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Treatment of Staphylococcic Endocarditis: Report of Seven Cases

Treatment of Staphylococcic Endocarditis: Report of Seven Cases Abstract Staphylococcic endocarditis is a difficult and frustrating therapeutic problem. The increasing number of penicillin-resistant strains,1-4 the development of resistance during the course of therapy, and the fulminating and destructive nature of many staphylococcic infections combine to present the physician with an enormously difficult problem in clinical therapeutics. While at one time the Staphylococcus was responsible for only 9.5% of all cases of bacterial endocarditis,5 Dowling2 feels that the staphylococcic is now second in frequency only to the streptococcic type. Results of treatment have not been encouraging. In 1948, Guest and Harrison7 were able to find but 12 instances of successful treatment of endocarditis due to Staphylococcus. Levinson, in 1950, reported 18 patients, with a mortality rate of 66%.1 Dowling,2 in 1952, reported 25 cases treated by penicillin, with a recovery rate of 52%. Fisher et al.8 reported bacteriologic cure of 7 of 13 cases, or 54% survival. The type and References 1. Reported with permission of the Editor of the New England Journal of Medicine. 2. Levinson, D. C.; Griffith, G. C., and Pearson, H. E.: Increasing Bacterial Resistance to the Antibiotics: Study of 46 Cases of Streptococcus Endocarditis and 18 Cases of Staphylococcus Endocarditis , Circulation 2:668-675, 1950.Crossref 3. Dowling, H. F.; Lepper, M.; Caldwell, E. R., and Spies, H. W.: Staphylococcic Endicarditis: An Analysis of 25 Cases Treated with Antibiotics, Together with a Review of the Recent Literature , Medicine 31:155-176, 1952.Crossref 4. Plough, H. H.: Penicillin Resistance of Staphylococcus Aureus and Its Clinical Implications , Am. J. Clin. Path. 15:446-451, 1945. 5. Barber, M., and Rozwadowska-Dowzenko, M.: Infection by Penicillin-Resistant Staphylococci , Lancet 2:641-644, 1948.Crossref 6. Thayer, W. S.: Bacterial or Infective Endocarditis , Edinburgh M. J. 38:237-265, 1931. 7. Beigelman, P. M., and Rantz, L. A.: The Clinical Importance of Coagulase-Positive, Penicillin-Resistant Staphylococcus Aureus , New England J. Med. 242:353-358, 1950.Crossref 8. Guest, C. M., and Harrison, F. F.: Acute Endocarditis Due to Staphylococcus Aureus Sucessfully Treated with Penicillin , Am. J. Med. 5:908-911, 1948.Crossref 9. Fisher, A. M.; Wagner, H. N., and Ross, R. A.: Some Clinical and Therapeutic Observations of 38 Cases of Staphylococcal Endocarditis , Tr. Am. Clin. & Climatol. A. 66:158-169, 1955. 10. Hoyt, R. E., and Bissell, F. E.: Staphylococcus Aureus Endocarditis , California & West. Med. 63:226-227, 1945. 11. Friedberg, C. K., and Bader, M. E.: Acute Staphylococcic Endocarditis Cured with Aid of Bacitracin , J. A. M. A. 147:46-49, 1951. 12. Finland, M.: Treatment of Bacterial Endicarditis: Dosage of Penicillin, Use of Other Antibiotics and Treatment of Patients with Negative Blood Cultures , Circulation 9:292-299, 1954. 13. Bloomfield, A. L.: Diagnosis and Prevention of Bacterial Endocarditis , Circulation 8:290-296, 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

Treatment of Staphylococcic Endocarditis: Report of Seven Cases

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1957.00260040081009
Publisher site
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Abstract

Abstract Staphylococcic endocarditis is a difficult and frustrating therapeutic problem. The increasing number of penicillin-resistant strains,1-4 the development of resistance during the course of therapy, and the fulminating and destructive nature of many staphylococcic infections combine to present the physician with an enormously difficult problem in clinical therapeutics. While at one time the Staphylococcus was responsible for only 9.5% of all cases of bacterial endocarditis,5 Dowling2 feels that the staphylococcic is now second in frequency only to the streptococcic type. Results of treatment have not been encouraging. In 1948, Guest and Harrison7 were able to find but 12 instances of successful treatment of endocarditis due to Staphylococcus. Levinson, in 1950, reported 18 patients, with a mortality rate of 66%.1 Dowling,2 in 1952, reported 25 cases treated by penicillin, with a recovery rate of 52%. Fisher et al.8 reported bacteriologic cure of 7 of 13 cases, or 54% survival. The type and References 1. Reported with permission of the Editor of the New England Journal of Medicine. 2. Levinson, D. C.; Griffith, G. C., and Pearson, H. E.: Increasing Bacterial Resistance to the Antibiotics: Study of 46 Cases of Streptococcus Endocarditis and 18 Cases of Staphylococcus Endocarditis , Circulation 2:668-675, 1950.Crossref 3. Dowling, H. F.; Lepper, M.; Caldwell, E. R., and Spies, H. W.: Staphylococcic Endicarditis: An Analysis of 25 Cases Treated with Antibiotics, Together with a Review of the Recent Literature , Medicine 31:155-176, 1952.Crossref 4. Plough, H. H.: Penicillin Resistance of Staphylococcus Aureus and Its Clinical Implications , Am. J. Clin. Path. 15:446-451, 1945. 5. Barber, M., and Rozwadowska-Dowzenko, M.: Infection by Penicillin-Resistant Staphylococci , Lancet 2:641-644, 1948.Crossref 6. Thayer, W. S.: Bacterial or Infective Endocarditis , Edinburgh M. J. 38:237-265, 1931. 7. Beigelman, P. M., and Rantz, L. A.: The Clinical Importance of Coagulase-Positive, Penicillin-Resistant Staphylococcus Aureus , New England J. Med. 242:353-358, 1950.Crossref 8. Guest, C. M., and Harrison, F. F.: Acute Endocarditis Due to Staphylococcus Aureus Sucessfully Treated with Penicillin , Am. J. Med. 5:908-911, 1948.Crossref 9. Fisher, A. M.; Wagner, H. N., and Ross, R. A.: Some Clinical and Therapeutic Observations of 38 Cases of Staphylococcal Endocarditis , Tr. Am. Clin. & Climatol. A. 66:158-169, 1955. 10. Hoyt, R. E., and Bissell, F. E.: Staphylococcus Aureus Endocarditis , California & West. Med. 63:226-227, 1945. 11. Friedberg, C. K., and Bader, M. E.: Acute Staphylococcic Endocarditis Cured with Aid of Bacitracin , J. A. M. A. 147:46-49, 1951. 12. Finland, M.: Treatment of Bacterial Endicarditis: Dosage of Penicillin, Use of Other Antibiotics and Treatment of Patients with Negative Blood Cultures , Circulation 9:292-299, 1954. 13. Bloomfield, A. L.: Diagnosis and Prevention of Bacterial Endocarditis , Circulation 8:290-296, 1953.

Journal

A.M.A. Archives of Internal Medicine – American Medical Association

Published: Apr 1, 1957

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