Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Patent Ductus Arteriosus and Osteoarthropathy

Patent Ductus Arteriosus and Osteoarthropathy Abstract Patients who have a patent ductus arteriosus with pulmonary hypertension and reversal of shunt present with cyanosis of the lower extremities and clubbing of the toes.1-5 This paper describes an individual with patent ductus arteriosus and reversal of blood flow through the ductus in whom there is in addition hypertrophic osteoarthropathy involving the bones of the lower extremities only. Report of a Case A 24-year-old white female was first seen in the Cardiovascular Laboratory, University of Louisville, in September, 1956, whence she had been referred for physiological studies after a murmur had been heard during a routine physical examination. Questioning at that time revealed that a murmur was first detected when the patient was about 13 years old. She had noted mild dyspnea on exertion and ease of fatigability for as long as she could remember. However, there had been no significant progression of these symptoms, and she was References 1. London, F.; Stevenson, T. D.; Morrow, A. G., and Haller, J. A.: Patent Ductus Arteriosus with Reverse Flow , Southern Med. J. 50:160, 1957.Crossref 2. Kuhn, L. A.: Patent Ductus Arteriosus with Pulmonary Hypertension , J. Mount Sinai Hosp. N.Y. 25:103, 1958. 3. Hultgren, H.; Selzer, A.; Purdy, A.; Holman, E., and Gerbode, T.: The Syndrome of Patent Ductus Arteriosus with Pulmonary Hypertension , Circulation 8:15, 1953.Crossref 4. Taussig, H. B.; Bauersfeld, S. R., and MacDonald, A. J.: Pulmonary Hypertension with Persistent Patency of the Ductus Arteriosus , A.M.A. Amer. J. Dis. Child. 84:496, 1952. 5. Pritchard, W. H.; Brofman, B. L., and Hellerstein, H. K.: Clinical Studies in Reversal of Flow in Patent Ductus Arteriosus , J. Lab. Clin. Med. 36:974, 1950. 6. Laragh, J. H.: Interrelationships Between Angiotensin, Norepinephrine, Epinephrine, Aldosterone Secretion, and Electrolyte Metabolism in Man , Circulation 25:203, 1962.Crossref 7. Mendlowitz, M.: Clubbing and Hypertrophic Osteoarthropathy , Medicine (Balt.) 21:269, 1942. 8. Ortner, W.: Klinische Symptomatologie innerer Krankheiten , Berlin, Urgan and Schwarzenberg, 1926, pp. 298, 307, cited by Mendlowitz.7 9. Gluzinski, A.: Maries Osteoarthropathie hypertrophiante , Deutsch. Med. Wschr. 37:2052, 1911. 10. Bamberger, E.: Über Knochenveränderungen bei chronischen Lungen- und Herzkrankheiten , Z. Klin. Med. 18:193, 1891, cited by Kahn.12 11. Shaw, H. B., and Cooper, R. H.: "Pulmonary Hypertrophic Osteoarthropathy" Occurring in a Case of Congenital Heart Disease (!) , Lancet 1: 880, 1907.Crossref 12. Kahn, D.: Clubbing and Hypertrophic Osteoarthropathy , A.M.A. Arch. Intern. Med. 100:147, 1957.Crossref 13. Trever, R. W.: Hypertrophic Osteoarthropathy in Association with Congenital Cyanotic Heart Disease: Report of 2 Cases , Ann. Intern. Med. 48:660, 1958.Crossref 14. Means, M. G., and Brown, N. W.: Secondary Hypertrophic Osteoarthropathy in Congenital Heart Disease , Amer. Heart J. 34:262, 1947.Crossref 15. Gall, E. A.; Bennett, G. A., and Bauer, W.: Generalized Hypertrophic Osteoarthropathy , Amer. J. Path. 27:349, 1951. 16. Kennedy, R. L. J.: Hypertrophic Pulmonary Osteo-Arthropathy in Infants and in Children , Amer. J. Dis. Child. 54:795, 1937. 17. Ray, E. S., and Fisher, H. P., Jr.: Hypertrophic Osteoarthropathy in Pulmonary Malignancies , Ann. Intern. Med. 38:239, 1953.Crossref 18. White, P. D., and Sprague, H. B.: The Tetralogy of Fallot: Report of a Case in a Noted Musician, Who Lived to His Sixtieth Year , J.A.M.A. 92:787, 1929.Crossref 19. Cushing, E. H.: Clubbed Fingers and Hypertrophic Pulmonary Osteoarthropathy , Int. Clin. 2:200, 1937. 20. Hyman, C. H., and Herrick, T. P.: Chronic Osteo-Arthropathy , J.A.M.A. 78:1043, 1922.Crossref 21. Hammarsten, J. F., and O'Leary, J.: The Features and Significance of Hypertrophic Osteoarthropathy , A.M.A. Arch. Intern. Med. 99:431, 1957.Crossref 22. Vogl, A.; Blumenfeld, S., and Gutner, L. B.: Diagnostic Significance of Pulmonary Hypertrophic Osteoarthropathy , Amer. J. Med. 18:51, 1955.Crossref 23. Holling, H. E., and Brodey, R. S.: Pulmonary Hypertrophic Osteoarthropathy , J.A.M.A. 178:977, 1961.Crossref 24. Mendlowitz, M., and Leslie, A.: The Experimental Simulation in the Dog of Cyanosis and Hypertrophic Osteoarthropathy Which Are Associated with Congenital Heart Disease , Amer. Heart J. 24:141, 1942.Crossref 25. Ginsberg, J.: Observations on the Peripheral Circulation in Hypertrophic Pulmonary Osteoarthropathy , Quart. J. Med. 27:335, 1958. 26. Clubbing of the Fingers and Osteoarthropathy, Leading Article , Lancet 2:390, 1959. 27. Dailey, F. H.; Genovese, P. D., and Behnke, R. H.: Patent Ductus Arteriosus with Reversal of Flow in Adults , Ann. Intern. Med. 56:865, 1962.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Loading next page...
 
