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Renal Glycosuria In Pre-Existing Diabetes

Renal Glycosuria In Pre-Existing Diabetes Abstract Introduction The clinical course of diabetes mellitus may be characterized by extreme lability. In some patients the mechanism responsible for this lability is unknown, but in other cases the "brittle" diabetes is associated with excess insulin administration,1-4 pregnancy,5 or hyperthyroidism.6That pre-existing diabetes mellitus may be made labile by the development of renal glycosuria has not been reported previously. Four such patients are described in this report. Materials and Methods Four young diabetic males were found to have renal glycosuria during hospitalization at the University of Utah Affiliated Hospitals from 1957 to 1961 by means of simultaneous blood and urine glucose determinations made on several occasions in each case as follows: The patient was asked to empty the bladder. Thirty minutes later he again voided, and a venous blood sample was obtained. The glucose concentration in the 30-minute urine sample was compared to the glucose level in References 1. Dr. John Read provided the opportunity to study this patient. 2. Joslin, E. P.; Gray, H.; and Root, H. E.: Insulin in Hospital and Home , J Metab Res 2:651-659, 1924. 3. Wilder, R. M., et al: Clinical Observations on Insulin , J Metab Res 2:701-728, 1924. 4. Perkoff, G. T., and Tyler, F. H.: Paradoxical Hyperglycemia in Diabetic Patients Treated With Insulin , Metabolism 3:110-117, 1954. 5. Somogyi, M.: Diabetogenic Effect of Hyperinsulinism , Amer J Med 26:192-198, 1959.Crossref 6. Perkoff, G. T., and Tyler, F. H.: Renal Glycosuria in Pregnant Diabetic Patients , AMA Arch Intern Med 97:758-761, 1956.Crossref 7. Abt, A. F.: Hyperthyroidism and Diabetes , Metabolism 11:202-212, 1962. 8. Nelson, N.: Photometric Adaptation of Somogyi Method for Determination of Glucose , J Biol Chem 153:375-380, 1944. 9. Somogyi, M.: Rapid Method for Estimation of Urine Sugar , J Lab Clin Med 26:1220-1223, 1940. 10. Phillips, R. A., in Peters, S. P., and Van Slyke, D. D.: Quantitative Clinical Chemistry , Army edition, Baltimore: Williams & Williams Company, 1943, chap V: "Methods," p 2. 11. Smith, H. W.: The Kidney: Structure and Function in Health and Disease , London: Oxford University Press, 1951, p 91. 12. Nugent, C. A., and Stowell, W.: Localization of Kidney for Renal Biopsy , J Urol 82:193-196, 1959. 13. Yalow, R. S., and Berson, S. A.: Immunologic Aspects of Insulin , Amer J Med 31:882-891, 1961.Crossref 14. Curran, J. A., and Mills, C. A.: Report of Case of Renal Diabetes Associated With Diabetes Mellitus , J Lab Clin Med 13:646-647, 1928. 15. Voigt, C.: Case of Diabetes With Renal Glycosuria , Lancet 2:916-917, 1927.Crossref 16. Lozinski, E., and Frohlich, L. I.: Coincidental Diabetes Mellitus and Renal Glycosuria , Canad Med Ass J 36:598-599, 1937. 17. Robertson, J. A., and Gray, C. H.: Mechanism of Lowered Renal Threshold for Glucose in Diabetes , Lancet 2:12-15, 1953.Crossref 18. Drucker, W. D.; Fitch, R. F.; and Gaston, J. H.: Diabetes Mellitus and Preexisting Renal Glucosuria , Arch Intern Med 110:199-204, 1962.Crossref 19. Siperstein, M. D.: Inter-Relationships of Glucose and Lipid Metabolism , Amer J Med 26:685-702, 1959.Crossref 20. Welsh, G. W., and Sims, E. A. H.: Mechanisms of Renal Glycosuria in Pregnancy , Diabetes 9:363-369, 1960. 21. Joslin, E. T., et al: Treatment of Diabetes Mellitus , ed 10, Philadelphia: Lea & Febiger, Publishers, 1959, p 720. 22. Ackerman, I. P.; Fajans, S. S.; and Conn, J. W.: Development of Diabetes Mellitus in Patients With Non-Diabetic Glycosuria , Clin Res 6: 251, 1958. 23. Leaf, A.: "Syndrome of Osteomalacia, Renal Glycosuria, Amino Aciduria, and Hyperphosphaturia (Fanconi Syndrome)," in Metabolic Basis of Inherited Disease , New York: McGraw-Hill Book Company, Inc., 1960, p 1222. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Renal Glycosuria In Pre-Existing Diabetes

