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Fibrinolysis and Changes in Fibrinogen in Multiple Myeloma

Fibrinolysis and Changes in Fibrinogen in Multiple Myeloma Abstract Fibrinolysis has been described in a variety of disturbances. An excellent historical review and discussion of fibrinolysis was published in 1948, by Macfarlane and Biggs.1 A complete analytical review of fibrinolysis by Astrup appeared in 1956.2 Acute fibrinolysis has been observed in severe trauma, shock, hemorrhages, burns, and transfusion reactions and following surgical procedures on the lung, uterus, and pancreas.3-5 Acute fibrinolysis also has followed premature separation of the placenta and other obstetric accidents. In other cases fibrinolytic activity may be chronic, proceeding slowly, as in the patients described in this paper. Such chronic fibrinolysis has been described in acute leukemia,6 cirrhosis of the liver,7 a significant percentage of patients with carcinoma of the prostate,8-10 and rarely in patients suffering from disseminated cancer of the bladder, stomach, breast, etc.3,11 True fibrinolysis was observed in one case of multiple myeloma and in one probable case of disseminated lupus erythematosus by Waldenström.12 References 1. Macfarlane, R. G., and Biggs, R.: Fibrinolysis: Its Mechanism and Significance , Blood 3:1167-1187 ( (Oct.) ) 1948. 2. Astrup, T.: Fibrinolysis in the Organism , Blood 11:781-806 ( (Sept.) ) 1956. 3. Coon, W. W., and Hodgson, P. E.: Fibrinolysis in Surgery Patients: Possible Relationship to Hemorrhagic Diathesis , Surg. Gynec. & Obst. 95: 717-724 ( (Dec.) ) 1952. 4. Tagnon, H. J.; Levenson, S. M.; Davidson, C. S., and Taylor, F. H. L.: Occurrence of Fibrinolysis in Shock, with Observations on the Prothrombin Time and the Plasma Fibrinogen During Hemorrhagic Shock , Am. J. M. Sc. 211: 88-96 ( (Jan.) ) 1946. 5. Crosby, W. H., and Stefanini, M.: Pathogenesis of the Plasma Transfusion Reaction with Especial Reference to the Blood Coagulation System , J. Lab. & Clin. Med. 40:374-386 ( (Sept.) ) 1952. 6. Cooperberg, A. A., and Neiman, G. M. A.: Fibrinogenopenia and Fibrinolysis in Acute Myelogenous Leukemia , Ann. Int. Med. 42:706-711 ( (March) ) 1955. 7. Harrington, W. J.; Manheimer, R. H.; Desforges, J. F.; Minkel, H. P.; Crow, C. B., and Stohlman, F.: The Bleeding Tendency in Hepatocellular and Obstructive Jaundice , Bull. New England M. Center 12:121-128 ( (June) ) 1950. 8. Tagnon, H. J.; Schulman, P.; Whitmore, W. F., Jr., and Leone, L. A.: Prostatic Fibrinolysin: Study of a Case Illustrating Role in Hemorrhagic Diathesis of Cancer of the Prostate , Am. J. Med. 15:875-884 ( (Dec.) ) 1953. 9. Tagnon, H. J.; Whitmore, W. F., Jr., and Shulman, N. R.: Fibrinolysis in Metastatic Cancer of the Prostate , Cancer 5:9-12 ( (Jan.) ) 1952. 10. Prout, G. R.; Siegel, M.; Cliffton, E. E., and Whitmore, W. F., Jr.: Hemorrhagic Diathesis in Patients with Carcinoma of Prostate , J. A. M. A. 160:840-846 ( (March 10) ) 1956. 11. Dillard, G. H. L., and Chanutin, A.: The Protease and Antiprotease of Plasmas of Patients with Cancer and Other Diseases , Cancer Res. 9:665-668 ( (Nov.) ) 1949. 12. Waldenström, J.: Abnormal Proteins in Myeloma , Advances Int. Med. 5:398-440, 1952. 13. Huggins, C., and Vail, V. C.: Plasma Coagulation and Fibrinogenolysis by Prostatic Fluid and Trypsin , Am. J. Physiol. 139:129-134 ( (May) ) 1943. 14. Kaplan, E. H.: Action of Fibrinolysin (Plasmin) on Proteins , Proc. Soc. Exper. Biol. & Med. 85:142-144 ( (Jan.) ) 1954. 15. Stefanini, M., and Dameshek, W.: The Hemorrhagic Disorders: A Clinical and Therapeutic Approach , New York, Grune & Stratton, Inc., 1955. 16. Craddock, C. G., Jr.; Adams, W. S., and Figueroa, W. G.: Interference with Fibrin Formation in Multiple Myeloma by an Unusual Protein Found in Blood and Urine , J. Lab. & Clin. Med. 42:847-859 ( (Dec.) ) 1953. 17. Lüscher, E., and Labhart, A.: Blutgerinnungsstörung durch βγ-Globuline; Zur Kenntnis der Gerinnungsstörungen durch körpereigene Antikoagulantien , Schweiz. med. Wchnschr. 79:598-604 ( (July 2) ) 1949. 18. Uehlinger, E.: Über eine Blutgerinnungsstörung bei Dysproteinämie (Beitrag zur Kenntnis der körpereigenen Antikoagulantia) , Helvet. med. acta 16:508-528 ( (Nov.) ) 1949. 19. Bull, H. B.: Physical Biochemistry , New York, John Wiley & Sons, Inc., 1943, p. 76. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

