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S. Locket, E. Atkinson, W. Grieve (1953)
Histoplasmosis in Great BritainBritish Medical Journal, 2
I. Snapper, L. Mcvay (1953)
The treatment of North American blastomycosis with 2-hydroxystilbamidine.The American journal of medicine, 15 5
R. J. Parsons (1945)
Histoplasmosis in ManArch. Int. Med., 75
I. Snapper, B. Schneid, L. McVay, F. Lieben (1952)
Pharmacology and therapeutic value of diamidine derivatives, particularly of 2-hydroxystilbamidine.Transactions of the New York Academy of Sciences, 14 7
W. Sutliff, J. Kyle, J. Hobson (1954)
North American blastomycosis: clinical forms of the disease and treatment with stilbamidine and 2-hydroxystilbamidine.Annals of internal medicine, 41 1
J. Seabury (1949)
Stilbamidine in the treatment of histoplasmosis; two case reports.Annals of internal medicine, 31 3
F. Ellis, R. Scott, J. Miller (1952)
[Treatment of progressive disseminated histoplasmosis with ethyl vanillate and propamidine].Antibiotics & chemotherapy, 2 7
Amos Christie, James Middleton, J. Peterson, David Mcvickar (1951)
Treatment of disseminated histoplasmosis with ethyl vanillate.Pediatrics, 7 1
F. Lam, S. Price (1947)
Histoplasmosis in man.Hawaii medical journal, 6 5
J. H. Seabury (1946)
In Vitro Susceptibility of Histoplasmosis to Therapeutic AgentsProc. Soc. Exper. Biol. & Med., 61
I. Snapper (1948)
Influence of 2-hydroxystilbamidine on the course of multiple myeloma.Journal of the Mount Sinai Hospital, New York, 15 3
S. Locket , E. A. Atkinson (1953)
Histoplasmosis in Great Britain: Description of a Second Case of Disseminated HistoplasmosisBrit. M. J., 2
Abstract THE TREATMENT of histoplasmosis, particularly of the progressive disseminated type, has been for the most part unsuccessful. In vitro studies by Seabury and Artis 1 revealed that stilbamidine is an effective histoplasmocidal agent, and Snapper has shown that 2-hydroxystilbamidine inhibits the growth of histoplasma capsulatum in vitro in concentrations of 20 to 40 γ per milliliter.2 Because of these findings and inferred benefit from stilbamidine in disseminated cases, we felt that a clinical trial with 2-hydroxystilbamidine was indicated in a case of localized histoplasmosis of the hard palate recently admitted to the Veterans Administration Hospital, Hines, Ill. REPORT OF A CASE A 53-year-old white man, a cattle farmer from Nebraska, first noted a painful area involving the gingiva in the region of his left upper premolar teeth in May, 1953. A small nodule developed in this area, and approximately one month after onset of symptoms it became ulcerated. At References 1. References 9 and 10. 2. Baker, L. A.; Edidin, B. D.; Kushner, D. S., and Snapper, I.: The Results of 2-Hydroxystilbamidine Therapy in Disseminated Coccidioidomycosis, unpublished data. 3. Seabury, J. H., and Artis, D.: In Vitro Susceptibility of Histoplasmosis to Therapeutic Agents , Proc. Soc. Exper. Biol. & Med. 61:15, 1946. 4. Snapper, I.; Schneid, B.; McVay, L., and Lieben, F.: Pharmacology and Therapeutic Value of Diamidine Derivatives, Particularly of 2-Hydroxystilbamidine , Tr. New York Acad. Sc. 14:269, 1952. 5. Christie, A.; Middleton, J. M.; Peterson, J. C., and McVickar, D. L.: Treatment of Disseminated Histoplasmosis with Ethyl Vanillate , Pediatrics 7:7, 1951. 6. Ellis, F. F., Jr.; Scott, J. R., and Miller, J. M.: Treatment of Progressive Disseminated Histoplasmosis with Ethyl Vanillate and Propamidine , Antibiotics & Chemother. 2:347, 1952. 7. Locket, S.; Atkinson, E. A., and Grieve, W. S. M.: Histoplasmosis in Great Britain: Description of a Second Case of Disseminated Histoplasmosis; Treatment by Ethyl Vanillate , Brit. M. J. 2:857, 1953. 8. Parsons, R. J., and Zarafonetis, C.: Histoplasmosis in Man , Arch. Int. Med. 75:1, 1945. 9. Seabury, J. H.: Stilbamidine in the Treatment of Histoplasmosis: Two Case Reports , Ann. Int. Med. 31:520, 1949. 10. Snapper, I.: Influence of 2-Hydroxystilbamidine on the Course of Multiple Myeloma , J. Mt. Sinai Hosp. 15:156, 1948. 11. Snapper, I., and McVay, L. V., Jr.: The Treatment of North America Blastomycosis with 2-Hydroxystilbamidine , Am. J. Med. 15:603, 1953. 12. Sutliff, W. D.; Kyle, J. W., and Hobson, J. L.: North American Blastomycosis: Clinical Forms of the Disease and Treatment with Stilbamidine and 2-Hydroxystilbamidine , Ann. Int. Med. 41:89, 1954.
A.M.A. Archives of Internal Medicine – American Medical Association
Published: Jan 1, 1955
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