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Effect of Intravenous Fat Emulsions on Human Blood Viscosity

Effect of Intravenous Fat Emulsions on Human Blood Viscosity Abstract Because intravenous fat emulsions are now frequently employed as nutritional supplements and because a relationship between increased viscosity and thrombosis has been suggested,1 it appeared important to determine whether these substances increase blood viscosity in human beings. Swank 2 has demonstrated marked changes in the viscosity of blood following intravenous administration of lipids to dogs and after ingestion of large quantities of fat by hamsters.3 His studies were not extended to man. In order to assess the effect of injected fat emulsions on the viscosity of circulating blood, an in vivo technique of measuring viscosity 4 was utilized. Method The method of determining blood viscosity employed in the present study is based on Poiseuille's law that during laminar flow of a homogeneous fluid in a tube of constant diameter the frictional loss bears a linear relationship to the volumetric rate of flow and is independent of the vessel References 1. Schneider, R. A.: Recurrent Thrombophlebitis: An Experimental Study of Life Situations and Emotions and the Clotting Time and Relative Viscosity of the Blood , Am. J.M. Sc. 222:562, 1951.Crossref 2. Swank, R. L.: Effects of Fat on Blood Viscosity in Dogs , Circulation Res. 4:579, 1956.Crossref 3. Swank, R. L.: Effect of High Fat Feedings on Viscosity of the Blood , Science 120:427, 1954.Crossref 4. Pirofsky, B.: The Determination of Blood Viscosity in Man by a Method Based on Poiseuille's Law , J. Clin. Invest. 32:292, 1953.Crossref 5. Gousios, A., and Shearn, M. A.: Effect of Intravenous Heparin on Human Blood Viscosity , Circulation 20:1063, 1959.Crossref 6. Meyer, C. E.; Fancher, J. A.; Schurr, P. E., and Webster, H. D.: Composition, Preparation and Testing of an Intravenous Fat Emulsion , Metabolism 6:591, 1957. 7. Green, H. D.: Circulatory System: Physical Principles , in Medical Physics , Glasser, O., Editor: Chicago, Year Book Publishers, Inc., 1950, Vol. II, p. 243. 8. Stacy, R. W.; Williams, D. T.; Worden, R. E., and McMorris, R. O.: Essentials of Biological and Medical Physics , New York, McGraw-Hill Book Company, Inc., 1955, p. 367. 9. Fishberg, E. H.: The Significance of Changes of Viscosity in Pathological Sera , J. Biol. Chem. 85:465, 1930. 10. Watson, W. C.: Lipaemia, Heparin, and Blood Viscosity , Lancet 273:366, 1957.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Effect of Intravenous Fat Emulsions on Human Blood Viscosity

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1960.03820050031006
Publisher site
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Abstract

Abstract Because intravenous fat emulsions are now frequently employed as nutritional supplements and because a relationship between increased viscosity and thrombosis has been suggested,1 it appeared important to determine whether these substances increase blood viscosity in human beings. Swank 2 has demonstrated marked changes in the viscosity of blood following intravenous administration of lipids to dogs and after ingestion of large quantities of fat by hamsters.3 His studies were not extended to man. In order to assess the effect of injected fat emulsions on the viscosity of circulating blood, an in vivo technique of measuring viscosity 4 was utilized. Method The method of determining blood viscosity employed in the present study is based on Poiseuille's law that during laminar flow of a homogeneous fluid in a tube of constant diameter the frictional loss bears a linear relationship to the volumetric rate of flow and is independent of the vessel References 1. Schneider, R. A.: Recurrent Thrombophlebitis: An Experimental Study of Life Situations and Emotions and the Clotting Time and Relative Viscosity of the Blood , Am. J.M. Sc. 222:562, 1951.Crossref 2. Swank, R. L.: Effects of Fat on Blood Viscosity in Dogs , Circulation Res. 4:579, 1956.Crossref 3. Swank, R. L.: Effect of High Fat Feedings on Viscosity of the Blood , Science 120:427, 1954.Crossref 4. Pirofsky, B.: The Determination of Blood Viscosity in Man by a Method Based on Poiseuille's Law , J. Clin. Invest. 32:292, 1953.Crossref 5. Gousios, A., and Shearn, M. A.: Effect of Intravenous Heparin on Human Blood Viscosity , Circulation 20:1063, 1959.Crossref 6. Meyer, C. E.; Fancher, J. A.; Schurr, P. E., and Webster, H. D.: Composition, Preparation and Testing of an Intravenous Fat Emulsion , Metabolism 6:591, 1957. 7. Green, H. D.: Circulatory System: Physical Principles , in Medical Physics , Glasser, O., Editor: Chicago, Year Book Publishers, Inc., 1950, Vol. II, p. 243. 8. Stacy, R. W.; Williams, D. T.; Worden, R. E., and McMorris, R. O.: Essentials of Biological and Medical Physics , New York, McGraw-Hill Book Company, Inc., 1955, p. 367. 9. Fishberg, E. H.: The Significance of Changes of Viscosity in Pathological Sera , J. Biol. Chem. 85:465, 1930. 10. Watson, W. C.: Lipaemia, Heparin, and Blood Viscosity , Lancet 273:366, 1957.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Nov 1, 1960

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