Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Differential Diagnosis of Jaundice: Modified I131-Labeled Rose Bengal Test

Differential Diagnosis of Jaundice: Modified I131-Labeled Rose Bengal Test Abstract Reports on the use of I131-labeled rose bengal (RBI131) to help distinguish between the principal causes for jaundice have not been in agreement. Some observers have found the test to be of value,1-12 while others have concluded that it was unreliable13-15 when used for this purpose. Since the methods employed by these investigators were not always the same, the variation in the results obtained may be partially explainable by differences in technique. In the latter part of 1959, we began a series of studies dealing with hepatic uptake and excretion of RBI131 in experimental animals and man. A modified test16 that ultimately evolved from these studies seemed to hold promise as an aid in the differential diagnosis of jaundice.17 We wish in this communication to present some additional observations and to describe our experience to date with the use of the modified References 1. Wood, J. A., and Korst, D. R.: Clinical Studies with Radioiodine Rose Bengal Dye , Clin. Res. Proc. 5:210, 1957. 2. Taplin, G. V.; Meredith, O. M., Jr., and Kade, H.: Development of a Radioisotope Tracer Test for the Differential Diagnosis of Jaundice: The Rose Bengal I131 Hepatogram , J. Louisiana Med. Soc. 109: 255, 1957. 3. Geppert, L. J., and Brent, R. L.: Radioactive Rose Bengal: An Aid in the Differential Diagnosis of the Jaundiced Infant , A.M.A. J. Dis. Child. 94: 544, 1957. 4. Nordyke, R. A., and Blahd, W. H.: The Differential Diagnosis of Biliary Tract Obstruction with Radioactive Rose Bengal , J. Lab. Clin. Med. 51: 565, 1958. 5. Nordyke, R. A.: Diagnosis of Distal Common Bile Duct Obstruction with Radioactivated Rose Bengal , Clin. Res. 7:295, 1959. 6. Taplin, G. V.; Meredith, O. M., Jr.; Winter, C. C., and Johnson, D.: Rose Bengal and Iodopyracet as Radiodiagnostic Agents in Liver and Kidney Diseases , Ann. N.Y. Acad. Sci. 78:872, 1959.Crossref 7. Lum, C. H.; Marshall, W. J.; Kozoll, D. D., and Meyer, K. A.: The Use of Radioactive (I131-Labeled) Rose Bengal in the Study of Human Liver Disease: Its Correlation with Liver Function Tests , Ann. Surg. 149:353, 1959.Crossref 8. Brent, R. L., and Geppert, L. J.: Use of Radioactive Rose Bengal in the Evaluation of Infantile Jaundice , A.M.A. J. Dis. Child. 98:720, 1959. 9. Garcia, A. M.; Ahmad, K.; Wegst, A. V., and Beierwaltes, W. H.: I131-Rose Bengal Test of Liver Function: A Clinical Evaluation , Gastroenterology 37:725, 1959. 10. Nordyke, R. A.: Radioiodinated Rose Bengal in Liver and Biliary Tract Function Testing: A Reappraisal , Gastroenterology 39:258, 1960. 11. Ghadimi, H., and Sass-Kortsak, A.: Evaluation of the Radioactive Rose-Bengal Test for the Differential Diagnosis of Obstructive Jaundice in Infants , New Engl. J. Med. 265:351, 1961.Crossref 12. Wagner, H. N., Jr.; McAfee, J. G., and Mozley, J. M.: Diagnosis of Liver Disease by Radioisotope Scanning , Arch. Intern. Med. 107:324, 1961.Crossref 13. Brown, C. H., and Glasser, O.: Radioactive (I131-Tagged) Rose Bengal Liver Function Test , J. Lab. Clin. Med. 48:454, 1956. 14. Cohn, E. M.; Zagerman, J.; Sklaroff, D. M., and Tumen, H. J.: The Use of Radioactive Rose Bengal as a Test in the Differential Diagnosis of Jaundice , Amer. J. Gastroent. 28:621, 1957. 15. Richman, A., and Jacobs, W.: The Radioactive (I131) Rose Bengal Test of Liver Function , J. Mount Sinai Hosp. N.Y. 27:600, 1960. 16. Kawaguchi, M.; Soble, A. R., and Berk, J. E.: Studies with I131-Labeled Rose Bengal: I. Derivation of a Technic for Use in the Differential Diagnosis of Jaundice , Amer. J. Dig. Dis. 7:289, 1962.Crossref 17. Kawaguchi, M.; Berk, J. E., and Soble, A. R.: Studies with I131-Labeled Rose Bengal: II. Clinical Evaluation of a Modified Technic for Differential Diagnosis of Jaundice , Amer. J. Dig. Dis. 7:300, 1962.Crossref 18. Gutman, A. B.: Serum Alkaline Phosphatase Activity in Diseases of the Skeletal and Hepatobiliary Systems: A Consideration of the Current Status , Amer. J. Med. 27:875, 1959.Crossref 19. Meurman, L.: On the Distribution and Kinetics of Injected I131 Rose Bengal: An Experimental Study with Special Reference to the Evaluation of Liver Function; Chapter IX. Behavior of I131 Rose Bengal in Bile-Duct Obstructed Animals , Acta Med. Scand. ( (Suppl. 354) ):60-67, 1960. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Differential Diagnosis of Jaundice: Modified I131-Labeled Rose Bengal Test

Download PDF
7 pages

Loading next page...
 
