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A. Sjoerdsma, L. Gillespie, S. Udenfriend (1958)
A SIMPLE METHOD FOR THE MEASUREMENT OF MONOAMINE-OXIDASE INHIBITION IN MANThe Lancet, 272
S. Udenfriend, E. Titus, H. Weissbach, R. Peterson (1956)
Biogenesis and metabolism of 5-hydroxyindole compounds.The Journal of biological chemistry, 219 1
S. Udenfriend, E. Titus, H. Weissbach (1955)
The identification of 5-hydroxy-3-indoleacetic acid in normal urine and a method for its assay.The Journal of biological chemistry, 216 2
Thorson Ah (1958)
Studies on carcinoid disease.Acta Medica Scandinavica, 334
B. Twarog, I. Page (1953)
Serotonin content of some mammalian tissues and urine and a method for its determination.The American journal of physiology, 175 1
C. Clark, H. Weissbach, S. Udenfriend (1954)
5-Hydroxytryptophan decarboxylase: preparation and properties.The Journal of biological chemistry, 210 1
S. Udenfriend, H. Weissbach, D. Bogdanski (1957)
Increase in tissue serotonin following administration of its precursor 5-hydroxytryptophan.The Journal of biological chemistry, 224 2
T. Waalkes, A. Sjoerdsma, C. Creveling, H. Weissbach, S. Udenfriend (1958)
Serotonin, norepinephrine, and related compounds in bananas.Science, 127 3299
L. Fiore-donati, V. Erspamer (1957)
Studies on the nephrotoxicity of 5-hydroxytryptamine (enteramine) in the rat.The American journal of pathology, 33 5
A. Sjoerdsma, H. Weissbach, L. Terry, S. Udenfriend (1957)
Further observations on patients with malignant carcinoid.The American journal of medicine, 23 1
R. Macdonald, S. Robbins, G. Mallory (1958)
Dermal Fibrosis Following Subcutaneous Injections of Serotonin Creatinine Sulphate.∗Proceedings of the Society for Experimental Biology and Medicine, 97
V. Erspamer (1954)
Pharmacology of IndolalkylaminesPharmacol. Rev., 6
E. Bülbring, R. Lin (1958)
The effect of intraluminal application of 5‐hydroxytryptamine and 5‐hydroxytryptophan on peristalsis; the local production of 5‐HT and its release in relation to intraluminal pressure and propulsive activityThe Journal of Physiology, 140
G. Born, G. Ingram, R. Stacey (1957)
The proportionality between the amounts of 5-hydroxytryptamine and adenosine triphosphate in blood platelets.The Journal of physiology, 135 2
J. Anderson, M. Ziegler, D. Doeden (1958)
Banana feeding and urinary excretion of 5-hydroxyindoleacetic acid.Science, 127 3292
D. Bogdanski, A. Pletscher, B. Brodie, S. Udenfriend (1956)
Identification and assay of serotonin in brain.The Journal of pharmacology and experimental therapeutics, 117 1
A. Sjoerdsma, H. Weissbach, S. Udenfriend (1955)
SIMPLE TEST FOR DIAGNOSIS OF METASTATIC CARCINOID (ARGENTAFFINOMA)JAMA, 159
C. E. Dalgliesh (1957)
On the Site of Formation of 5-HydroxytryptophanBiochem. J., 65
V. Erspamer (1954)
Observations on the Metabolism of Endogenous 5-Hydroxytryptamine (Enteramine) in the RatExperientia, 10
W. McIsaac, I. Page (1958)
New metabolites of serotonin in carcinoid urine.Science, 128 3323
S. Udenfriend (1954)
Studies on Serotonin (5-Hydroxytryptamine) in PlateletsFed. Proc., 13
R. Donaldson, S. Gray (1959)
The urinary excretion of 5-hydroxyindoleacetic acid after the administration of serotonin precursor in patients with hepatic cirrhosis.Gastroenterology, 36 1
H. Weissbach, B. Redfield, S. Udenfriend (1957)
Soluble monoamine oxidase; its properties and actions on serotonin.The Journal of biological chemistry, 229 2
H. Weissbach, D. Bogdanski, B. Redfield, S. Udenfriend (1957)
Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation.The Journal of biological chemistry, 227 2
M. Sandler, P.J.D. Snow (1958)
An atypical carcinoid tumour secreting 5-hydroxytryptophan.Lancet, 1 7012
F. Borges, S. Bessman (1956)
Urinary Excretion of 5-Hydroxyindole Acetic Acid, A Serotonin Metabolite, in Hypertensive Renal-Vascular Disease.∗Proceedings of the Society for Experimental Biology and Medicine, 93
