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ACUTE INTERMITTENT PORPHYRIA: Prompt Response to Therapy with Corticotropin

ACUTE INTERMITTENT PORPHYRIA: Prompt Response to Therapy with Corticotropin Abstract THERE have been an increasing number of case reports of the hitherto comparatively been an increasing number of case reports of the hitherto comparatively rare group of disorders included under the general term of porphyria. An excellent review of the recent literature may be found in the publications of Goldman and Kaplan1 and of Calvy, Jaruszewski, and Carroll.2 In all the case reports it may be noted that the treatment of this severe disorder has been entirely nonspecific and has been directed primarily toward the correction and amelioration of the distressing symptoms of the disease, particularly pain and fluid imbalance. This report concerns itself with a case of acute intermittent porphyria of the "mixed" variety, combining the features of the light-sensitive and the acute type. It is noteworthy, as it presents the first recorded case in which dramatically successful therapy was accomplished with adrenocortical hormone. A 39-year-old Englishwoman was first References 1. Goldman, A. M., and Kaplan, M. H.: Acute Porphyria , Ann. Int. Med. 34:415-427 ( (Feb.) ) 1951.Crossref 2. Calvy, G. L.; Jaruszewski, E. J., and Carroll, H. H.: Porphyria: Clinical Observations and a Family Vignette , Ann. Int. Med. 34:767-777 ( (March) ) 1951.Crossref 3. This information was supplied by Dr. W. N. Rogers, St. Heliers Group of Hospitals, Surrey, England. 4. Oltman, J. E., and Friedman, S.: Acute Porphyria: Report of a Case Showing Ineffectiveness of ACTH , New England J. Med. 244:173-174 ( (Feb.) ) 1951.Crossref 5. Dubois, E. L.; Commons, R. R.; Starr, P.; Stein, C. S. Jr., and Morrison, R.: Corticotropin and Cortisone Treatment for Systemic Lupus Erythematosus , J. A. M. A. 149:995-1002 ( (July 12) ) 1952.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

ACUTE INTERMITTENT PORPHYRIA: Prompt Response to Therapy with Corticotropin

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1953.00240150108009
Publisher site
See Article on Publisher Site

Abstract

Abstract THERE have been an increasing number of case reports of the hitherto comparatively been an increasing number of case reports of the hitherto comparatively rare group of disorders included under the general term of porphyria. An excellent review of the recent literature may be found in the publications of Goldman and Kaplan1 and of Calvy, Jaruszewski, and Carroll.2 In all the case reports it may be noted that the treatment of this severe disorder has been entirely nonspecific and has been directed primarily toward the correction and amelioration of the distressing symptoms of the disease, particularly pain and fluid imbalance. This report concerns itself with a case of acute intermittent porphyria of the "mixed" variety, combining the features of the light-sensitive and the acute type. It is noteworthy, as it presents the first recorded case in which dramatically successful therapy was accomplished with adrenocortical hormone. A 39-year-old Englishwoman was first References 1. Goldman, A. M., and Kaplan, M. H.: Acute Porphyria , Ann. Int. Med. 34:415-427 ( (Feb.) ) 1951.Crossref 2. Calvy, G. L.; Jaruszewski, E. J., and Carroll, H. H.: Porphyria: Clinical Observations and a Family Vignette , Ann. Int. Med. 34:767-777 ( (March) ) 1951.Crossref 3. This information was supplied by Dr. W. N. Rogers, St. Heliers Group of Hospitals, Surrey, England. 4. Oltman, J. E., and Friedman, S.: Acute Porphyria: Report of a Case Showing Ineffectiveness of ACTH , New England J. Med. 244:173-174 ( (Feb.) ) 1951.Crossref 5. Dubois, E. L.; Commons, R. R.; Starr, P.; Stein, C. S. Jr., and Morrison, R.: Corticotropin and Cortisone Treatment for Systemic Lupus Erythematosus , J. A. M. A. 149:995-1002 ( (July 12) ) 1952.Crossref

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1953

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