Access the full text.
Sign up today, get DeepDyve free for 14 days.
H. Kupperman, J. Epstein (1955)
Oral therapy of adrenal cortical hypofunction; use of combined fluorocortisone acetate and hydrocortisone.Journal of the American Medical Association, 159 15
D. Bergenstal, T. Dao (1953)
Management of Addison's disease in adrenalectomized patients.Bulletin of the New York Academy of Medicine, 29 4
M. Li, J. Rall, J. Maclean, M. Lipsett, B. Ray, O. Pearson (1955)
Thyroid function following hypophysectomy in man.The Journal of clinical endocrinology and metabolism, 15 10
J. P. Maclean , M. C. Li, M. B. Lipsett, B. Ray (1955)
The Physiological Role of Adrenal Salt Hormone (Aldosterone) in ManJ. Clin. Invest., 34
C. Huggins, W. Scott (1945)
Bilateral Adrenalectomy in Prostatic Cancer: Clinical Features and Urinary Excretion of 17-Ketosteroids and Estrogen.Annals of surgery, 122 6
D. Green, J. Nelson, G. Dodds, R. Smalley (1950)
Bilateral adrenalectomy in malignant hypertension and diabetes.Journal of the American Medical Association, 144 6
V. Hollander, C. West, W. Whitmore, H. Randall, O. Pearson (1952)
Physiological effects of bilateral adrenalectomy in manCancer, 5
H. S. Kupperman (1955)
Oral Therapy of Adrenal Cortical Hypo function: Use of Combined Fludrocortisone Acetate and HydrocortisoneJ. A. M. A., 159
D. M. Green , J. N. Nelson, G. A. Dodds (1950)
Bilateral Adrenalectomy in Malignant Hypertension and DiabetesJ. A. M. A., 144
Abstract Bilateral adrenalectomy or hypophysectomy will induce objective remissions in some patients with metastatic breast cancer. It is the purpose of this report to detail our methods for managing patients subjected to these procedures. These methods are based on clinical experience and physiological studies of over 200 patients submitted to either adrenalectomy or hypophysectomy. We shall attempt to describe the general medical management for both procedures and to suggest specific methods for handling the problems peculiar to patients with metastatic disease. Huggins and Scott,1 in 1945, reported the initial experiences with bilateral adrenalectomy in four patients with advanced prostatic cancer. With the use of desoxycorticosterone and adrenal cortical extract they were unable to maintain life in their patients, although one patient survived almost four months. Subsequently, Green and co-workers2 successfully managed adrenalectomy in a diabetic patient with the use of large amounts of adrenal cortical extracts. With the availability References 1. This is given for the first week after operation at this level or 0.1 gm. q. 6 h. P. O. on the advice of our neurosurgical colleagues. 2. Huggins, C., and Scott, W. W.: Bilateral Adrenalectomy in Prostatic Cancer: Clinical Features and Urinary Excretion of 17-Ketosteroids and Estrogen , Ann. Surg. 122:1031, 1945.Crossref 3. Green, D. M.; Nelson, J. N.; Dodds, G. A., and Smalley, R. E.: Bilateral Adrenalectomy in Malignant Hypertension and Diabetes , J. A. M. A. 144:439, 1950.Crossref 4. Bergenstal, D. M., and Dao, T. L. Y.: Management of Addison's Disease in Adrenalectomized Patients , Bull. New York Acad. Med. 29:295, 1953. 5. Hollander, V. P.; West, C. D.; Whitmore, W. F., Jr.; Randall, H. T., and Pearson, O. H.: Physiological Effects of Bilateral Adrenalectomy in Man , Cancer 5:1019, 1952.Crossref 6. Kupperman, H. S., and Epstein, J. A.: Oral Therapy of Adrenal Cortical Hypo function: Use of Combined Fludrocortisone Acetate and Hydrocortisone , J. A. M. A. 159:1447, 1955.Crossref 7. Maclean, J. P.; Li, M. C.; Lipsett, M. B.; Ray, B., and Pearson, O. H.: The Physiological Role of Adrenal Salt Hormone (Aldosterone) in Man , J. Clin. Invest. 34:951, 1955. 8. Li, M. C.; Rall, J. E.; Maclean, J. P.; Lipsett, M. B.; Ray, B. S., and Pearson, O. H.: Thyroid Function Following Hypophysectomy in Man , J. Clin. Endocrinol. 15:1228, 1955.Crossref
A.M.A. Archives of Internal Medicine – American Medical Association
Published: Nov 1, 1956
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.