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REVERSAL OF RENAL INSUFFICIENCY IN GOUT: Report of a Case Treated with Probenecid (Benemid)

REVERSAL OF RENAL INSUFFICIENCY IN GOUT: Report of a Case Treated with Probenecid (Benemid) Abstract RECOGNITION and treatment of reversible disease is the primary function of the physician. This is particularly true when pathological processes involve a vital organ, such as the kidney, where progression of the lesions may lead to functional insufficiency and death. It is the purpose of this paper to review the problem of the renal complications of disturbed uric acid metabolism in gout and to present a case of severe primary gout in a young man with renal insufficiency in whom return to normal renal function occurred during treatment with probenecid (Benemid) over a 34-month period. During this time marked decrease in urate deposits elsewhere besides the kidney occurred, such as visible tophi, and improvement in the state of the clinical gouty arthritis also was seen. It is felt that the observation of the improvement in the renal function of this patient aids in clarifying the pathogenesis of the renal failure References 1. References 3 and 6-10. 2. References 3 and 7. 3. References 3 and 11. 4. References 9 and 10. 5. References 3 and 6. 6. References 5, 10, and 12. 7. Gutman, A. B., and Yu, T. F.: Current Principles of Management in Gout , Am. J. Med. 13:745, 1952.Crossref 8. Talbott, J. H.: Gout and Gouty Arthritis , New York, Grune & Stratton, 1953. 9. Brown, J., and Mallory, G. K.: Renal Changes in Gout , New England J. Med. 243:325, 1950.Crossref 10. Traut, E. F.; Knight, A. A.; Szant, P. B., and Passerelli, E. W.: Specific Vascular Changes in Gout , J. A. M. A. 156:591, 1954.Crossref 11. Talbott, J. H.: Gout , edited by H. A. Christian, reprinted from Oxford Loose-Leaf Medicine , New York, Oxford University Press, 1943, Vol. 4, Chap. 4, p. 79. 12. Spitz, H.; Steinbrocker, O.; Schwartz, S., and Schittone, M.: Fulminating Gout , Am. J. Med. 6:513, 1949.Crossref 13. Schnitker, M. A., and Richter, A. B.: Nephritis in Gout , Am. J. M. Sc. 192:241, 1936.Crossref 14. Bauer, W., and Klemperer, F.: Gout , in Diseases of Metabolism , Ed. 2, Philadelphia, W. B. Saunders Company, 1947, p. 630. 15. Bell, E. T.: Renal Diseases , Ed. 2, Philadelphia, Lea & Febiger, 1950, p. 413. 16. Modern, F. W. S., and Meister, L.: Symposium on Recent Advances in Medicine: The Kidney of Gout, a Clinical Entity , M. Clin. North America , 36:941, 1952. 17. Allen, A. C.: Gout (Distal Nephron Nephrosis) , in The Kidney: Medical and Surgical Diseases , New York, Grune & Stratton, Inc., 1951, p. 286. 18. Coombs, F. S.; Pecora, L.; Thorogood, E.; Consolazio, W., and Talbott, J.: Renal Functions in Patients with Gout , J. Clin. Invest. 19:525, 1940.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

REVERSAL OF RENAL INSUFFICIENCY IN GOUT: Report of a Case Treated with Probenecid (Benemid)

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1955.00250170129020
Publisher site
See Article on Publisher Site

Abstract

Abstract RECOGNITION and treatment of reversible disease is the primary function of the physician. This is particularly true when pathological processes involve a vital organ, such as the kidney, where progression of the lesions may lead to functional insufficiency and death. It is the purpose of this paper to review the problem of the renal complications of disturbed uric acid metabolism in gout and to present a case of severe primary gout in a young man with renal insufficiency in whom return to normal renal function occurred during treatment with probenecid (Benemid) over a 34-month period. During this time marked decrease in urate deposits elsewhere besides the kidney occurred, such as visible tophi, and improvement in the state of the clinical gouty arthritis also was seen. It is felt that the observation of the improvement in the renal function of this patient aids in clarifying the pathogenesis of the renal failure References 1. References 3 and 6-10. 2. References 3 and 7. 3. References 3 and 11. 4. References 9 and 10. 5. References 3 and 6. 6. References 5, 10, and 12. 7. Gutman, A. B., and Yu, T. F.: Current Principles of Management in Gout , Am. J. Med. 13:745, 1952.Crossref 8. Talbott, J. H.: Gout and Gouty Arthritis , New York, Grune & Stratton, 1953. 9. Brown, J., and Mallory, G. K.: Renal Changes in Gout , New England J. Med. 243:325, 1950.Crossref 10. Traut, E. F.; Knight, A. A.; Szant, P. B., and Passerelli, E. W.: Specific Vascular Changes in Gout , J. A. M. A. 156:591, 1954.Crossref 11. Talbott, J. H.: Gout , edited by H. A. Christian, reprinted from Oxford Loose-Leaf Medicine , New York, Oxford University Press, 1943, Vol. 4, Chap. 4, p. 79. 12. Spitz, H.; Steinbrocker, O.; Schwartz, S., and Schittone, M.: Fulminating Gout , Am. J. Med. 6:513, 1949.Crossref 13. Schnitker, M. A., and Richter, A. B.: Nephritis in Gout , Am. J. M. Sc. 192:241, 1936.Crossref 14. Bauer, W., and Klemperer, F.: Gout , in Diseases of Metabolism , Ed. 2, Philadelphia, W. B. Saunders Company, 1947, p. 630. 15. Bell, E. T.: Renal Diseases , Ed. 2, Philadelphia, Lea & Febiger, 1950, p. 413. 16. Modern, F. W. S., and Meister, L.: Symposium on Recent Advances in Medicine: The Kidney of Gout, a Clinical Entity , M. Clin. North America , 36:941, 1952. 17. Allen, A. C.: Gout (Distal Nephron Nephrosis) , in The Kidney: Medical and Surgical Diseases , New York, Grune & Stratton, Inc., 1951, p. 286. 18. Coombs, F. S.; Pecora, L.; Thorogood, E.; Consolazio, W., and Talbott, J.: Renal Functions in Patients with Gout , J. Clin. Invest. 19:525, 1940.Crossref

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Dec 1, 1955

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