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LACK OF INTERFERENCE OF AUREOMYCIN WITH PENICILLIN IN TREATMENT OF PNEUMOCOCCIC PNEUMONIA

LACK OF INTERFERENCE OF AUREOMYCIN WITH PENICILLIN IN TREATMENT OF PNEUMOCOCCIC PNEUMONIA Abstract CERTAIN bacteria are destroyed more slowly in vitro when exposed to the combination of penicillin and aureomycin, chlooxytetracycline ("terramycin") than when exposed to penicillin alone.1 has also been observed in experimental mouse2fections.hat received both penicillin and one of thebroad-spectrumhad a higher mortality rate than those treated with penicillin alone. Effective antibiotic blood levels were present only for a few hours, however, and in similar studies performed in our laboratory no antagonism occurred when blood levels were maintained for two or three3ys.se observations indicate that antibiotic antagonism is significant mainly during the early hours of antibiotic action and that it may be of clinical importance only when recovery depends upon the rapid destruction of bacteria. Leppe-Dowlingted a higher mortality rate for patients with pneumococcictis who received both penicillin and aureomycin than for a controlup treated with penicillin alone. Inpneumococcic, survival seems to d-end upon the rapid destruction of pneumococci, and it References 1. Jawetz, E.; Gunnison, J. B., and Coleman, V. R.: The Combined Action of Penicillin with Streptomycin or Chloromycetin on Enterococci in Vitro , Science 111:254, 1950.Crossref 2. Gunnison, J. B.; Jawetz, E., and Coleman, V. R.: The Effect of Combinations of Antibiotics on Enterococci in Vitro , J. Lab. & Clin. Med. 36:900, 1950. 3. Gunnison, J. B.; Coleman, V. R., and Jawetz, E.: Interference of Aureomycin and of Terramycin with Action of Penicillin in Vitro , Proc. Soc. Exper. Biol. & Med. 75:549, 1950. 4. Hunter, T. H.: Speculations on the Mechanism of Cure of Bacterial Endocarditis , J.A.M.A. 144:524, 1950. 5. Jawetz, E., and Speck, R. S.: Joint Action of Penicillin with Chloramphenicol on an Experimental Streptococcal Infection of Mice , Proc. Soc. Exper. Biol. & Med. 74:93, 1950. 6. Speck, R. S.; Jawerz, E., and Gunnison, J.B.: Studies on Antibiotic Synergism and Antagonism , A.M.A. Arch. Int. Med. 88:168, 1951. 7. Jawetz, E.; Gannison, J. B.; Speck, R. S., and Coleman, V. R.: Studies on Antibiotic Synergism and Antagonism , A.M.A. Arch. Int. Med. 87:349, 1951. 8. Ahern, J. J.; Burnell, J. M., and Kirby, W. M. M.: Lack of Interference of Chloramphenicol with Penicillin in a Hemolytic Streptococcal Infection in Mice , Proc. Soc. Exper. Biol. & Med. 79:568, 1952. 9. Lepper, M. H., and Dowling, H. F.: Treatment of Pneumococcic Meningitis with Penicillin Compared with Penicillin plus Aureomycin , A. M. A. Arch. Int. Med. 88:489, 1951. 10. Smith, M. R.; Perry, W. D.; Berry, J. W., and Wood, W. B., Jr.: Surface Phagocytosis in Vivo , J. Immunol. 67:71, 1951. 11. Aureomycin was supplied by the Lederletories. 12. Gocke, T. M.; Collins, H. S., and Finland, M.: Aureomycin Treatment of Pneumococcic Pneumonia , Arch. Int. Med. 84:857, 1949. 13. Dowling, H. F.; Lepper, M. H.; Hussey, H. H.; Caldwell, E. R., and Spies, H. W.: The Treatment of Pneumococcic Pneumonia with Aureomycin , J. Lab. & Clin. Med. 35:215, 1950. 14. Jackson, G. G.; Haight, T. H.; Kass, E. H.; Womack, C. R.; Gocke, T. M., and Finland, M.: Terramycin Therapy of Pneumonia: Clinical and Bacteriologic Studies in 91 Cases , Ann. Int. Med. 35:1175, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

