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Erythromycin in Treatment of Early Syphilis

Erythromycin in Treatment of Early Syphilis Abstract While the treponemicidal properties of erythromycin were first described in 1953 by Keller and Morton,1 it is only recently that adequate clinical information has become available. Keller and Morton, as well as Turner and Schaeffer,2 were able to demonstrate Treponema pallidum more susceptible to the action of erythromycin than other antibiotics with the exception of penicillin. Later, Kolmer3 reported similar treponemicidal properties to erythromycin but obtained superior results with several other antibiotics. In 1954 Alexander and Schoch4 treated 4 patients with syphilitic lesions with erythromycin and observed rapid disappearance of Treponema pallidum from the lesions. In 1956 Montero5 presented 27 patients with early syphilis treated with a total of 9 to 12 gm. of erythromycin with satisfactory results. In 1959 Montgomery and Knox6 reported on 40 darkfield-positive cases of early syphilis treated with 9 to 10 gm. of erythromycin stearate over a period of References 1. Keller, R., and Morton, H. E.: Susceptibilities of Kazan, Nichols, and Reiter Strains of Treponema and Pleuropneumonia-like Organisms to Antibiotic Erythromycin (Ilotycin) , Am. J. Syph. 37:379-382 ( (July) ) 1953. 2. Turner, T. B., and Schaeffer, K.: The Comparative Effect of Various Antibiotics in Experimental Syphilis , Am. J. Syph. 38:81-91 ( (March) ) 1954. 3. Kolmer, J. A.: A Comparative Study of 10 Antibiotic Compounds in the Treatment of Experimental Syphilis of Rabbits , Antibiotics Ann. 1955-1956, pp. 592-595. 4. Alexander, L. J., and Schoch, A. G.: Erythromycin in Venereal Diseases , Am. J. Syph. 38:107-109 ( (March) ) 1954. 5. Montero, O.: Evaluation of Erythromycin in Early Syphilis , presented at the First International Symposium on Venereal Disease and the Treponematoses, Washington, D.C., May 28-June 1, 1956 . 6. Montgomery, C. H., and Knox, J. M.: Erythromycin in the Treatment of Early Syphilis , A.M.A. Arch. Dermat. 80:205-209 ( (Aug.) ) 1959.Crossref 7. Iskrant, A. P.; Bowman, R. W., and Donohue, J. F.: Techniques in Evaluation of Rapid Antisyphilitic Therapy , Public Health Rep. 63: 965-977 ( (July 23) ) 1958.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1961.03620050098010
Publisher site
See Article on Publisher Site

Abstract

Abstract While the treponemicidal properties of erythromycin were first described in 1953 by Keller and Morton,1 it is only recently that adequate clinical information has become available. Keller and Morton, as well as Turner and Schaeffer,2 were able to demonstrate Treponema pallidum more susceptible to the action of erythromycin than other antibiotics with the exception of penicillin. Later, Kolmer3 reported similar treponemicidal properties to erythromycin but obtained superior results with several other antibiotics. In 1954 Alexander and Schoch4 treated 4 patients with syphilitic lesions with erythromycin and observed rapid disappearance of Treponema pallidum from the lesions. In 1956 Montero5 presented 27 patients with early syphilis treated with a total of 9 to 12 gm. of erythromycin with satisfactory results. In 1959 Montgomery and Knox6 reported on 40 darkfield-positive cases of early syphilis treated with 9 to 10 gm. of erythromycin stearate over a period of References 1. Keller, R., and Morton, H. E.: Susceptibilities of Kazan, Nichols, and Reiter Strains of Treponema and Pleuropneumonia-like Organisms to Antibiotic Erythromycin (Ilotycin) , Am. J. Syph. 37:379-382 ( (July) ) 1953. 2. Turner, T. B., and Schaeffer, K.: The Comparative Effect of Various Antibiotics in Experimental Syphilis , Am. J. Syph. 38:81-91 ( (March) ) 1954. 3. Kolmer, J. A.: A Comparative Study of 10 Antibiotic Compounds in the Treatment of Experimental Syphilis of Rabbits , Antibiotics Ann. 1955-1956, pp. 592-595. 4. Alexander, L. J., and Schoch, A. G.: Erythromycin in Venereal Diseases , Am. J. Syph. 38:107-109 ( (March) ) 1954. 5. Montero, O.: Evaluation of Erythromycin in Early Syphilis , presented at the First International Symposium on Venereal Disease and the Treponematoses, Washington, D.C., May 28-June 1, 1956 . 6. Montgomery, C. H., and Knox, J. M.: Erythromycin in the Treatment of Early Syphilis , A.M.A. Arch. Dermat. 80:205-209 ( (Aug.) ) 1959.Crossref 7. Iskrant, A. P.; Bowman, R. W., and Donohue, J. F.: Techniques in Evaluation of Rapid Antisyphilitic Therapy , Public Health Rep. 63: 965-977 ( (July 23) ) 1958.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: May 1, 1961

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