M. Hayashi, K. Ogata, T. Shiraogawa, O. Kawase (1958)
β-Glucuronidase, Lipase and Esterase in the Testis of the Cryptorchid RatNature, 181
I. H. Page (1958)
Serotonin (5-Hydroxytryptamine): The Last 4 YearsPhysiol. Rev., 38
A. Michelson, W. Hollander, F. Lowell (1958)
The effect of 5-hydroxytryptamine (serotonin) on the respiration on nonasthmatic and asthmatic subjects. I.The Journal of laboratory and clinical medicine, 51 1
A. Sjoerdsma (1955)
Studies on Indole Metabolism in Patients with Malignant Carcinoid (Argentaffinoma)J. Clin. Invest., 34
Davidson Jd, Albert Sjoerdsma, L. Loomis, Sidney Udenfriend (1957)
Studies with the serotonin precursor, 5-hydroxytryptophan, in experimental animals and man.The Journal of clinical investigation, 36 11
Sachchidananda Banerjee, P. Agarwal (1958)
Tryptophan-Nicotinic Acid Metabolism in SchizophreniaProceedings of the Society for Experimental Biology and Medicine, 97
A. Todrick, M. Dick, A. Tait (1958)
Effect of Reserpine in Therapeutic Dosage on Excretion of 5-Hydroxyindoleacetic AcidBritish Medical Journal, 1
H. Weissbach , B. G. Redfield (1958)
Serotonin-o-Glucuronide: An Alternate Route of Serotonin MetabolismFed. Proc., 17
C. Pare, M. Sandler, R. Stacey (1957)
5-Hydroxytryptamine deficiency in phenylketonuria.Lancet, 272 6968
B. T. Chadwick (1958)
The Formation of 5-Hydroxytryptamine-o-Sulphate by Rat-Liver HomogenatesBiochem. J., 68
A. Sjoerdsma, T. Smith, T. Stevenson, S. Udenfriend (1955)
Metabolism of 5-Hydroxytryptamine (Serotonin) by Monoamine Oxidase.∗Proceedings of the Society for Experimental Biology and Medicine, 89
J. Parratt, G. West (1957)
5‐hydroxytryptamine and tissue mast cellsThe Journal of Physiology, 137
Mckusick Va (1956)
Carcinoid cardiovascular disease.Bulletin of the Johns Hopkins Hospital, 98
D. Lagunoff , K. B. Lam, E. Roeper (1957)
5-Hydroxytryptamine Formation from 5-Hydroxytryptophan by Mast CellsFed. Proc., 16
A. Davison, M. Sandler (1958)
Inhibition of 5-Hydroxytryptophan Decarboxylase by Phenylalanine MetabolitesNature, 181
A. Feldstein, H. Hoagland, H. Freeman (1958)
On the relationship of serotonin to schizophrenia.Science, 128 3320
C. Mitoma, H. Weissbach, S. Udenfriend (1956)
5-Hydroxytryptophan formation and tryptophan metabolism in Chromobacterium violaceum.Archives of biochemistry and biophysics, 63 1
A. Davison (1958)
Physiological role of monoamine oxidase.Physiological reviews, 38 4
B. Haverback, John Davidson (1958)
Serotonin and the gastrointestinal tract.Gastroenterology, 35 6
Olson Te, Gray Sj (1958)
Serotonin and gastroenterology.The American Journal of Gastroenterology, 29
G. Ross, I. Weinstein, B. Kabakow (1958)
The influence of phenothiazine and some of its derivatives on the determination of 5-hydroxyindoleacetic acid in urine.Clinical chemistry, 4 1
C. Porter, D. Titus, B. Sanders, E. Smith (1957)
Oxidation of serotonin in the presence of ceruloplasmin.Science, 126 3281
K. Freter , H. Weissbach, S. Udenfriend (1957)
Biochemical and Pharmacological Studies with D- and L-5-HydroxytryptophanProc. Soc. Exper. Biol. & Chem., 94
B. B. Brodie (1958)
Storage and Release of 5-Hydroxytryptamine—Possible Significance in Chemical Mediation in Brain, in 5-Hydroxytryptamine
T. Hendrix, M. Atkinson, J. Clifton, F. Ingelfinger (1957)
The effect of 5-hydroxytryptamine on intestinal motor function in man.The American journal of medicine, 23 6
Parkhurst Shore, S. Silver, Bernard Brodie (1955)
Interaction of reserpine, serotonin, and lysergic acid diethylamide in brain.Science, 122 3163
J. Buzard, P. Nytch (1957)
The relation of dietary pyridoxine to the 5-hydroxytryptophan decarboxylase activity of rat kidney.The Journal of biological chemistry, 229 1
Kurt Freter, H. Weissbach, S. Udenfriend, B. Witkop (1957)