LACK OF INTERFERENCE OF AUREOMYCIN WITH PENICILLIN IN TREATMENT OF PNEUMOCOCCIC PNEUMONIA

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1953.00240140057004
Publisher site
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Abstract

Abstract CERTAIN bacteria are destroyed more slowly in vitro when exposed to the combination of penicillin and aureomycin, chlooxytetracycline ("terramycin") than when exposed to penicillin alone.1 has also been observed in experimental mouse2fections.hat received both penicillin and one of thebroad-spectrumhad a higher mortality rate than those treated with penicillin alone. Effective antibiotic blood levels were present only for a few hours, however, and in similar studies performed in our laboratory no antagonism occurred when blood levels were maintained for two or three3ys.se observations indicate that antibiotic antagonism is significant mainly during the early hours of antibiotic action and that it may be of clinical importance only when recovery depends upon the rapid destruction of bacteria. Leppe-Dowlingted a higher mortality rate for patients with pneumococcictis who received both penicillin and aureomycin than for a controlup treated with penicillin alone. Inpneumococcic, survival seems to d-end upon the rapid destruction of pneumococci, and it References 1. Jawetz, E.; Gunnison, J. B., and Coleman, V. R.: The Combined Action of Penicillin with Streptomycin or Chloromycetin on Enterococci in Vitro , Science 111:254, 1950.Crossref 2. Gunnison, J. B.; Jawetz, E., and Coleman, V. R.: The Effect of Combinations of Antibiotics on Enterococci in Vitro , J. Lab. & Clin. Med. 36:900, 1950. 3. Gunnison, J. B.; Coleman, V. R., and Jawetz, E.: Interference of Aureomycin and of Terramycin with Action of Penicillin in Vitro , Proc. Soc. Exper. Biol. & Med. 75:549, 1950. 4. Hunter, T. H.: Speculations on the Mechanism of Cure of Bacterial Endocarditis , J.A.M.A. 144:524, 1950. 5. Jawetz, E., and Speck, R. S.: Joint Action of Penicillin with Chloramphenicol on an Experimental Streptococcal Infection of Mice , Proc. Soc. Exper. Biol. & Med. 74:93, 1950. 6. Speck, R. S.; Jawerz, E., and Gunnison, J.B.: Studies on Antibiotic Synergism and Antagonism , A.M.A. Arch. Int. Med. 88:168, 1951. 7. Jawetz, E.; Gannison, J. B.; Speck, R. S., and Coleman, V. R.: Studies on Antibiotic Synergism and Antagonism , A.M.A. Arch. Int. Med. 87:349, 1951. 8. Ahern, J. J.; Burnell, J. M., and Kirby, W. M. M.: Lack of Interference of Chloramphenicol with Penicillin in a Hemolytic Streptococcal Infection in Mice , Proc. Soc. Exper. Biol. & Med. 79:568, 1952. 9. Lepper, M. H., and Dowling, H. F.: Treatment of Pneumococcic Meningitis with Penicillin Compared with Penicillin plus Aureomycin , A. M. A. Arch. Int. Med. 88:489, 1951. 10. Smith, M. R.; Perry, W. D.; Berry, J. W., and Wood, W. B., Jr.: Surface Phagocytosis in Vivo , J. Immunol. 67:71, 1951. 11. Aureomycin was supplied by the Lederletories. 12. Gocke, T. M.; Collins, H. S., and Finland, M.: Aureomycin Treatment of Pneumococcic Pneumonia , Arch. Int. Med. 84:857, 1949. 13. Dowling, H. F.; Lepper, M. H.; Hussey, H. H.; Caldwell, E. R., and Spies, H. W.: The Treatment of Pneumococcic Pneumonia with Aureomycin , J. Lab. & Clin. Med. 35:215, 1950. 14. Jackson, G. G.; Haight, T. H.; Kass, E. H.; Womack, C. R.; Gocke, T. M., and Finland, M.: Terramycin Therapy of Pneumonia: Clinical and Bacteriologic Studies in 91 Cases , Ann. Int. Med. 35:1175, 1951.

Journal

A.M.A. Archives of Internal Medicine – American Medical Association

Published: Feb 1, 1953

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