/lp/american-medical-association/patent-ductus-arteriosus-and-osteoarthropathy-UIFNq5wkoF

References (30)

Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1963.03620270072011
Publisher site
See Article on Publisher Site

Abstract

Abstract Patients who have a patent ductus arteriosus with pulmonary hypertension and reversal of shunt present with cyanosis of the lower extremities and clubbing of the toes.1-5 This paper describes an individual with patent ductus arteriosus and reversal of blood flow through the ductus in whom there is in addition hypertrophic osteoarthropathy involving the bones of the lower extremities only. Report of a Case A 24-year-old white female was first seen in the Cardiovascular Laboratory, University of Louisville, in September, 1956, whence she had been referred for physiological studies after a murmur had been heard during a routine physical examination. Questioning at that time revealed that a murmur was first detected when the patient was about 13 years old. She had noted mild dyspnea on exertion and ease of fatigability for as long as she could remember. However, there had been no significant progression of these symptoms, and she was References 1. London, F.; Stevenson, T. D.; Morrow, A. G., and Haller, J. A.: Patent Ductus Arteriosus with Reverse Flow , Southern Med. J. 50:160, 1957.Crossref 2. Kuhn, L. A.: Patent Ductus Arteriosus with Pulmonary Hypertension , J. Mount Sinai Hosp. N.Y. 25:103, 1958. 3. Hultgren, H.; Selzer, A.; Purdy, A.; Holman, E., and Gerbode, T.: The Syndrome of Patent Ductus Arteriosus with Pulmonary Hypertension , Circulation 8:15, 1953.Crossref 4. Taussig, H. B.; Bauersfeld, S. R., and MacDonald, A. J.: Pulmonary Hypertension with Persistent Patency of the Ductus Arteriosus , A.M.A. Amer. J. Dis. Child. 84:496, 1952. 5. Pritchard, W. H.; Brofman, B. L., and Hellerstein, H. K.: Clinical Studies in Reversal of Flow in Patent Ductus Arteriosus , J. Lab. Clin. Med. 36:974, 1950. 6. Laragh, J. H.: Interrelationships Between Angiotensin, Norepinephrine, Epinephrine, Aldosterone Secretion, and Electrolyte Metabolism in Man , Circulation 25:203, 1962.Crossref 7. Mendlowitz, M.: Clubbing and Hypertrophic Osteoarthropathy , Medicine (Balt.) 21:269, 1942. 8. Ortner, W.: Klinische Symptomatologie innerer Krankheiten , Berlin, Urgan and Schwarzenberg, 1926, pp. 298, 307, cited by Mendlowitz.7 9. Gluzinski, A.: Maries Osteoarthropathie hypertrophiante , Deutsch. Med. Wschr. 37:2052, 1911. 