Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Withdrawal of Adrenal Steroids and Corticotropin: Clinical Observations in Chronic Ulcerative Colitis

Withdrawal of Adrenal Steroids and Corticotropin: Clinical Observations in Chronic Ulcerative... Abstract Adrenal steroids are widely used in the management of ulcerative colitis but agreement on their use is not universal. Opinions vary as to the efficacy of these substances in the management of the disease,1-12 their role in the production of complications,11,13-18 and their role in the production of systemic complications unrelated to the disease.19,20 Most authors agree that steroid substances may be beneficial and are indicated in the treatment of some complications of ulcerative colitis, such as iritis, arthritis, and severe erythema nodosum. Short-term use may be beneficial in some acutely ill patients to obtain improved appetite and a feeling of well-being. Opinions vary as to the use of long-term courses of treatment with these substances. Supportive measures, including adequate rest, diet, use of vitamin supplements, symptomatic medication, use of sedatives and antispasmodics, blood transfusion, and replacement of fluid and electrolyte losses, form the basic program of References 1. Dearing, W. H., and Brown, P. W.: Experiences with Cortisone and ACTH in Chronic Ulcerative Colitis , Proc. Staff Meet. Mayo Clin. 25:486-488 ( (Aug. 16) ) 1950. 2. Machella, T. E., and Hollan, O. R.: The Effect of Cortisone on the Clinical Course of Chronic Regional Enteritis and Chronic Idiopathic Ulcerative Colitis , Am. J.M. Sc. 221:501-507 ( (May) ) 1951.Crossref 3. Redish, M. H.: Failure of Cortisone in Chronic Ulcerative Disease of the Large and Small Bowel , Gastroenterology 18:179-183 ( (June) ) 1951. 4. Gray, S. J.; Reifenstein, R. W.; Benson, J. A., Jr., and Young, J. C. G.: Treatment of Ulcerative Colitis with Corticotropin (ACTH) and Cortisone , J.A.M.A. 148:1489-1497 ( (April 26) ) 1952.Crossref 5. Kirsner, J. B., and Palmer, W. L.: Ulcerative Colitis: Therapeutic Effects of Corticotropin and Cortisone in 120 Patients , Ann. Int. Med. 41: 232-250 ( (Aug.) ) 1954.Crossref 6. Cole, W. A.: The Future of ACTH and Cortisone in Surgery , editorial, Am. Surgeon 21: 1250-1252 ( (Dec.) ) 1955. 7. Hayes, M. A., and Kushlan, S. D.: Influence of Hormonal Therapy for Ulcerative Colitis upon the Course of Surgical Treatment , Gastroenterology 30:75-84 ( (Jan.) ) 1956. 8. Richman, A.; Sternlieb, I., and Winklestein, A.: ACTH and Cortisone Therapy in Ulcerative Colitis , Am. J. Digest. Dis. 1:206-214 ( (May) ) 1956.Crossref 9. Elliott, J. M., and Carbone, J. V.: The Long-Term Treatment of Ulcerative Colitis with Hydrocortisone, Prednisone, and Prednisolone , Gastroenterology 33:423-433 ( (Sept.) ) 1957. 10. Kiefer, E. D.: Steroid Hormones in the Management of Chronic Ulcerative Colitis , Dis. Colon & Rectum 1:15-22 ( (Jan.) -Feb.) 1958. 11. Rosenak, B. D.; Pickett, R. D.; Van Vactor, H. D.; Hammond, J. B.; Healey, R. J., and Moser, R. H.: The Present Status of the Treatment of Chronic Ulcerative Colitis with Steroid Hormones , Gastroenterology 34:879-891 ( (May) ) 1958. 12. Kirsner, J. B.; Palmer, W. L.; Spencer, J. A.; Bicks, R. O., and Johnson, C. F.: Corticotropin (ACTH) and the Adrenal Steroids in the Management of Ulcerative Colitis: Observations in 240 Patients , Ann. Int. Med. 50:891-927 ( (April) ) 1959. 13. Sloan, S.; Briggs, J. D., and Halsted, J. A.: ACTH Therapy for Ulcerative Colitis Complicated by Perforation of Coexisting Peptic Ulcer , Gastroenterology 18:438-442 ( (July) ) 1951. 14. Bargen, J. A.: Discussion on Schlitt, R. J.; McNally, J. J.; Shafiroff, B. G. P., and Hinton, J. W.: Pelvic Autonomic Neurectomy for Ulcerative Colitis , Gastroenterology 19:818-819 ( (Dec.) ) 1951. 15. Tulin, M.; Kern, F., Jr., and Almy, T. P.: Perforation of Bowel During Treatment of Ulcerative Colitis with Corticotropin: Report of 3 Cases , J.A.M.A. 150:559-562 ( (Oct. 11) ) 1952. 16. Sauer, W. G.; Dearing, W. H., and Wollaeger, E. E.: Serious Untoward Gastrointestinal Manifestations Possibly Related to Administration of Cortisone and Corticotropin , Proc. Staff Meet. Mayo Clin. 28:641-649 ( (Nov. 18) ) 1953. 17. Texter, E. C., Jr.; Legerton, C. W., Jr.; Ruffin, J. M.; Boyd, J. A., Jr., and Smith, A. G.: Idiopathic Ulcerative Colitis: Giant Ulceration Following Corticotropin (ACTH) and Cortisone Therapy, A.M.A. Arch. Int. Med. 91:744-757 ( (June) ) 1953. 18. Goldgraber, M. B.; Kirsner, J. B., and Palmer, W. L.: The Role of ACTH and Adrenal Steroids in Perforation of the Colon in Ulcerative Colitis: A Clinical-Pathologic Study , Gastroenterology 33:434-456 ( (Sept.) ) 1957. 19. Salassa, R. M.; Bennett, W. A.; Keating, F. R., Jr., and Sprague, R. G.: Postoperative Adrenal Cortical Insufficiency: Occurrence in Patients Previously Treated with Cortisone , J.A.M.A. 152:1509-1515 ( (Aug. 15) ) 1953. 20. Salassa, R. M.; Keating, F. R., Jr., and Sprague, R. G.: Clinical Aspects of Suppression of Adrenal Cortical Function after Use of Cortisone , Proc. Staff Meet. Mayo Clin. 28:662-668 ( (Nov. 18) ) 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Withdrawal of Adrenal Steroids and Corticotropin: Clinical Observations in Chronic Ulcerative Colitis

