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C. Conley, J. Krevans, B. Chow, C. Barrows, C. Lang (1951)
Observations on the absorption, utilization, and excretion of vitamin B12.The Journal of laboratory and clinical medicine, 38 1
C. C. Ungley (1950)
Absorption if Vitamin B-12 in Pernicious Anemia: I. Oral Administration Without a Source of Intrinsic FactorBrit. M. J., 2
T. Spies, R. Stone, R. Suárez, G. GARCIA-LOPEZ, R. Lopez-Toca (1953)
Antianemic properties of reaction products of vitamin B12 and the intrinsic factor.Journal of the American Medical Association, 151 15
L. M. Meyer , A. Sawitsky, B. S. Chen, M. Krim (1950)
Oral Treatment of Pernicious Anemia with Vitamin B-12Am. J. M. Sc., 220
C. Conley, T. Green, R. Hartmann, J. Krevans (1952)
Prolonged treatment of pernicious anemia with vitamin B12.The American journal of medicine, 13 3
L. Dautrebande (1952)
Physiological and pharmacological characteristics of liquid aerosols.Physiological reviews, 32 2
T. D. Spies , R. E. Stone, R. M. Suarez, G. Garcia-Lopez, R. Lopez-Toca (1953)
Antianemic Properties of Reaction Products of Vitamin B-12 and Intrinsic FactorJ. A. M. A., 151
R. Monto, J. Rebuck, M. Brennan (1953)
CRYSTALLINE B12 INHALATION THERAPY IN PERNICIOUS ANEMIAThe American Journal of the Medical Sciences, 225
C. L. Conley , J. R. Krevans, B. F. Chow, C. Barrows (1951)
Observations on the Absorption, Utilization and Excretion of B-12J. Lab. & Clin. Med., 38
Abstract SINCE the introduction of liver therapy by Minot and Murphy in 1926, the treatment of pernicious anemia has undergone many alterations simplifying procedures for both patient and physician. Oral administration of whole liver has been discarded because of the expense and the unpalatability of this material in sufficient quantity to be effective. Ingestion of liver extract, dessicated defatted hog stomach, liver-stomach concentrate, proteolyzed liver preparations, normal gastric juice, and vitamin B12 substances, as well as sublingual administration of vitamin B12 have not proved satisfactory for complete therapy of pernicious anemia. While folic acid corrects the hematologic disturbance, it does not favorably influence the neurological complications. The administration of massive doses of vitamin B12 by mouth produces adequate response in patients with Addisonian anemia,* but this mode of treatment is costly. Recent reports on the effectiveness of reaction products of vitamin B12 and intrinsic factor in oral therapy are encouraging although References 1. References 1 2. 2. 3. Meyer, L. M.; Sawitsky, A.; Chen, B. S.; Krim, M., and Fadem, R.: Oral Treatment of Pernicious Anemia with Vitamin B-12 , Am. J. M. Sc. 220:604, 1950.Crossref 4. Ungley, C. C.: Absorption if Vitamin B-12 in Pernicious Anemia: I. Oral Administration Without a Source of Intrinsic Factor , Brit. M. J. 2:905, 1950.Crossref 5. Spies, T. D.; Stone, R. E.; Suarez, R. M.; Garcia-Lopez, G.; Lopez-Toca, R., and Reboredo, A.: Antianemic Properties of Reaction Products of Vitamin B-12 and Intrinsic Factor , J. A. M. A. 151:1264, 1953. 6. Dautrebande, I.: Physiological and Pharmacological Characteristics of Liquid Aerosols , Physiol. Rev. 32:214, 1952. 7. Conley, C. L.; Krevans, J. R.; Chow, B. F.; Barrows, C., and Long, C. A.: Observations on the Absorption, Utilization and Excretion of B-12 , J. Lab. & Clin. Med. 38:84, 1951. 8. Monto, R. W.; Rebuck, J. W., and Brennan, M. J.: Crystalline B12 Inhalation Therapy in Pernicious Anemia , Am. J. M. Sc. 225:113, 1953.
A.M.A. Archives of Internal Medicine – American Medical Association
Published: Feb 1, 1954
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