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T. Spies, R. Stone, G. LOPEZ, F. Milanes, R. TOCA, A. Reboredo (1950)
Response to adrenocorticotropic hormone and cortisone in persons with carcinoma, leukaemia, and lymphosarcoma.Lancet, 2 6624
D. Cameron, S. Townsend, E. Mills, W. Mathews (1951)
ACTH and cortisone in the treatment of acute leukaemia.Canadian Medical Association journal, 65 6
J. Wilkinson, A. Haddow, J. Nabarro (1953)
Discussion on the Chemotherapy of the ReticulosesJournal of the Royal Society of Medicine, 46
I. Schulman, J. Lanman, O. Laxdal, L. Holt (1951)
Effects of ACTH and cortisone on leukemia in childhood.Pediatrics, 8 1
C. Gasser (1953)
Leukämie im Kindesalter unter Cortison und AminopterinHelvet. paediat. acta, 8
J. Dacie, E. Dresner, D. Mollin, J. White (1951)
Acute Leukaemia Treated with A-MethopterinBritish Medical Journal, 1
L. Davidson, R. Girdwood, H. Swan (1952)
Effect of A.C.T.H. and Cortisone Therapy in Blood DisordersBritish Medical Journal, 2
M. Sacks, G. Bradford, E. Schoenbach (1950)
The response of acute leukemia to the administration of the folic acid antagonists, aminopterin and a-methopterin; report of 14 cases.Annals of internal medicine, 32 1
(1952)
Medical Research Council, Panel on the Hematological Applications of ACTH and Cortisone: The Treatment of Blood Diseases with ACTH and Cortisone (Preliminary Report)Brit. M. J., 1
C. Smith, W. Bell (1950)
Aminopterin in treatment of leukemia in children; serial aspirations of bone marrow as a guide to management and appraisal of treatment.American journal of diseases of children, 79 6
A. Videbæk (1950)
Effects of Acth in Human LeukæmiaScandinavian Journal of Clinical & Laboratory Investigation, 2
E. H. Reisner (1950)
Blood Club ProceedingsBlood, 5
Overbeek Ga (1953)
Effects of ACTHNederlands Tijdschrift voor Geneeskunde, 97
M. Wintrobe, G. Cartwright, J. Palmer, W. Kuhns, L. Samuels (1951)
Effect of corticotrophin and cortisone on the blood in various disorders in man.A.M.A. archives of internal medicine, 88 3
J. M. Stickney (1952)
Corticotropin and Cortisone in Blood Diseases in ChildrenJ. A. M. A., 150
J. Burchenal, M. Murphy, R. Ellison, M. Sykes, T. Tan, L. Leone, D. Karnofsky, L. Craver, H. Dargeon, C. Rhoads (1953)
Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases.Blood, 8 11
Suzman Mm (1953)
The clinical application of corticotropin and cortisone therapy; a report of 247 cases.South African Medical Journal, 27
I. N. Rosenberg , A. P. Cleroux, M. S. Raben, R. W. Payne (1951)
Clinical Evaluation of Corticotropin TherapyA. M. A. Arch. Int. Med., 88
M. C. Rosenthal , R. H. Saunders, L. I.: Zannos Schwartz, E. P. Santiago (1951)
The Use of ACTH and Cortisone in the Treatment of Leukemia and LeukosarcomaBlood, 6
W. Dameshek, M. Freedman, L. Steinberg (1950)
Folic acid antagonists in the treatment of acute and subacute leukemia.Blood, 5 10
W. Adams, W. Valentine, S. Bassett, J. Lawrence (1952)
The effect of cortisone and ACTH in leukemia.The Journal of laboratory and clinical medicine, 39 4
J. D. Gray (1953)
Systemic Reticulo-Endotheliosis Terminating as a Monocytic LeukemiaCancer, 6
I. Rosenberg, A. Cléroux, M. Raben, R. Payne, E. Astwood (1951)
Clinical evaluation of corticotropin therapy.A.M.A. archives of internal medicine, 88 2
J. Wilkinson, C. Gardikas (1951)
TREATMENT OF ACUTE LEUKÆMIA WITH AMINOPTERINThe Lancet, 257