Download PDF
7 pages

Loading next page...
 
/lp/american-medical-association/withdrawal-of-adrenal-steroids-and-corticotropin-clinical-observations-2ciT2Gx1qf

References (22)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1961.03620010092015
Publisher site
See Article on Publisher Site

Abstract

Abstract Adrenal steroids are widely used in the management of ulcerative colitis but agreement on their use is not universal. Opinions vary as to the efficacy of these substances in the management of the disease,1-12 their role in the production of complications,11,13-18 and their role in the production of systemic complications unrelated to the disease.19,20 Most authors agree that steroid substances may be beneficial and are indicated in the treatment of some complications of ulcerative colitis, such as iritis, arthritis, and severe erythema nodosum. Short-term use may be beneficial in some acutely ill patients to obtain improved appetite and a feeling of well-being. Opinions vary as to the use of long-term courses of treatment with these substances. Supportive measures, including adequate rest, diet, use of vitamin supplements, symptomatic medication, use of sedatives and antispasmodics, blood transfusion, and replacement of fluid and electrolyte losses, form the basic program of References 1. Dearing, W. H., and Brown, P. W.: Experiences with Cortisone and ACTH in Chronic Ulcerative Colitis , Proc. Staff Meet. Mayo Clin. 25:486-488 ( (Aug. 16) ) 1950. 2. Machella, T. E., and Hollan, O. R.: The Effect of Cortisone on the Clinical Course of Chronic Regional Enteritis and Chronic Idiopathic Ulcerative Colitis , Am. J.M. Sc. 221:501-507 ( (May) ) 1951.Crossref 3. Redish, M. H.: Failure of Cortisone in Chronic Ulcerative Disease of the Large and Small Bowel , Gastroenterology 18:179-183 ( (June) ) 1951. 4. Gray, S. J.; Reifenstein, R. W.; Benson, J. A., Jr., and Young, J. C. G.: Treatment of Ulcerative Colitis with Corticotropin (ACTH) and Cortisone , J.A.M.A. 148:1489-1497 ( (April 26) ) 1952.Crossref 5. Kirsner, J. B., and Palmer, W. L.: Ulcerative Colitis: Therapeutic Effects of Corticotropin and Cortisone in 120 Patients , Ann. Int. Med. 41: 232-250 ( (Aug.) ) 1954.Crossref 6. Cole, W. A.: The Future of ACTH and Cortisone in Surgery , editorial, Am. Surgeon 21: 1250-1252 ( (Dec.) ) 1955. 7. Hayes, M. A., and Kushlan, S. D.: Influence of Hormonal Therapy for Ulcerative Colitis upon the Course of Surgical Treatment , Gastroenterology 30:75-84 ( (Jan.) ) 1956. 