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BARBITURATE POISONING: Report of Three Cases

BARBITURATE POISONING: Report of Three Cases Abstract INCIDENCE The POPULARITY of the barbiturates with the medical profession and the laity has contributed greatly to the pronounced rise in the rate of poisonings and deaths due to their use. In 1946 the city hospitals of New York were reporting 1 death every thirtysix hours due to this type of drug.1Of the many barbituric acid derivatives which have been made and introduced to the medical profession, about twenty are used in clinical medicine today. Estimates have indicated that 230,000 pounds of barbiturates were manufactured in 1936, whereas 550,000 pounds, or more than twice as much, were produced in 1945.1 This alone is indicative of the tremendous increase in the use of these drugs.As each new drug is developed and detailed to the medical profession, it tends to enjoy a period of popularity. In 1936, the fashionable drug to use was phenobarbital or pentobarbital sodium; in References 1. Goldstein, S. W.: Barbiturates: Blessing and Menace , J. Am. Pharm. A. (Scient. Ed.) 36:5-14 ( (Jan.) ) 1947.Crossref 2. Hambourger, W. E.: The Promiscuous Use of Barbiturates: Analysis of Hospital Data , J. A. M. A. 114:2015-2019 ( (May 18) ) 1940. 3. Frankenstein, H.: Personal communication to the authors. 4. Weiss, S.: The Indications and Dangers of Sedatives and Hypnotics with Special References to the Barbituric Acid Derivatives , Internat. Clin. 1:38-66 ( (March) ) 1936. 5. Weiss.4 6. Goodman, L., and Gilman, A.: The Pharmacological Basis of Therapeutics , New York, The Macmillan Company, 1941, p. 145. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

BARBITURATE POISONING: Report of Three Cases

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1949 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1949.00230030021002
Publisher site
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Abstract

Abstract INCIDENCE The POPULARITY of the barbiturates with the medical profession and the laity has contributed greatly to the pronounced rise in the rate of poisonings and deaths due to their use. In 1946 the city hospitals of New York were reporting 1 death every thirtysix hours due to this type of drug.1Of the many barbituric acid derivatives which have been made and introduced to the medical profession, about twenty are used in clinical medicine today. Estimates have indicated that 230,000 pounds of barbiturates were manufactured in 1936, whereas 550,000 pounds, or more than twice as much, were produced in 1945.1 This alone is indicative of the tremendous increase in the use of these drugs.As each new drug is developed and detailed to the medical profession, it tends to enjoy a period of popularity. In 1936, the fashionable drug to use was phenobarbital or pentobarbital sodium; in References 1. Goldstein, S. W.: Barbiturates: Blessing and Menace , J. Am. Pharm. A. (Scient. Ed.) 36:5-14 ( (Jan.) ) 1947.Crossref 2. Hambourger, W. E.: The Promiscuous Use of Barbiturates: Analysis of Hospital Data , J. A. M. A. 114:2015-2019 ( (May 18) ) 1940. 3. Frankenstein, H.: Personal communication to the authors. 4. Weiss, S.: The Indications and Dangers of Sedatives and Hypnotics with Special References to the Barbituric Acid Derivatives , Internat. Clin. 1:38-66 ( (March) ) 1936. 5. Weiss.4 6. Goodman, L., and Gilman, A.: The Pharmacological Basis of Therapeutics , New York, The Macmillan Company, 1941, p. 145.

Journal

Archives of Internal Medicine – American Medical Association

Published: Sep 1, 1949

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