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An Agent Effective Against Cryptococcosis of the Central Nervous System

An Agent Effective Against Cryptococcosis of the Central Nervous System Abstract Introduction In 1950, Mosberg and Arnold reviewed all reported cases of cryptococcosis.1 In summarizing results with more than 25 therapeutic agents, they concluded that "no methods of treatment have proved effective... any encouragement provided by an apparent response to a drug is in most cases nullified by an equally discouraging response when the same drug is employed on another patient."In 1952, Carton2 summarized the approximately 200 reported cases of cryptococcosis with central nervous system involvement with the statement that of the 14 patients alive at the time of their respective reports only 1 could be considered cured. (This patient was well and apparently free of infection six years after treatment with sulfadiazine.3) Carton then summarized the previously reported experiences with cycloheximide (Actidione, Upjohn), including seven fairly well documented cases, by saying "the use of Actidione in the central nervous system disease has been unsatisfactory, except for References 1. Suggested, in response to our inquiry, by Dr. Gavin Hildick-Smith, of the Squibb Institute for Medical Research, and provided by E. R. Squibb & Sons, Division of Olin Mathieson Chemical Corporation. 2. Mosberg, W. H., Jr., and Arnold, J. G., Jr.: Torulosis of the Central Nervous System: Review of Literature and Report of 5 Cases , Ann. Int. Med. 32:1153-1183 ( (June) ) 1950.Crossref 3. Carton, C. A.: Treatment of Central Nervous System Cryptococcosis: A Review and Report of 4 Cases Treated with Actidione , Ann. Int. Med. 37:123-154 ( (July) ) 1952.Crossref 4. Marshall, M., and Teed, R. W.: Torula Histolytica Meningoencephalitis: Further Report , Ann. Int. Med. 34:1277-1279 ( (May) ) 1951.Crossref 5. Boshes, L. D.; Sherman, I. C.; Hesser, C. J.; Milzer, A., and MacLean, H.: Fungus Infections of the Central Nervous System: Experience in Treatment of Cryptococcosis with Cycloheximide (Actidione) , A. M. A. Arch. Neurol. & Psychiat. 75:175-197 ( (Feb.) ) 1956. 6. Gold, W.; Stout, H. A.; Pagano, J. F., and Donovick, R.: Amphotericins A and B, Antifungal Antibiotics Produced by a Streptomycete: I. In Vitro Studies , Antibiotics Ann. , pp. 579-586, 1955-1956. 7. Vandeputte, J.; Wachtel, J. L., and Stiller, E. T.: Amphotericins A and B, Antifungal Anti- biotics Produced by a Streptomycete: II. The Isolation and Properties of the Crystalline Amphotericins , Antibiotics Ann. , pp. 587-591, 1955-1956. 8. Steinberg, B. A.; Jambor, W. P., and Suydam, L. O.: Amphotericins A and B: Two New Antifungal Antibiotics Possessing High Activity Against Deep-Seated and Superficial Mycoses , Antibiotics Ann. , pp. 574-578, 1955-1956. 9. Sternberg, T. H.; Wright, E. T., and Oura, M.: A New Antifungal Antibiotic, Amphotericin B , Antibiotics Ann. , pp. 566-573, 1955-1956. 10. Appelbaum, E., and Shtokalko, S.: Cryptococcus Meningitis Arrested with Amphotericin B , Ann. Int. Med. 47:346-351 ( (Aug.) ) 1957. 11. Rubin, H.; Lehan, P. H., and Furcolow, M. L.: Severe Nonfatal Histoplasmosis: Report of a Typical Case, with Comments on Therapy , New England J. Med. 257:599-602 ( (Sept. 26) ) 1957. 12. Louria, D. B.; Feder, N., and Emmons, C. W.: Amphotericin B in Experimental Histoplasmosis and Cryptococcosis , Antibiotics Ann. , pp. 870-877, 1956-1957. 13. Kozinn, P. J.; Taschdjian, C. L.; Dragutsky, D., and Minsky, A.: Treatment of Cutaneous Candidiasis in Infancy and Childhood with Nystatin and Amphotericin B , Antibiotics Ann. , pp. 128-134, 1956-1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

