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Persistence of Staphylococcus to Methicillin and Oxacillin: Observations on Two Cases of Endocarditis

Persistence of Staphylococcus to Methicillin and Oxacillin: Observations on Two Cases of... Abstract The new penicillinase-resistant semisynthetic penicillins methicillin and oxacillin have proved effective against staphylococci in vitro and in vivo. They are considered the answer to the staphylococcal problem. It has been observed that the antibacterial activity of the new penicillins is much inferior to that of benzylpenicillin since a large number of bacteria survived despite their action.1-3,7 In using methicillin at first and oxacillin lately we have been struck by the slowness of response, especially of the septicemia and endocarditis patients. In the 2 representative cases that we describe here, Staphylococcus was isolated from the blood stream while the patients were under treatment with methicillin or oxacillin. A large number of survivors have been observed in in vitro experiments in high concentrations of the antibiotics. Report of Cases Case 1.— This patient was a 19-year-old male with a congenital aortic stenosis. Staphylococcal endocarditis was diagnosed in January, 1961. The fever References 1. Cillocycline was known before as penimpcycline. 2. Knox, R.: A New Penicillin (BRL 1241) Active Against Penicillin-Resistant Staphylococci , Brit. Med. J. 2:690-693, 1960.Crossref 3. Garrod, L. P.: The Relative Antibacterial Activity of 4 Penicillins , Brit. Med. J. 2:1695-1696, 1960.Crossref 4. Barber, M., and Waterworth, P. M.: Antibacterial Activity of the Penicillins , Brit. Med. J. 1:1159-1164, 1962.Crossref 5. Geraci, J. E.; Nichols, D. R., and Wellman, W. E.: Vancomycin in Serious Staphylococcal Infections , Arch. Intern. Med. 109:507-515, 1962.Crossref 6. Stewart, G. T.; Nixon, H. H.; Coles, H. M. T.; Kesson, C. W.; Lawson, D.; Thomas, R. G.; Mishra, J. N.; Mitchell, M. E.; Semmens, J. M., and Wade, T. H. H.: Report on Clinical Use of BRL 1241 in Children with Staphylococcal and Streptococcal Infections , Brit. Med. J. 2:703-706, 1960.Crossref 7. Fairbrother, R. W., and Taylor, G.: Sodium Methicillin in Routine Therapy , Lancet 1:473-476, 1961.Crossref 8. Feingold, S. M.; Monzon, O. T.; Sweeney, E. E.; Dangerfield, H. G.; Blackman, B. T., and Hewitt, W. L.: Laboratory Experiences with Dimethoxyphenyl Penicillin , in Symposium on the New Dimethoxyphenylpenicillin , State University of New York, Syracuse, N.Y., 1960, pp. 26-36. 9. Smith, J. M., and Counts, G. W.: Laboratory and Clinical Studies of Dimethoxyphenyl Penicillin, in Symposium,7 pp. 83-92. 10. Branch, A.; Rodger, K. C., and Power, E. E.: Clinical and Laboratory Experiences with Dimethoxyphenyl Penicillin, in Symposium,7 pp. 93-100. 11. Yow, E. M., and Nassar, H. A.: Report on the Laboratory and Clinical Evaluation of Dimethoxyphenyl Penicillin, in Symposium,7 pp. 183-193. 12. Hewitt, W. L.; Monzon, O.; Dangerfield, H. G.; Blackman, B.; Kudinoff, Z., and Finegold, S. M.: Clinical Experience with Dimethoxyphenyl Penicillin, in Symposium,7 pp. 127-145. 13. Bunn, P.; Knight, R., and Amberg, J.: Some Notes About Dimethoxyphenyl Penicillin, in Symposium,7 pp. 172-182. 14. Branch, A.; Rodger, K. C.; Tonning, H. O.; Lee, R. W., and Power, E. E.: Laboratory and Clinical Experiences with a New Oral Synthetic Penicillin, 5-Methyl-3-Phenyl-4-Isoxazolyl Penicillin , Canad. Med. Ass. J. 86:97-101, 1962. 15. Geraci, J. E.; Hoffmeister, R. T.; Nichols, D. R., and Needham, G. M.: Preliminary Clinical and Laboratory Experiences with a New Oral Penicillin: 5-Methyl-3-Phenyl-4-Isoxazolyl Penicillin , Proc. Mayo Clin. 37:137-149, 1962. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Persistence of Staphylococcus to Methicillin and Oxacillin: Observations on Two Cases of Endocarditis