Biochemical and Pharmacological Studies with d- and l-5-HydroxytryptophanProceedings of the Society for Experimental Biology and Medicine, 94
S. Bessman, J. Merlis, F. Borges (1957)
Effect of 5-Hydroxytryptophane Upon Electroencephalogram in Hepatic Coma.∗Proceedings of the Society for Experimental Biology and Medicine, 95
O. Kowlessar, R. Williams, D. Law, M. Sleisenger (1958)
Urinary excretion of 5-hydroxyindolacetic acid in diarrheal states, with special reference to nontropical sprue.The New England journal of medicine, 259 7
Albert Sjoerdsma, T. Waalkes, Herbert Weissbach (1957)
Serotonin and histamine in mast cells.Science, 125 3259
T. Waalkes, H. Weissbach, J. Bozicevich, S. Udenfriend (1957)
Serotonin and histamine release during anaphylaxis in the rabbit.The Journal of clinical investigation, 36 7
H. Weissbach, T. Waalkes, S. Udenfriend (1957)
Presence of serotonin in lung and its implication in the anaphylactic reaction.Science, 125 3241
Abstract The presence of a vasopressor factor in clotted defibrinated blood has been known for 90 years. This factor, serotonin, was isolated from blood platelets and identified as 5-hydroxytryptamine in 1948, by Rapport. In 1937, enteramine, a smooth muscle constrictor which was later found to be identical with serotonin, was isolated from intestinal mucosa by Erspamer. He suggested that enteramine was a hormonal substance secreted by the argentaffin cells of the intestine. Intense interest in this entire subject was stimulated by recognition of the disease entity, malignant carcinoidosis. The syndrome is caused by malignant carcinoid tumors (argentaffinomas), which contain large quantities of serotonin. Patients with carcinoidosis have increased amounts of serotonin in the blood and large quantities of 5-hydroxyindoleacetic acid, the major metabolite of serotonin, in the urine. The clinical features of the carcinoid syndrome include episodic flushing of the skin, patchy cyanosis, telangiectasia, pellagra-like skin lesions, bronchoconstriction, edema, atypical valvular References 1. Page, I. H.: Serotonin (5-Hydroxytryptamine): The Last 4 Years , Physiol. Rev. 38:277, 1958. 2. Thorson, A. H.: Studies on Carcinoid Disease , Acta med. scandinav. ( (Supp. 334) ) 161:1, 1958. 3. Udenfriend, S.; Titus, E.; Weissbach, H., and Peterson, R. E.: Biogenesis and Metabolism of 5-Hydroxyindole Compounds , J. Biol. Chem. 219:335, 1956. 4. Udenfriend, S.; Weissbach, H., and Bogdanski, D. F.: Increase in Tissue Serotonin Following Administration of Its Precursor 5-Hydroxytryptophan , J. Biol. Chem. 224:803, 1957. 5. Clark, C. T.; Weissbach, H., and Udenfriend, S.: 5-Hydroxytryptophan Decarboxylase: Preparation and Properties , J. Biol. Chem. 210:139, 1954. 6. Sjoerdsma, A.; Smith, T. E.; Stevenson, T. 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N.: Physiological Role of Monoamine Oxidase , Physiol. Rev. 38:729, 1958. 44. McKusick, V. A.: Carcinoid Cardiovascular Disease , Bull. Johns Hopkins Hosp. 98:13, 1956. 45. Sjoerdsma, A.; Gillespie, L., Jr., and Udenfriend, S. A Simple Method for the Measurement of Monoamine-Oxidase Inhibition in Man , Lancet 2:159, 1958. 46. Sjoerdsma, A.; Weissbach, H., and Udenfriend, S.: Simple Test for Diagnosis of Metastatic Carcinoid (Argentaffinoma) , J. A. M. A. 159:397, 1955. 47. Kowlessarn, O. D.; Williams, R. C.; Law, D. H., and Sleisenger, M. H.: Urinary Excretion of 5-Hydroxyindoleacetic Acid in Diarrheal States, with Special Reference to Nontropical Sprue , New England J. Med. 259:340, 1958. 48. Waalkes, T. P.; Sjoerdsma, A.; Creveling, C. R.; Weissbach, H., and Udenfriend, S.: Serotonin, Norepinephrine, and Related Compounds in Bananas , Science 127:648, 1958. 49. Anderson, J. A.; Ziegler, M. 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A.M.A. Archives of Internal Medicine – American Medical Association
Published: Aug 1, 1959
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