O. H. Pearson (1950)
Use of Pituitary Adrenocorticotropic Hormone (ACTH) and Cortisone in Lymphomas and LeukemiasJ. A. M. A., 144
Ellis Dresner (1951)
The Treatment of Acute LeukaemiaPostgraduate Medical Journal, 27
M. M. Wintrobe , G. E. Cartwright, J. G. Palmer, W. J. Kuhns (1951)
Effect of Corticotrophin and Cortisone on the Blood in Various Disorders in ManA. M. A. Arch. Int. Med., 88
O. Pearson, L. Eliel (1950)
Use of pituitary adrenocorticotropic hormone (ACTH) and cortisone in lymphomas and leukemias.Journal of the American Medical Association, 144 16
M. M. Wintrobe (1951)
Clinical Hematology
J. Bernard (1952)
Leucemies et glandes endocrinesSang, 23
L. W. Kinsell , H. Rogers, C. Baker (1950)
Monocytic Leukemia Treated with Pituitary Adrenocorticotropic Hormone (ACTH)J. A. M. A., 144
L. Meyer, F. Miller, M. Rowen, G. Bock, J. Rutzky (1950)
Treatment of acute leukemia with amethopterin (4-amino, 10-methyl pteroyl glutamic acid).Acta haematologica, 4 3
S. G. Taylor , J. P. Ayer (1950)
Cortical Steroids in Treatment of Cancer: Observations on Effects of Pituitary Adrenocorticotropic Hormone (ACTH) and Cortisone in Far Advanced CasesJ. A. M. A., 144
J. V. Dacie , E. Dresner, D. L. Mollin (1950)
Aminopterin in the Treatment of Acute LeukaemiaBrit. M. J., 1
H. Bierman, K. Kelly, N. Petrakis, M. Shimkin (1952)
Leukemia; duration of life in children treated with corticotropin and cortisone.California medicine, 77 4
J. F. Wilkinson (1953)
Discussion of the Chemotherapy of the ReticulosesProc. Roy. Soc. Med., 46
L. J. Witts , C. J. C. Britton, L. S. P. Davidson, L. J. Davis, A. Haddow, L. Whitby, J. F. Wilkinson (1953)
Treatment of Blood Disorders with A. C. T. H. and Cortisone: Second Report to the Medical Research Council by the Panel on the Haematological Applications of A. C. T. H. and CortisoneBrit. M. J., 2
J. M. M. Darte , C. E. Snelling, B. Laski, S. H. Jackson (1951)
ACTH and Cortisone in the Treatment of Leukaemia in ChildrenCanad. M. A. J., 65
S. Taylor, J. Ayer, R. Morris (1950)
Cortical steroids in treatment of cancer; observations on effects of pituitary adrenocorticotropic hormone (ACTH) and cortisone in far advanced cases.Journal of the American Medical Association, 144 13
G. M. Aber , G. N. Chandler (1954)
Cortisone and ACTH in Treatment of Non-Rheumatic ConditionsBrit. M. J., 1
J. Stickney, S. Mills (1952)
Corticotropin and cortisone in blood diseases in children.Journal of the American Medical Association, 150 13
S. Wilson (1951)
Observations on the effect of various folic acid antagonists on acute leukemia.Blood, 6 11
L. Kinsell, H. Rogers, C. Baker, B. Jenkins (1950)
Monocytic leukemia treated with pituitary adrenocorticotropic hormone (ACTH).Journal of the American Medical Association, 144 8
Abstract ALTHOUGH the usefulness of the hormones corticotropin and cortisone in the treatment of acute leukemia has become quite clear, little consideration has been given to the possible reasons for the effectiveness of these agents in some cases and their failure in others. We have become impressed that in certain cases the course of the illness has even seemed to become accelerated in association with such hormone therapy. A review of our own experience was therefore initiated and the present report represents the results of that study. REVIEW OF LITERATURE A review of the literature reveals that others have made somewhat similar observations, although a critical analysis of experience in a single clinic has not been published. In Table 1 a summary is given of the recorded data. Unfortunately, a number of investigators have not attempted to differentiate the various types of acute leukemia. Others have done so, but criteria for References 1. References 29-35. 