Fibrinolysis and Changes in Fibrinogen in Multiple Myeloma

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1958.00260150118015
Publisher site
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Abstract

Abstract Fibrinolysis has been described in a variety of disturbances. An excellent historical review and discussion of fibrinolysis was published in 1948, by Macfarlane and Biggs.1 A complete analytical review of fibrinolysis by Astrup appeared in 1956.2 Acute fibrinolysis has been observed in severe trauma, shock, hemorrhages, burns, and transfusion reactions and following surgical procedures on the lung, uterus, and pancreas.3-5 Acute fibrinolysis also has followed premature separation of the placenta and other obstetric accidents. In other cases fibrinolytic activity may be chronic, proceeding slowly, as in the patients described in this paper. Such chronic fibrinolysis has been described in acute leukemia,6 cirrhosis of the liver,7 a significant percentage of patients with carcinoma of the prostate,8-10 and rarely in patients suffering from disseminated cancer of the bladder, stomach, breast, etc.3,11 True fibrinolysis was observed in one case of multiple myeloma and in one probable case of disseminated lupus erythematosus by Waldenström.12 References 1. Macfarlane, R. G., and Biggs, R.: Fibrinolysis: Its Mechanism and Significance , Blood 3:1167-1187 ( (Oct.) ) 1948. 2. Astrup, T.: Fibrinolysis in the Organism , Blood 11:781-806 ( (Sept.) ) 1956. 3. Coon, W. W., and Hodgson, P. E.: Fibrinolysis in Surgery Patients: Possible Relationship to Hemorrhagic Diathesis , Surg. Gynec. & Obst. 95: 717-724 ( (Dec.) ) 1952. 4. Tagnon, H. J.; Levenson, S. M.; Davidson, C. S., and Taylor, F. H. L.: Occurrence of Fibrinolysis in Shock, with Observations on the Prothrombin Time and the Plasma Fibrinogen During Hemorrhagic Shock , Am. J. M. Sc. 211: 88-96 ( (Jan.) ) 1946. 5. Crosby, W. H., and Stefanini, M.: Pathogenesis of the Plasma Transfusion Reaction with Especial Reference to the Blood Coagulation System , J. Lab. & Clin. Med. 40:374-386 ( (Sept.) ) 1952. 6. Cooperberg, A. A., and Neiman, G. M. A.: Fibrinogenopenia and Fibrinolysis in Acute Myelogenous Leukemia , Ann. Int. Med. 42:706-711 ( (March) ) 1955. 7. Harrington, W. J.; Manheimer, R. H.; Desforges, J. F.; Minkel, H. P.; Crow, C. B., and Stohlman, F.: The Bleeding Tendency in Hepatocellular and Obstructive Jaundice , Bull. New England M. Center 12:121-128 ( (June) ) 1950. 8. Tagnon, H. J.; Schulman, P.; Whitmore, W. F., Jr., and Leone, L. A.: Prostatic Fibrinolysin: Study of a Case Illustrating Role in Hemorrhagic Diathesis of Cancer of the Prostate , Am. J. Med. 15:875-884 ( (Dec.) ) 1953. 9. Tagnon, H. J.; Whitmore, W. F., Jr., and Shulman, N. R.: Fibrinolysis in Metastatic Cancer of the Prostate , Cancer 5:9-12 ( (Jan.) ) 1952. 10. Prout, G. R.; Siegel, M.; Cliffton, E. E., and Whitmore, W. F., Jr.: Hemorrhagic Diathesis in Patients with Carcinoma of Prostate , J. A. M. A. 160:840-846 ( (March 10) ) 1956. 11. Dillard, G. H. L., and Chanutin, A.: The Protease and Antiprotease of Plasmas of Patients with Cancer and Other Diseases , Cancer Res. 9:665-668 ( (Nov.) ) 1949. 12. Waldenström, J.: Abnormal Proteins in Myeloma , Advances Int. Med. 5:398-440, 1952. 13. Huggins, C., and Vail, V. C.: Plasma Coagulation and Fibrinogenolysis by Prostatic Fluid and Trypsin , Am. J. Physiol. 139:129-134 ( (May) ) 1943. 14. Kaplan, E. H.: Action of Fibrinolysin (Plasmin) on Proteins , Proc. Soc. Exper. Biol. & Med. 85:142-144 ( (Jan.) ) 1954. 15. Stefanini, M., and Dameshek, W.: The Hemorrhagic Disorders: A Clinical and Therapeutic Approach , New York, Grune & Stratton, Inc., 1955. 16. Craddock, C. G., Jr.; Adams, W. S., and Figueroa, W. G.: Interference with Fibrin Formation in Multiple Myeloma by an Unusual Protein Found in Blood and Urine , J. Lab. & Clin. Med. 42:847-859 ( (Dec.) ) 1953. 17. Lüscher, E., and Labhart, A.: Blutgerinnungsstörung durch βγ-Globuline; Zur Kenntnis der Gerinnungsstörungen durch körpereigene Antikoagulantien , Schweiz. med. Wchnschr. 79:598-604 ( (July 2) ) 1949. 18. Uehlinger, E.: Über eine Blutgerinnungsstörung bei Dysproteinämie (Beitrag zur Kenntnis der körpereigenen Antikoagulantia) , Helvet. med. acta 16:508-528 ( (Nov.) ) 1949. 19. Bull, H. B.: Physical Biochemistry , New York, John Wiley & Sons, Inc., 1943, p. 76.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1958

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