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The Diuretic Response to Administered Water in Patients with Liver Disease: I. Acute Infectious Hepatitis

The Diuretic Response to Administered Water in Patients with Liver Disease: I. Acute Infectious... Abstract The extensive literature concerned with the urinary excretion of water and solute in patients with liver disease has recently been reviewed.1 Although many reports describe impairment of water excretion in acute infectious hepatitis,2-5 there are few observations concerned with the determination of maximal diuretic response to administered water in conjunction with measurement of glomerular filtration rate and solute excretion. Accordingly, the acute renal response to water loading was investigated in ten patients with active viral hepatitis. In all, during the acute phase of the disease, a normal diuretic response to water administration was demonstrated. Material and Methods The patients, men varying in age from 21-34, were studied during the acute phase of viral hepatitis as diagnosed by clinical and laboratory criteria. Certain relevant data concerning the patients are shown in Table 1. Eight of the patients were studied within three days of admission before any improvement in clinical References 1. Papper, S.: The Role of the Kidney in Laennec's Cirrhosis of the Liver , Medicine 37:299-316, 1958.Crossref 2. Von Noorden, C.: Metabolism and Practical Medicine : Vol. 2, Pathology, Chicago, W. T. Keener & Co., 1907, p. 267. 3. Jones, C. M., and Eaton, F. B.: The Prognostic Significance of a Spontaneous Diuresis in Acute or Subacute Disease of the Liver , New England J. Med. 213:907-918,2 1935.Crossref 4. Adlersberg, D., and Fox, C. L., Jr.: Changes of the Water Tolerance Test in Hepatic Disease , Ann. Int. Med. 19:642-650, 1943.Crossref 5. Labby, D. H., and Hoagland, C. L.: Water Storage and the Movements of Body Fluids and Chlorides During Acute Liver Disease , J. Clin. Invest. 26:343-353, 1947.Crossref 6. Strauss, M. B.; Davis, R. K.; Rosenbaum, J. D., and Rossmeisl, E. C.: "Water Diuresis" Produced During Recumbency by the Intravenous Infusion of Isotonic Saline Solution , J. Clin. Invest. 30:862-868, 1951.Crossref 7. Birchard, W. H.; Prout, T. E.; Williams, T. F., and Rosenbaum, J. D.: Diuretic Responses to Oral and Intravenous Water Loads in Patients with Hepatic Cirrhosis , J. Lab. & Clin. Med. 48:26-35, 1956. 8. Rosenbaum, J. D.; Nelson, W. P., III; Strauss, M. B.; Davis, R. K., and Rossmeisl, E. C.: Variation in the Diuretic Response to Ingested Water Related to the Renal Excretion of Solutes , J. Clin. Invest. 32:394-404, 1953. 9. Heintzelmann, F.: Nyrefunktionsundersogelser hos patienter med hepatitis epidemica med henblik paa det hepato-renale syndrome , Nord. med. 33:240, 1947. 10. Farquhar, J. D.: Renal Studies in Acute Infectious (Epidemic) Hepatitis , Am. J. M. Sc. 218: 291-297, 1949. 11. Siegler, P., and Faludi, G.: Nierenfunktionsprüfungen bei Leberkranken , Ztschr. ges. inn. Med. 8:607-611, 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

The Diuretic Response to Administered Water in Patients with Liver Disease: I. Acute Infectious Hepatitis

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1959.00270050068011
Publisher site
See Article on Publisher Site

Abstract

Abstract The extensive literature concerned with the urinary excretion of water and solute in patients with liver disease has recently been reviewed.1 Although many reports describe impairment of water excretion in acute infectious hepatitis,2-5 there are few observations concerned with the determination of maximal diuretic response to administered water in conjunction with measurement of glomerular filtration rate and solute excretion. Accordingly, the acute renal response to water loading was investigated in ten patients with active viral hepatitis. In all, during the acute phase of the disease, a normal diuretic response to water administration was demonstrated. Material and Methods The patients, men varying in age from 21-34, were studied during the acute phase of viral hepatitis as diagnosed by clinical and laboratory criteria. Certain relevant data concerning the patients are shown in Table 1. Eight of the patients were studied within three days of admission before any improvement in clinical References 1. Papper, S.: The Role of the Kidney in Laennec's Cirrhosis of the Liver , Medicine 37:299-316, 1958.Crossref 2. Von Noorden, C.: Metabolism and Practical Medicine : Vol. 2, Pathology, Chicago, W. T. Keener & Co., 1907, p. 267. 3. Jones, C. M., and Eaton, F. B.: The Prognostic Significance of a Spontaneous Diuresis in Acute or Subacute Disease of the Liver , New England J. Med. 213:907-918,2 1935.Crossref 4. Adlersberg, D., and Fox, C. L., Jr.: Changes of the Water Tolerance Test in Hepatic Disease , Ann. Int. Med. 19:642-650, 1943.Crossref 5. Labby, D. H., and Hoagland, C. L.: Water Storage and the Movements of Body Fluids and Chlorides During Acute Liver Disease , J. Clin. Invest. 26:343-353, 1947.Crossref 6. Strauss, M. B.; Davis, R. K.; Rosenbaum, J. D., and Rossmeisl, E. C.: "Water Diuresis" Produced During Recumbency by the Intravenous Infusion of Isotonic Saline Solution , J. Clin. Invest. 30:862-868, 1951.Crossref 7. Birchard, W. H.; Prout, T. E.; Williams, T. F., and Rosenbaum, J. D.: Diuretic Responses to Oral and Intravenous Water Loads in Patients with Hepatic Cirrhosis , J. Lab. & Clin. Med. 48:26-35, 1956. 8. Rosenbaum, J. D.; Nelson, W. P., III; Strauss, M. B.; Davis, R. K., and Rossmeisl, E. C.: Variation in the Diuretic Response to Ingested Water Related to the Renal Excretion of Solutes , J. Clin. Invest. 32:394-404, 1953. 9. Heintzelmann, F.: Nyrefunktionsundersogelser hos patienter med hepatitis epidemica med henblik paa det hepato-renale syndrome , Nord. med. 33:240, 1947. 10. Farquhar, J. D.: Renal Studies in Acute Infectious (Epidemic) Hepatitis , Am. J. M. Sc. 218: 291-297, 1949. 11. Siegler, P., and Faludi, G.: Nierenfunktionsprüfungen bei Leberkranken , Ztschr. ges. inn. Med. 8:607-611, 1953.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: May 1, 1959

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