2. Pearson, O. H., and Eliel, L. P.: Use of Pituitary Adrenocorticotropic Hormone (ACTH) and Cortisone in Lymphomas and Leukemias , J. A. M. A. 144:1349, 1950.Crossref 3. Spies, T. D.; Stone, R. E.; Lopez, G. G.; Milanes, F.; Toca, R. L., and Reboredo, A.: Response to Adrenocorticotropic Hormone and Cortisone in Persons with Carcinoma, Leukaemia, and Lymphosarcoma , Lancet 2:241, 1950.Crossref 4. Kinsell, L. W.; Rogers, H.; Baker, C., and Jenkins, B. J.: Monocytic Leukemia Treated with Pituitary Adrenocorticotropic Hormone (ACTH) , J. A. M. A. 144:617, 1950.Crossref 5. Videbaek, A. A.: Effects of ACTH in Human Leukaemia , Scandinav. J. Clin. & Lab. Invest. 2:276, 1950. 6. Taylor, S. G., III.; Ayer, J. P., and Morris, R. S., Jr.: Cortical Steroids in Treatment of Cancer: Observations on Effects of Pituitary Adrenocorticotropic Hormone (ACTH) and Cortisone in Far Advanced Cases , J. A. M. A. 144:1058, 1950. 7. Reisner, E. H., Jr., in discussion on Blood Club Proceedings , Blood 5:792, 1950. 8. Schulman, I.; Lanman, J. T.; Laxdal, O. E., and Holt, L. E., Jr.: Effects of ACTH and Cortisone on Leukemia in Childhood , Pediatrics 8:34, 1951. 9. Rosenberg, I. N.; Cleroux, A. P.; Raben, M. S.; Payne, R. W., and Astwood, E. B.: Clinical Evaluation of Corticotropin Therapy , A. M. A. Arch. Int. Med. 88:211, 1951. 10. Rosenthal, M. C.; Saunders, R. H.; Schwartz, L. I.: Zannos, L.; Santiago, E. P., and Dameshek, W.: The Use of ACTH and Cortisone in the Treatment of Leukemia and Leukosarcoma , Blood 6:804, 1951. 11. Cameron, D. G.; Townsend, S. R.; Mills, E. S., and Mathews, W. H.: ACTH and Cortisone in the Treatment of Acute Leukaemia , Canad. M. A. J. 65:552, 1951. 12. Darte, J. M. M.; Snelling, C. E.; Laski, B.; Jackson, S. H., and Donohue, W. L.: ACTH and Cortisone in the Treatment of Leukaemia in Children , Canad. M. A. J. 65:560, 1951. 13. Farber, S.; Downing, V.; Schwachman, H.; Toch, R.; Appleton, R.; Heald, F; King, J. P., and Feriozi, D.: The Action of ACTH and Cortisone in Acute Leukemia, in Proceedings of Second Clinical ACTH Conference, edited by J. R. Mote, Philadelphia, The Blakiston Company, 1951, Vol. 2, p. 251. 14. Pierce, M., in discussion, in Proceedings of Second Clinical ACTH Conference, edited by J. R. Mote, Philadelphia, The Blakiston Company, 1951, Vol. 2, p. 277. 15. Bethell, F. H., in discussion, in Proceedings of Second Clinical ACTH Conference, edited by J. R. Mote, Philadelphia, The Blakiston Company, 1951, Vol. 2, p. 259. 16. Adams, W. S.; Valentine, W. N.; Bassett, S. H., and Lawrence, J. S.: The Effect of Cortisone and ACTH in Leukemia , J. Lab. & Clin. Med. 39:570, 1952. 17. Bernard, J., and Bessis, M.: Leucemies et glandes endocrines , Sang 23:205, 1952. 18. Medical Research Council, Panel on the Hematological Applications of ACTH and Cortisone: The Treatment of Blood Diseases with ACTH and Cortisone (Preliminary Report) , Brit. M. J. 1:1261, 1952 19. Bierman, H. R.; Kelly, K. H.; Petrakis, N. L., and Shimkin, M. B.: Leukemia: Duration of Life in Children Treated with Corticotropin and Cortisone , California Med. 77:238, 1952. 