8. Richman, A.; Sternlieb, I., and Winklestein, A.: ACTH and Cortisone Therapy in Ulcerative Colitis , Am. J. Digest. Dis. 1:206-214 ( (May) ) 1956.Crossref 9. Elliott, J. M., and Carbone, J. V.: The Long-Term Treatment of Ulcerative Colitis with Hydrocortisone, Prednisone, and Prednisolone , Gastroenterology 33:423-433 ( (Sept.) ) 1957. 10. Kiefer, E. D.: Steroid Hormones in the Management of Chronic Ulcerative Colitis , Dis. Colon & Rectum 1:15-22 ( (Jan.) -Feb.) 1958. 11. Rosenak, B. D.; Pickett, R. D.; Van Vactor, H. D.; Hammond, J. B.; Healey, R. J., and Moser, R. H.: The Present Status of the Treatment of Chronic Ulcerative Colitis with Steroid Hormones , Gastroenterology 34:879-891 ( (May) ) 1958. 12. Kirsner, J. B.; Palmer, W. L.; Spencer, J. A.; Bicks, R. O., and Johnson, C. F.: Corticotropin (ACTH) and the Adrenal Steroids in the Management of Ulcerative Colitis: Observations in 240 Patients , Ann. Int. Med. 50:891-927 ( (April) ) 1959. 13. Sloan, S.; Briggs, J. D., and Halsted, J. A.: ACTH Therapy for Ulcerative Colitis Complicated by Perforation of Coexisting Peptic Ulcer , Gastroenterology 18:438-442 ( (July) ) 1951. 14. Bargen, J. A.: Discussion on Schlitt, R. J.; McNally, J. J.; Shafiroff, B. G. P., and Hinton, J. W.: Pelvic Autonomic Neurectomy for Ulcerative Colitis , Gastroenterology 19:818-819 ( (Dec.) ) 1951. 15. Tulin, M.; Kern, F., Jr., and Almy, T. P.: Perforation of Bowel During Treatment of Ulcerative Colitis with Corticotropin: Report of 3 Cases , J.A.M.A. 150:559-562 ( (Oct. 11) ) 1952. 16. Sauer, W. G.; Dearing, W. H., and Wollaeger, E. E.: Serious Untoward Gastrointestinal Manifestations Possibly Related to Administration of Cortisone and Corticotropin , Proc. Staff Meet. Mayo Clin. 28:641-649 ( (Nov. 18) ) 1953. 17. Texter, E. C., Jr.; Legerton, C. W., Jr.; Ruffin, J. M.; Boyd, J. A., Jr., and Smith, A. G.: Idiopathic Ulcerative Colitis: Giant Ulceration Following Corticotropin (ACTH) and Cortisone Therapy, A.M.A. Arch. Int. Med. 91:744-757 ( (June) ) 1953. 18. Goldgraber, M. B.; Kirsner, J. B., and Palmer, W. L.: The Role of ACTH and Adrenal Steroids in Perforation of the Colon in Ulcerative Colitis: A Clinical-Pathologic Study , Gastroenterology 33:434-456 ( (Sept.) ) 1957. 19. Salassa, R. M.; Bennett, W. A.; Keating, F. R., Jr., and Sprague, R. G.: Postoperative Adrenal Cortical Insufficiency: Occurrence in Patients Previously Treated with Cortisone , J.A.M.A. 152:1509-1515 ( (Aug. 15) ) 1953. 20. Salassa, R. M.; Keating, F. R., Jr., and Sprague, R. G.: Clinical Aspects of Suppression of Adrenal Cortical Function after Use of Cortisone , Proc. Staff Meet. Mayo Clin. 28:662-668 ( (Nov. 18) ) 1953.

Journal

Archives of Internal Medicine – American Medical Association

Published: Jan 1, 1961

There are no references for this article.