An Agent Effective Against Cryptococcosis of the Central Nervous System

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1958.00260220117012
Publisher site
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Abstract

Abstract Introduction In 1950, Mosberg and Arnold reviewed all reported cases of cryptococcosis.1 In summarizing results with more than 25 therapeutic agents, they concluded that "no methods of treatment have proved effective... any encouragement provided by an apparent response to a drug is in most cases nullified by an equally discouraging response when the same drug is employed on another patient."In 1952, Carton2 summarized the approximately 200 reported cases of cryptococcosis with central nervous system involvement with the statement that of the 14 patients alive at the time of their respective reports only 1 could be considered cured. (This patient was well and apparently free of infection six years after treatment with sulfadiazine.3) Carton then summarized the previously reported experiences with cycloheximide (Actidione, Upjohn), including seven fairly well documented cases, by saying "the use of Actidione in the central nervous system disease has been unsatisfactory, except for References 1. Suggested, in response to our inquiry, by Dr. Gavin Hildick-Smith, of the Squibb Institute for Medical Research, and provided by E. R. Squibb & Sons, Division of Olin Mathieson Chemical Corporation. 2. Mosberg, W. H., Jr., and Arnold, J. G., Jr.: Torulosis of the Central Nervous System: Review of Literature and Report of 5 Cases , Ann. Int. Med. 32:1153-1183 ( (June) ) 1950.Crossref 3. Carton, C. A.: Treatment of Central Nervous System Cryptococcosis: A Review and Report of 4 Cases Treated with Actidione , Ann. Int. Med. 37:123-154 ( (July) ) 1952.Crossref 4. Marshall, M., and Teed, R. W.: Torula Histolytica Meningoencephalitis: Further Report , Ann. Int. Med. 34:1277-1279 ( (May) ) 1951.Crossref 5. Boshes, L. D.; Sherman, I. C.; Hesser, C. J.; Milzer, A., and MacLean, H.: Fungus Infections of the Central Nervous System: Experience in Treatment of Cryptococcosis with Cycloheximide (Actidione) , A. M. A. Arch. Neurol. & Psychiat. 75:175-197 ( (Feb.) ) 1956. 6. Gold, W.; Stout, H. A.; Pagano, J. F., and Donovick, R.: Amphotericins A and B, Antifungal Antibiotics Produced by a Streptomycete: I. In Vitro Studies , Antibiotics Ann. , pp. 579-586, 1955-1956. 7. Vandeputte, J.; Wachtel, J. L., and Stiller, E. T.: Amphotericins A and B, Antifungal Anti- biotics Produced by a Streptomycete: II. The Isolation and Properties of the Crystalline Amphotericins , Antibiotics Ann. , pp. 587-591, 1955-1956. 8. Steinberg, B. A.; Jambor, W. P., and Suydam, L. O.: Amphotericins A and B: Two New Antifungal Antibiotics Possessing High Activity Against Deep-Seated and Superficial Mycoses , Antibiotics Ann. , pp. 574-578, 1955-1956. 9. Sternberg, T. H.; Wright, E. T., and Oura, M.: A New Antifungal Antibiotic, Amphotericin B , Antibiotics Ann. , pp. 566-573, 1955-1956. 10. Appelbaum, E., and Shtokalko, S.: Cryptococcus Meningitis Arrested with Amphotericin B , Ann. Int. Med. 47:346-351 ( (Aug.) ) 1957. 11. Rubin, H.; Lehan, P. H., and Furcolow, M. L.: Severe Nonfatal Histoplasmosis: Report of a Typical Case, with Comments on Therapy , New England J. Med. 257:599-602 ( (Sept. 26) ) 1957. 12. Louria, D. B.; Feder, N., and Emmons, C. W.: Amphotericin B in Experimental Histoplasmosis and Cryptococcosis , Antibiotics Ann. , pp. 870-877, 1956-1957. 13. Kozinn, P. J.; Taschdjian, C. L.; Dragutsky, D., and Minsky, A.: Treatment of Cutaneous Candidiasis in Infancy and Childhood with Nystatin and Amphotericin B , Antibiotics Ann. , pp. 128-134, 1956-1957.

Journal

A.M.A. Archives of Internal Medicine – American Medical Association

Published: Nov 1, 1958

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