report of a Case A 60-year-old white woman was seen at the Mayo Clinic in February, 1963. She came primarily because of fatigue, splenomegaly, gallbladder trouble, References 1. Malinin, T. I.: Unidentified Reticuloendothelial Cell Storage Disease , Blood 17:675-686 ( (June) ) 1961. 2. Marshall, A. H. E., and Adams, C. W. M.: Unusual Form of Lipidosis Associated With Thrombocytopenia and Angiomata of Spleen , J Path Bact 76:159-164 ( (July) ) 1958.Crossref 3. Sawitsky, A.; Hyman, G. A.; and Hyman, J. B.: Unidentified Reticuloendothelial Cell in Bone Marrow and Spleen: Report of Two Cases With Histochemical Studies , Blood 9:977-985 ( (Oct) ) 1954. 4. Di Ferrante, N., and Rich, C.: Mucopolysaccharide of Normal Human Urine , Clin Chim Acta 1:519-524 ( (Nov-Dec) ) 1956.Crossref 5. Terry, R. D.; Sperry, W. M.; and Brodoff, B.: Adult Lipidosis Resembling Niemann-Pick's Disease , Amer J Path 30:263-285 ( (March-April) ) 1954. 6. Saltzstein, S. L.: Phospholipid Accumulation in Histiocytes of Splenic Pulp Associated With Thrombocytopenic Purpura , Blood 18:73-88 ( (July) ) 1961. 7. Hill, J. M.; Speer, R. J.; and Gedikoglu, H. Secondary Lipidosis of Spleen Associated With Thrombocytopenia and Other Blood Dyscrasias Treated With Steroids , Amer J Clin Path 39:607-615 ( (June) ) 1963.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1964

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