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Clinical and Laboratory Studies of Sodium Diphenicillin: I. Activity Against Gram-Positive Cocci in Vitro and Absorption From Gastrointestinal Tract of Human Subjects

Clinical and Laboratory Studies of Sodium Diphenicillin: I. Activity Against Gram-Positive Cocci... Abstract Introduction The purpose of this paper is to present data on the antibacterial activity of a new penicillinase-resistant penicillin and its absorption from the gastrointestinal tract. The drug is sodium diphenicillin (sodium 2-biphenylylpenicillin)1 and is manufactured from penicillanic acid. Material and Methods Sodium diphenicillin was supplied to us by Smith Kline & French Laboratories as a white powder and labeled SK&F 12141. It is also known as Ancillin. It is highly soluble in water and is stable in high concentration in aqueous solution for at least ten days at 4 C. Its structural formula has been reported.1 Bacteria Tested.— The group included 114 strains of mannitol-positive Staphylococcus aureus recovered from various clinical lesions in patients in the Cincinnati General and the Longview State Hospitals. Two strains (Nos. 48 and 49) were methicillin-resistant staphylococci kindly sent us by Dr. Patricia Jevons of the Staphylococcus Reference Laboratory, London, England. Strains References 1. Lyophilized at Fort Lewis, Wash, in June, 1945, and reconstituted in November, 1961. 2. Gourevitch, A.; Holdrege, C. T.; Hunt, G. A.; Minor, W. F.; Flanigan, C. C.; Cheney, L. C.; and Lein, J.: Preparation and Properties of 2-Biphenylyl Penicillin , Antibiot Chemother (NY) 12:318-324 ( (May) ) 1962. 3. Hamburger, M.; Carleton, J.; Walker, W. F.; and Clark, K. L.: A Study of Experimental Staphylococcal Endocarditis in Dogs: II. Penicillin-Sensitive Mutants Arising from Penicillin-Resistant Staphylococcus Aureus During the Course of Experimental Canine Endocarditis , AMA Arch Intern Med 105:668-674 ( (May) ) 1960.Crossref 4. Knox, R.: A New Penicillin (BRL 1241) Active Against Penicillin-Resistant Staphylococci , Brit Med J 2:690-693 ( (Sept) ) 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Clinical and Laboratory Studies of Sodium Diphenicillin: I. Activity Against Gram-Positive Cocci in Vitro and Absorption From Gastrointestinal Tract of Human Subjects

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1963.03620300070012
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction The purpose of this paper is to present data on the antibacterial activity of a new penicillinase-resistant penicillin and its absorption from the gastrointestinal tract. The drug is sodium diphenicillin (sodium 2-biphenylylpenicillin)1 and is manufactured from penicillanic acid. Material and Methods Sodium diphenicillin was supplied to us by Smith Kline & French Laboratories as a white powder and labeled SK&F 12141. It is also known as Ancillin. It is highly soluble in water and is stable in high concentration in aqueous solution for at least ten days at 4 C. Its structural formula has been reported.1 Bacteria Tested.— The group included 114 strains of mannitol-positive Staphylococcus aureus recovered from various clinical lesions in patients in the Cincinnati General and the Longview State Hospitals. Two strains (Nos. 48 and 49) were methicillin-resistant staphylococci kindly sent us by Dr. Patricia Jevons of the Staphylococcus Reference Laboratory, London, England. Strains References 1. Lyophilized at Fort Lewis, Wash, in June, 1945, and reconstituted in November, 1961. 2. Gourevitch, A.; Holdrege, C. T.; Hunt, G. A.; Minor, W. F.; Flanigan, C. C.; Cheney, L. C.; and Lein, J.: Preparation and Properties of 2-Biphenylyl Penicillin , Antibiot Chemother (NY) 12:318-324 ( (May) ) 1962. 3. Hamburger, M.; Carleton, J.; Walker, W. F.; and Clark, K. L.: A Study of Experimental Staphylococcal Endocarditis in Dogs: II. Penicillin-Sensitive Mutants Arising from Penicillin-Resistant Staphylococcus Aureus During the Course of Experimental Canine Endocarditis , AMA Arch Intern Med 105:668-674 ( (May) ) 1960.Crossref 4. Knox, R.: A New Penicillin (BRL 1241) Active Against Penicillin-Resistant Staphylococci , Brit Med J 2:690-693 ( (Sept) ) 1960.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jun 1, 1963

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