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References (23)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1964.00280110029005
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Abstract

Abstract Introduction The clinical course of diabetes mellitus may be characterized by extreme lability. In some patients the mechanism responsible for this lability is unknown, but in other cases the "brittle" diabetes is associated with excess insulin administration,1-4 pregnancy,5 or hyperthyroidism.6That pre-existing diabetes mellitus may be made labile by the development of renal glycosuria has not been reported previously. Four such patients are described in this report. Materials and Methods Four young diabetic males were found to have renal glycosuria during hospitalization at the University of Utah Affiliated Hospitals from 1957 to 1961 by means of simultaneous blood and urine glucose determinations made on several occasions in each case as follows: The patient was asked to empty the bladder. Thirty minutes later he again voided, and a venous blood sample was obtained. The glucose concentration in the 30-minute urine sample was compared to the glucose level in References 1. Dr. John Read provided the opportunity to study this patient. 2. Joslin, E. P.; Gray, H.; and Root, H. E.: Insulin in Hospital and Home , J Metab Res 2:651-659, 1924. 3. Wilder, R. M., et al: Clinical Observations on Insulin , J Metab Res 2:701-728, 1924. 4. Perkoff, G. T., and Tyler, F. H.: Paradoxical Hyperglycemia in Diabetic Patients Treated With Insulin , Metabolism 3:110-117, 1954. 5. Somogyi, M.: Diabetogenic Effect of Hyperinsulinism , Amer J Med 26:192-198, 1959.Crossref 6. Perkoff, G. T., and Tyler, F. H.: Renal Glycosuria in Pregnant Diabetic Patients , AMA Arch Intern Med 97:758-761, 1956.Crossref 7. Abt, A. F.: Hyperthyroidism and Diabetes , Metabolism 11:202-212, 1962. 8. Nelson, N.: Photometric Adaptation of Somogyi Method for Determination of Glucose , J Biol Chem 153:375-380, 1944. 9. Somogyi, M.: Rapid Method for Estimation of Urine Sugar , J Lab Clin Med 26:1220-1223, 1940. 10. Phillips, R. A., in Peters, S. P., and Van Slyke, D. D.: Quantitative Clinical Chemistry , Army edition, Baltimore: Williams & Williams Company, 1943, chap V: "Methods," p 2. 11. Smith, H. W.: The Kidney: Structure and Function in Health and Disease , London: Oxford University Press, 1951, p 91. 12. Nugent, C. A., and Stowell, W.: Localization of Kidney for Renal Biopsy , J Urol 82:193-196, 1959. 13. Yalow, R. S., and Berson, S. A.: Immunologic Aspects of Insulin , Amer J Med 31:882-891, 1961.Crossref 14. Curran, J. A., and Mills, C. A.: Report of Case of Renal Diabetes Associated With Diabetes Mellitus , J Lab Clin Med 13:646-647, 1928. 15. Voigt, C.: Case of Diabetes With Renal Glycosuria , Lancet 2:916-917, 1927.Crossref 16. Lozinski, E., and Frohlich, L. I.: Coincidental Diabetes Mellitus and Renal Glycosuria , Canad Med Ass J 36:598-599, 1937. 17. Robertson, J. A., and Gray, C. H.: Mechanism of Lowered Renal Threshold for Glucose in Diabetes , Lancet 2:12-15, 1953.Crossref 18. Drucker, W. D.; Fitch, R. F.; and Gaston, J. H.: Diabetes Mellitus and Preexisting Renal Glucosuria , Arch Intern Med 110:199-204, 1962.Crossref 19. Siperstein, M. D.: Inter-Relationships of Glucose and Lipid Metabolism , Amer J Med 26:685-702, 1959.Crossref 20. Welsh, G. W., and Sims, E. A. H.: Mechanisms of Renal Glycosuria in Pregnancy , Diabetes 9:363-369, 1960. 21. Joslin, E. T., et al: Treatment of Diabetes Mellitus , ed 10, Philadelphia: Lea & Febiger, Publishers, 1959, p 720. 22. Ackerman, I. P.; Fajans, S. S.; and Conn, J. W.: Development of Diabetes Mellitus in Patients With Non-Diabetic Glycosuria , Clin Res 6: 251, 1958. 23. Leaf, A.: "Syndrome of Osteomalacia, Renal Glycosuria, Amino Aciduria, and Hyperphosphaturia (Fanconi Syndrome)," in Metabolic Basis of Inherited Disease , New York: McGraw-Hill Book Company, Inc., 1960, p 1222.

Journal

Archives of Internal Medicine – American Medical Association

Published: May 1, 1964

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