10. Bamberger, E.: Über Knochenveränderungen bei chronischen Lungen- und Herzkrankheiten , Z. Klin. Med. 18:193, 1891, cited by Kahn.12 11. Shaw, H. B., and Cooper, R. H.: "Pulmonary Hypertrophic Osteoarthropathy" Occurring in a Case of Congenital Heart Disease (!) , Lancet 1: 880, 1907.Crossref 12. Kahn, D.: Clubbing and Hypertrophic Osteoarthropathy , A.M.A. Arch. Intern. Med. 100:147, 1957.Crossref 13. Trever, R. W.: Hypertrophic Osteoarthropathy in Association with Congenital Cyanotic Heart Disease: Report of 2 Cases , Ann. Intern. Med. 48:660, 1958.Crossref 14. Means, M. G., and Brown, N. W.: Secondary Hypertrophic Osteoarthropathy in Congenital Heart Disease , Amer. Heart J. 34:262, 1947.Crossref 15. Gall, E. A.; Bennett, G. A., and Bauer, W.: Generalized Hypertrophic Osteoarthropathy , Amer. J. Path. 27:349, 1951. 16. Kennedy, R. L. J.: Hypertrophic Pulmonary Osteo-Arthropathy in Infants and in Children , Amer. J. Dis. Child. 54:795, 1937. 17. Ray, E. S., and Fisher, H. P., Jr.: Hypertrophic Osteoarthropathy in Pulmonary Malignancies , Ann. Intern. Med. 38:239, 1953.Crossref 18. White, P. D., and Sprague, H. B.: The Tetralogy of Fallot: Report of a Case in a Noted Musician, Who Lived to His Sixtieth Year , J.A.M.A. 92:787, 1929.Crossref 19. Cushing, E. H.: Clubbed Fingers and Hypertrophic Pulmonary Osteoarthropathy , Int. Clin. 2:200, 1937. 20. Hyman, C. H., and Herrick, T. P.: Chronic Osteo-Arthropathy , J.A.M.A. 78:1043, 1922.Crossref 21. Hammarsten, J. F., and O'Leary, J.: The Features and Significance of Hypertrophic Osteoarthropathy , A.M.A. Arch. Intern. Med. 99:431, 1957.Crossref 22. Vogl, A.; Blumenfeld, S., and Gutner, L. B.: Diagnostic Significance of Pulmonary Hypertrophic Osteoarthropathy , Amer. J. Med. 18:51, 1955.Crossref 23. Holling, H. E., and Brodey, R. S.: Pulmonary Hypertrophic Osteoarthropathy , J.A.M.A. 178:977, 1961.Crossref 24. Mendlowitz, M., and Leslie, A.: The Experimental Simulation in the Dog of Cyanosis and Hypertrophic Osteoarthropathy Which Are Associated with Congenital Heart Disease , Amer. Heart J. 24:141, 1942.Crossref 25. Ginsberg, J.: Observations on the Peripheral Circulation in Hypertrophic Pulmonary Osteoarthropathy , Quart. J. Med. 27:335, 1958. 26. Clubbing of the Fingers and Osteoarthropathy, Leading Article , Lancet 2:390, 1959. 27. Dailey, F. H.; Genovese, P. D., and Behnke, R. H.: Patent Ductus Arteriosus with Reversal of Flow in Adults , Ann. Intern. Med. 56:865, 1962.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1963

There are no references for this article.