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NASAL INSTILLATION AND INHALATION OF CRYSTALLINE VITAMIN B12 IN PERNICIOUS ANEMIA

NASAL INSTILLATION AND INHALATION OF CRYSTALLINE VITAMIN B12 IN PERNICIOUS ANEMIA Abstract SINCE the introduction of liver therapy by Minot and Murphy in 1926, the treatment of pernicious anemia has undergone many alterations simplifying procedures for both patient and physician. Oral administration of whole liver has been discarded because of the expense and the unpalatability of this material in sufficient quantity to be effective. Ingestion of liver extract, dessicated defatted hog stomach, liver-stomach concentrate, proteolyzed liver preparations, normal gastric juice, and vitamin B12 substances, as well as sublingual administration of vitamin B12 have not proved satisfactory for complete therapy of pernicious anemia. While folic acid corrects the hematologic disturbance, it does not favorably influence the neurological complications. The administration of massive doses of vitamin B12 by mouth produces adequate response in patients with Addisonian anemia,* but this mode of treatment is costly. Recent reports on the effectiveness of reaction products of vitamin B12 and intrinsic factor in oral therapy are encouraging although References 1. References 1 2. 2. 3. Meyer, L. M.; Sawitsky, A.; Chen, B. S.; Krim, M., and Fadem, R.: Oral Treatment of Pernicious Anemia with Vitamin B-12 , Am. J. M. Sc. 220:604, 1950.Crossref 4. Ungley, C. C.: Absorption if Vitamin B-12 in Pernicious Anemia: I. Oral Administration Without a Source of Intrinsic Factor , Brit. M. J. 2:905, 1950.Crossref 5. Spies, T. D.; Stone, R. E.; Suarez, R. M.; Garcia-Lopez, G.; Lopez-Toca, R., and Reboredo, A.: Antianemic Properties of Reaction Products of Vitamin B-12 and Intrinsic Factor , J. A. M. A. 151:1264, 1953. 6. Dautrebande, I.: Physiological and Pharmacological Characteristics of Liquid Aerosols , Physiol. Rev. 32:214, 1952. 7. Conley, C. L.; Krevans, J. R.; Chow, B. F.; Barrows, C., and Long, C. A.: Observations on the Absorption, Utilization and Excretion of B-12 , J. Lab. & Clin. Med. 38:84, 1951. 8. Monto, R. W.; Rebuck, J. W., and Brennan, M. J.: Crystalline B12 Inhalation Therapy in Pernicious Anemia , Am. J. M. Sc. 225:113, 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

NASAL INSTILLATION AND INHALATION OF CRYSTALLINE VITAMIN B12 IN PERNICIOUS ANEMIA

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1954.00240260055005
Publisher site
See Article on Publisher Site

Abstract

Abstract SINCE the introduction of liver therapy by Minot and Murphy in 1926, the treatment of pernicious anemia has undergone many alterations simplifying procedures for both patient and physician. Oral administration of whole liver has been discarded because of the expense and the unpalatability of this material in sufficient quantity to be effective. Ingestion of liver extract, dessicated defatted hog stomach, liver-stomach concentrate, proteolyzed liver preparations, normal gastric juice, and vitamin B12 substances, as well as sublingual administration of vitamin B12 have not proved satisfactory for complete therapy of pernicious anemia. While folic acid corrects the hematologic disturbance, it does not favorably influence the neurological complications. The administration of massive doses of vitamin B12 by mouth produces adequate response in patients with Addisonian anemia,* but this mode of treatment is costly. Recent reports on the effectiveness of reaction products of vitamin B12 and intrinsic factor in oral therapy are encouraging although References 1. References 1 2. 2. 3. Meyer, L. M.; Sawitsky, A.; Chen, B. S.; Krim, M., and Fadem, R.: Oral Treatment of Pernicious Anemia with Vitamin B-12 , Am. J. M. Sc. 220:604, 1950.Crossref 4. Ungley, C. C.: Absorption if Vitamin B-12 in Pernicious Anemia: I. Oral Administration Without a Source of Intrinsic Factor , Brit. M. J. 2:905, 1950.Crossref 5. Spies, T. D.; Stone, R. E.; Suarez, R. M.; Garcia-Lopez, G.; Lopez-Toca, R., and Reboredo, A.: Antianemic Properties of Reaction Products of Vitamin B-12 and Intrinsic Factor , J. A. M. A. 151:1264, 1953. 6. Dautrebande, I.: Physiological and Pharmacological Characteristics of Liquid Aerosols , Physiol. Rev. 32:214, 1952. 7. Conley, C. L.; Krevans, J. R.; Chow, B. F.; Barrows, C., and Long, C. A.: Observations on the Absorption, Utilization and Excretion of B-12 , J. Lab. & Clin. Med. 38:84, 1951. 8. Monto, R. W.; Rebuck, J. W., and Brennan, M. J.: Crystalline B12 Inhalation Therapy in Pernicious Anemia , Am. J. M. Sc. 225:113, 1953.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1954

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