/lp/american-medical-association/differential-diagnosis-of-jaundice-modified-i131-labeled-rose-bengal-Usopup0rcp

References (19)

Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1963.03620270049008
Publisher site
See Article on Publisher Site

Abstract

Abstract Reports on the use of I131-labeled rose bengal (RBI131) to help distinguish between the principal causes for jaundice have not been in agreement. Some observers have found the test to be of value,1-12 while others have concluded that it was unreliable13-15 when used for this purpose. Since the methods employed by these investigators were not always the same, the variation in the results obtained may be partially explainable by differences in technique. In the latter part of 1959, we began a series of studies dealing with hepatic uptake and excretion of RBI131 in experimental animals and man. A modified test16 that ultimately evolved from these studies seemed to hold promise as an aid in the differential diagnosis of jaundice.17 We wish in this communication to present some additional observations and to describe our experience to date with the use of the modified References 1. Wood, J. A., and Korst, D. R.: Clinical Studies with Radioiodine Rose Bengal Dye , Clin. Res. Proc. 5:210, 1957. 2. Taplin, G. V.; Meredith, O. M., Jr., and Kade, H.: Development of a Radioisotope Tracer Test for the Differential Diagnosis of Jaundice: The Rose Bengal I131 Hepatogram , J. Louisiana Med. Soc. 109: 255, 1957. 3. Geppert, L. J., and Brent, R. L.: Radioactive Rose Bengal: An Aid in the Differential Diagnosis of the Jaundiced Infant , A.M.A. J. Dis. Child. 94: 544, 1957. 4. Nordyke, R. A., and Blahd, W. H.: The Differential Diagnosis of Biliary Tract Obstruction with Radioactive Rose Bengal , J. Lab. Clin. Med. 51: 565, 1958. 5. Nordyke, R. A.: Diagnosis of Distal Common Bile Duct Obstruction with Radioactivated Rose Bengal , Clin. Res. 7:295, 1959. 6. Taplin, G. V.; Meredith, O. M., Jr.; Winter, C. C., and Johnson, D.: Rose Bengal and Iodopyracet as Radiodiagnostic Agents in Liver and Kidney Diseases , Ann. N.Y. Acad. Sci. 78:872, 1959.Crossref 7. Lum, C. H.; Marshall, W. J.; Kozoll, D. D., and Meyer, K. A.: The Use of Radioactive (I131-Labeled) Rose Bengal in the Study of Human Liver Disease: Its Correlation with Liver Function Tests , Ann. Surg. 149:353, 1959.Crossref 8. Brent, R. L., and Geppert, L. J.: Use of Radioactive Rose Bengal in the Evaluation of Infantile Jaundice , A.M.A. J. Dis. Child. 98:720, 1959. 9. Garcia, A. M.; Ahmad, K.; Wegst, A. V., and Beierwaltes, W. H.: I131-Rose Bengal Test of Liver Function: A Clinical Evaluation , Gastroenterology 37:725, 1959. 10. Nordyke, R. A.: Radioiodinated Rose Bengal in Liver and Biliary Tract Function Testing: A Reappraisal , Gastroenterology 39:258, 1960. 11. Ghadimi, H., and Sass-Kortsak, A.: Evaluation of the Radioactive Rose-Bengal Test for the Differential Diagnosis of Obstructive Jaundice in Infants , New Engl. J. Med. 265:351, 1961.Crossref 12. Wagner, H. N., Jr.; McAfee, J. G., and Mozley, J. M.: Diagnosis of Liver Disease by Radioisotope Scanning , Arch. Intern. Med. 107:324, 1961.Crossref 13. Brown, C. H., and Glasser, O.: Radioactive (I131-Tagged) Rose Bengal Liver Function Test , J. Lab. Clin. Med. 48:454, 1956. 14. Cohn, E. M.; Zagerman, J.; Sklaroff, D. M., and Tumen, H. J.: The Use of Radioactive Rose Bengal as a Test in the Differential Diagnosis of Jaundice , Amer. J. Gastroent. 28:621, 1957. 15. Richman, A., and Jacobs, W.: The Radioactive (I131) Rose Bengal Test of Liver Function , J. Mount Sinai Hosp. N.Y. 27:600, 1960. 16. Kawaguchi, M.; Soble, A. R., and Berk, J. E.: Studies with I131-Labeled Rose Bengal: I. Derivation of a Technic for Use in the Differential Diagnosis of Jaundice , Amer. J. Dig. Dis. 7:289, 1962.Crossref 17. Kawaguchi, M.; Berk, J. E., and Soble, A. R.: Studies with I131-Labeled Rose Bengal: II. Clinical Evaluation of a Modified Technic for Differential Diagnosis of Jaundice , Amer. J. Dig. Dis. 7:300, 1962.Crossref 18. Gutman, A. B.: Serum Alkaline Phosphatase Activity in Diseases of the Skeletal and Hepatobiliary Systems: A Consideration of the Current Status , Amer. J. Med. 27:875, 1959.Crossref 19. Meurman, L.: On the Distribution and Kinetics of Injected I131 Rose Bengal: An Experimental Study with Special Reference to the Evaluation of Liver Function; Chapter IX. Behavior of I131 Rose Bengal in Bile-Duct Obstructed Animals , Acta Med. Scand. ( (Suppl. 354) ):60-67, 1960.

Journal

Archives of Internal Medicine – American Medical Association

Published: Mar 1, 1963

There are no references for this article.