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Anicteric Hepatitis in Korea: I. Clinical and Laboratory Studies

Anicteric Hepatitis in Korea: I. Clinical and Laboratory Studies Abstract The incidence and clinical and laboratory features, as well as the structural alterations, of anicteric hepatitis are not established. Evidence for its existence is based on sporadic cases occurring simultaneously with icteric viral hepatitis in circumscribed outbreaks. As a result of a mass serum enzyme survey originally designed to detect pre-icteric cases of viral hepatitis in an endemic population, 32 cases were uncovered on the basis of significantly abnormal serum activities of glutamic pyruvic transaminase (SGPT). These cases were hospitalized for intensive clinical, laboratory, and histopathologic study. The present report summarizes the clinical and laboratory findings in this series of patients. Their pathologic findings, described in the following paper,1 serve in addition to indicate that this group of patients represented a disease entity of chronic, active hepatitis. Materials and Methods SGPT activity was determined in 1,906 soldiers of the Republic of Korea Army, who had recently passed a physical References 1. Chung, W. K., et al: Anicteric Hepatitis in Korea: II. Serial Histologic Studies , Arch Intern Med , this issue p 535-542. 2. Sigma Technical Bulletin , No. (505) , revised 15, St. Louis: Sigma Chemical Company, 1961. 3. Sigma Technical Bulletin , No. (104) , revised St. Louis: Sigma Chemical Company, 1960. 4. Sigma Technical Bulletin , No. (175) , revised, St. Louis: Sigma Chemical Company, 1961. 5. Heplen, O. E.: Manual of Clinical Laboratory Methods , Springfield, Ill: Charles C Thomas, Publisher, 1953. 6. Wolfson, W. O., et al: Studies in Serum Proteins: 1. Rapid Procedure for Estimation of Total Protein, True Albumin, Total Globulin, Beta- Globulin and Gamma-Globulin in 1.0 M1 Serum , Amer J Clin Path 18:723-730, 1948. 7. Maclagan, N. F.: Thymol Turbidity Test: New Indicator of Liver Dysfunction , Brit J Exp Path 25:234-241, 1944. 8. Hanger, F. M.: Serological Differentiation of Obstructive From Hepatogenous Jaundice by Flocculation of Cephalin Cholesterol Emulsion , J Clin Invest 18:261-269, 1939.Crossref 9. Spinco Technical Bulletin OIR-I, No. 6027A, Palto Alto, Calif: Spinco Division, Beckman Instruments, Inc., 1960. 10. Rosenthal, S. M., and White, E. C.: Clinical Application of the Bromsulphalein Test for Hepatic Function , JAMA 84:1112-1114, 1925.Crossref 11. Chung, W. K.: Studies on Clinical Laboratory and Histological Findings of Liver Biopsy in Epidemic Viral Hepatitis: Part I. Clinical and Laboratory Findings in Acute Phase , Seoul J Med 1:117-140, 1960. 12. Denber, H. C. B., and Leibowitz, S.: Acute Anicteric Virus Hepatitis: Report of 30 Cases , JAMA 149:546-549, 1952.Crossref 13. Morrison, L. M., et al: Epidemic Nonicteric Viral Hepatitis , Amer J Gastroent 32:467-476, 1959. 14. Schön, H.; Englisch, B.; and Wüst, H.: Serum fermentuntersuchungen bei einer Hepatitisepidemie , Deutsch Med Wschr 85:265-267, 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Anicteric Hepatitis in Korea: I. Clinical and Laboratory Studies

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1964.00280100034007
Publisher site
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Abstract

Abstract The incidence and clinical and laboratory features, as well as the structural alterations, of anicteric hepatitis are not established. Evidence for its existence is based on sporadic cases occurring simultaneously with icteric viral hepatitis in circumscribed outbreaks. As a result of a mass serum enzyme survey originally designed to detect pre-icteric cases of viral hepatitis in an endemic population, 32 cases were uncovered on the basis of significantly abnormal serum activities of glutamic pyruvic transaminase (SGPT). These cases were hospitalized for intensive clinical, laboratory, and histopathologic study. The present report summarizes the clinical and laboratory findings in this series of patients. Their pathologic findings, described in the following paper,1 serve in addition to indicate that this group of patients represented a disease entity of chronic, active hepatitis. Materials and Methods SGPT activity was determined in 1,906 soldiers of the Republic of Korea Army, who had recently passed a physical References 1. Chung, W. K., et al: Anicteric Hepatitis in Korea: II. Serial Histologic Studies , Arch Intern Med , this issue p 535-542. 2. Sigma Technical Bulletin , No. (505) , revised 15, St. Louis: Sigma Chemical Company, 1961. 3. Sigma Technical Bulletin , No. (104) , revised St. Louis: Sigma Chemical Company, 1960. 4. Sigma Technical Bulletin , No. (175) , revised, St. Louis: Sigma Chemical Company, 1961. 5. Heplen, O. E.: Manual of Clinical Laboratory Methods , Springfield, Ill: Charles C Thomas, Publisher, 1953. 6. Wolfson, W. O., et al: Studies in Serum Proteins: 1. Rapid Procedure for Estimation of Total Protein, True Albumin, Total Globulin, Beta- Globulin and Gamma-Globulin in 1.0 M1 Serum , Amer J Clin Path 18:723-730, 1948. 7. Maclagan, N. F.: Thymol Turbidity Test: New Indicator of Liver Dysfunction , Brit J Exp Path 25:234-241, 1944. 8. Hanger, F. M.: Serological Differentiation of Obstructive From Hepatogenous Jaundice by Flocculation of Cephalin Cholesterol Emulsion , J Clin Invest 18:261-269, 1939.Crossref 9. Spinco Technical Bulletin OIR-I, No. 6027A, Palto Alto, Calif: Spinco Division, Beckman Instruments, Inc., 1960. 10. Rosenthal, S. M., and White, E. C.: Clinical Application of the Bromsulphalein Test for Hepatic Function , JAMA 84:1112-1114, 1925.Crossref 11. Chung, W. K.: Studies on Clinical Laboratory and Histological Findings of Liver Biopsy in Epidemic Viral Hepatitis: Part I. Clinical and Laboratory Findings in Acute Phase , Seoul J Med 1:117-140, 1960. 12. Denber, H. C. B., and Leibowitz, S.: Acute Anicteric Virus Hepatitis: Report of 30 Cases , JAMA 149:546-549, 1952.Crossref 13. Morrison, L. M., et al: Epidemic Nonicteric Viral Hepatitis , Amer J Gastroent 32:467-476, 1959. 14. Schön, H.; Englisch, B.; and Wüst, H.: Serum fermentuntersuchungen bei einer Hepatitisepidemie , Deutsch Med Wschr 85:265-267, 1960.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Apr 1, 1964

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