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1963.03620300039007
Publisher site
See Article on Publisher Site

Abstract

Abstract The new penicillinase-resistant semisynthetic penicillins methicillin and oxacillin have proved effective against staphylococci in vitro and in vivo. They are considered the answer to the staphylococcal problem. It has been observed that the antibacterial activity of the new penicillins is much inferior to that of benzylpenicillin since a large number of bacteria survived despite their action.1-3,7 In using methicillin at first and oxacillin lately we have been struck by the slowness of response, especially of the septicemia and endocarditis patients. In the 2 representative cases that we describe here, Staphylococcus was isolated from the blood stream while the patients were under treatment with methicillin or oxacillin. A large number of survivors have been observed in in vitro experiments in high concentrations of the antibiotics. Report of Cases Case 1.— This patient was a 19-year-old male with a congenital aortic stenosis. Staphylococcal endocarditis was diagnosed in January, 1961. The fever References 1. Cillocycline was known before as penimpcycline. 2. Knox, R.: A New Penicillin (BRL 1241) Active Against Penicillin-Resistant Staphylococci , Brit. Med. J. 2:690-693, 1960.Crossref 3. Garrod, L. P.: The Relative Antibacterial Activity of 4 Penicillins , Brit. Med. J. 2:1695-1696, 1960.Crossref 4. Barber, M., and Waterworth, P. M.: Antibacterial Activity of the Penicillins , Brit. Med. J. 1:1159-1164, 1962.Crossref 5. Geraci, J. E.; Nichols, D. R., and Wellman, W. E.: Vancomycin in Serious Staphylococcal Infections , Arch. Intern. Med. 109:507-515, 1962.Crossref 6. Stewart, G. T.; Nixon, H. H.; Coles, H. M. T.; Kesson, C. W.; Lawson, D.; Thomas, R. G.; Mishra, J. N.; Mitchell, M. E.; Semmens, J. M., and Wade, T. H. H.: Report on Clinical Use of BRL 1241 in Children with Staphylococcal and Streptococcal Infections , Brit. Med. J. 2:703-706, 1960.Crossref 7. Fairbrother, R. W., and Taylor, G.: Sodium Methicillin in Routine Therapy , Lancet 1:473-476, 1961.Crossref 8. Feingold, S. M.; Monzon, O. T.; Sweeney, E. E.; Dangerfield, H. G.; Blackman, B. T., and Hewitt, W. L.: Laboratory Experiences with Dimethoxyphenyl Penicillin , in Symposium on the New Dimethoxyphenylpenicillin , State University of New York, Syracuse, N.Y., 1960, pp. 26-36. 9. Smith, J. M., and Counts, G. W.: Laboratory and Clinical Studies of Dimethoxyphenyl Penicillin, in Symposium,7 pp. 83-92. 10. Branch, A.; Rodger, K. C., and Power, E. E.: Clinical and Laboratory Experiences with Dimethoxyphenyl Penicillin, in Symposium,7 pp. 93-100. 11. Yow, E. M., and Nassar, H. A.: Report on the Laboratory and Clinical Evaluation of Dimethoxyphenyl Penicillin, in Symposium,7 pp. 183-193. 12. Hewitt, W. L.; Monzon, O.; Dangerfield, H. G.; Blackman, B.; Kudinoff, Z., and Finegold, S. M.: Clinical Experience with Dimethoxyphenyl Penicillin, in Symposium,7 pp. 127-145. 13. Bunn, P.; Knight, R., and Amberg, J.: Some Notes About Dimethoxyphenyl Penicillin, in Symposium,7 pp. 172-182. 14. Branch, A.; Rodger, K. C.; Tonning, H. O.; Lee, R. W., and Power, E. E.: Laboratory and Clinical Experiences with a New Oral Synthetic Penicillin, 5-Methyl-3-Phenyl-4-Isoxazolyl Penicillin , Canad. Med. Ass. J. 86:97-101, 1962. 15. Geraci, J. E.; Hoffmeister, R. T.; Nichols, D. R., and Needham, G. M.: Preliminary Clinical and Laboratory Experiences with a New Oral Penicillin: 5-Methyl-3-Phenyl-4-Isoxazolyl Penicillin , Proc. Mayo Clin. 37:137-149, 1962.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jun 1, 1963

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