20. Davidson, L. S. P.; Girdwood, R. H., and Swan, H. T.: Effect of ACTH and Cortisone Therapy in Blood Disorders , Brit. M. J. 2:1059, 1952. 21. Stickney, J. M., and Mills, S. D.: Corticotropin and Cortisone in Blood Diseases in Children , J. A. M. A. 150:1278, 1952. 22. Gasser, C., and Cramer, R.: Leukämie im Kindesalter unter Cortison und Aminopterin , Helvet. paediat. acta 8:10, 1953. 23. Suzman, M. M.: The Clinical Application of Corticotropin and Cortisone Therapy: A Report of 247 Cases , South African M. J. 27:195, 1953. 24. Gray, J. D., and Taylor, S.: Systemic Reticulo-Endotheliosis Terminating as a Monocytic Leukemia , Cancer 6:333, 1953. 25. Wilkinson, J. F.: Discussion of the Chemotherapy of the Reticuloses , Proc. Roy. Soc. Med. 46:685, 1953. 26. Witts, L. J.; Britton, C. J. C.; Davidson, L. S. P.; Davis, L. J.; Haddow, A.; Whitby, L.; Wilkinson, J. F., and Mollison, P. L.: Treatment of Blood Disorders with A. C. T. H. and Cortisone: Second Report to the Medical Research Council by the Panel on the Haematological Applications of A. C. T. H. and Cortisone , Brit. M. J. 2:1400, 1953.Crossref 27. Aber, G. M.; Chandler, G. N., and Hartfall, S. J.: Cortisone and ACTH in Treatment of Non-Rheumatic Conditions , Brit. M. J. 1:1, 1954.Crossref 28. Wintrobe, M. M.: Clinical Hematology , Ed. 3, Philadelphia, Lea & Febiger, 1951. 29. Wintrobe, M. M.; Cartwright, G. E.; Palmer, J. G.; Kuhns, W. J., and Samuels, L. T.: Effect of Corticotrophin and Cortisone on the Blood in Various Disorders in Man , A. M. A. Arch. Int. Med. 88:310, 1951.Crossref 30. Sacks, M. S.; Bradford, G. T., and Schoenbach, E. B.: The Response of Acute Leukemia to the Administration of the Folic Acid Antagonists, Aminopterin and Amethopterin: Report of 14 Cases , Ann. Int. Med. 32:80, 1950.Crossref 31. Smith, C. H., and Bell, W. R.: Aminopterin in Treatment of Leukemia in Children: Serial Aspirations of Bone Marrow as a Guide to Management and Appraisal of Treatment , Am. J. Dis. Child. 79:1031, 1950.Crossref 32. Dacie, J. V.; Dresner, E.; Mollin, D. L., and White, J. C.: Aminopterin in the Treatment of Acute Leukaemia , Brit. M. J. 1:1447, 1950.Crossref 33. Meyer, L. M.; Miller, F. R.; Rowen, M. J.; Bock, G., and Rutzky, J.: Treatment of Acute Leukemia with Amethopterin (4-Amino, 10-Methyl Pteroyl Glutamic Acid) , Acta haemat. 4:157, 1950.Crossref 34. Dameshek, W.; Freedman, M. H., and Steinberg, L.: Folic Acid Antagonists in the Treatment of Acute and Subacute Leukemia , Blood 5:898, 1950. 35. Wilkinson, J. F., and Gardikas, C.: Treatment of Acute Leukaemia with Aminopterin , Lancet 1:325, 1951.Crossref 36. Dacie, J. V.; Dresner, E.; Mollin, D. L., and White, J. C.: Acute Leukaemia Treated with A-Methopterin , Brit. M. J. 1:784, 1951.Crossref 37. Wilson, S. J.: Observations on the Effect of Various Folic Acid Antagonists on Acute Leukemia , Blood 6:1002, 1951. 38. Burchenal, J. H.; Murphy, M. L.; Ellison, R. R.; Sykes, M. P.; Tan, T. C.; Leone, L. A.; Karnofsky, D. A.; Craver, L. F.; Dargeon, H. W., and Rhoads, C. P.: Clinical Evaluation of a New Antimetabolite, 6-Mercaptopurine, in the Treatment of Leukemia and Allied Diseases , Blood 8:965, 1953.
A.M.A. Archives of Internal Medicine – American Medical Association
Published: Sep 1, 1954
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