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RADIOACTIVE ISOTOPES IN THE STUDY OF PERIPHERAL VASCULAR DISEASE: I. Derivation of a Circulatory Index

RADIOACTIVE ISOTOPES IN THE STUDY OF PERIPHERAL VASCULAR DISEASE: I. Derivation of a Circulatory... Abstract THE APPLICATION of a new investigative tool in medical research is an exciting experience. Old concepts and barriers to new ideas crumble, and new avenues of approach to the understanding and solution of previously impenetrable problems appear. We are reporting on the use of radioactive isotopes in the investigation of peripheral vascular diseases, especially arteriosclerosis obliterans. The gradual aging of the population has increased the incidence of arteriosclerosis and its complications and will undoubtedly continue to do so. One such factor, recently enunciated, has been the progressive development of obliterative vascular diseases in diabetic patients, whose lives have now been prolonged by approximately a generation through the judicious use of insulin. The frequent occurrence of advanced vascular disease among patients at Cook County Hospital and the resulting necessity for amputations prompted this investigation. In the past several years, a number of reports1 have appeared on the use of various References 1. Katz, R. A.: Impending Ischemic Gangrene: New Non Surgical Therapeutic Suggestions (Preliminary Report) , New Orleans M. & S. J. 98:542-555 ( (June) ) 1946. 2. Wirtschafter, Z. T., and Widmann, R.: Elaboration of Histamine in Vivo in the Treatment of Peripheral Vascular Disorders: Preliminary Report , J. A. M. A. 133:604-605 ( (March 1) ) 1947. 3. Berry, R. L.; Campbell, K. N.; Lyons, R. H.; Moe, G. K., and Sutler, M. R.: Use of Tetraethylammonium in Peripheral Vascular Disease and Causalgic States: New Method for Producing Blockade of Autonomic Ganglia , Surgery 20:525-535 ( (Oct.) ) 1946. 4. Ochsner, A., and DeBakey, M.: Peripheral Vascular Disease: Classification and Therapeusis Based upon Physio-Pathologic Alterations , Internat. Clin. 3:1-32 ( (Sept.) ) 1939. 5. Allen, E. V.; Barker, N. W., and Hines, E. A., Jr.: Peripheral Vascular Diseases , Philadelphia, W. B. Saunders Co., 1946, p. 380. 6. Quimby, E. H., and Smith, B. C.: Tracer Studies with Radioactive Sodium in Patients with Peripheral Vascular Disease , Science 100:175-177 ( (Aug. 25) ) 1944. 7. Smith, B. C., and Quimby, E. H.: Use of Radioactive Sodium in Studies of Circulation in Patients with Peripheral Vascular Disease: Preliminary Report , Surg., Gynec. & Obst. 79:142-147 ( (Aug.) ) 1944 8. Use of Radioactive Sodium as Tracer in Study of Peripheral Vascular Disease , Radiology 45:335-346 ( (Oct.) ) 1945. 9. Quimby, E. H.: Radioactive Sodium as a Tool in Medical Research , Am. J. Roentgenol. 58:741-753 ( (Dec.) ) 1947. 10. Blumgart, H. L., and Yens, O. C.: Studies on Velocity of Blood Flow: Method Utilized , J. Clin. Investigation 4:1-13 ( (April) ) 1927. 11. Blumgart, H. L., and Weiss, S.: Studies on Velocity of Blood Flow: Pulmonary Circulation Time in Normal Resting Individuals , J. Clin. Investigation 4:399-425 ( (Aug.) ) 1927. 12. McCracken, E. C.; Essex, H, E., and Sheard, C.: Circulation Time of Blood of Dogs, Determined by Ionization (Geiger Counter) Methods: Effects of Physicophysiological Agents and of Drugs , Am. Heart J. 14:51-59 ( (July) ) 1937. 13. McCracken, E. C.; Sheard, C., and Essex, H. E.: Ensemble for Determination of Circulation Time of Blood by Ionization (Geiger Chamber) Method , Proc. Soc. Exper. Biol. & Med. 36:106-110 ( (March) ) 1937. 14. Hubbard, J. P.; Preston, W. N., and Ross, R. A.: Velocity of Blood Flow in Infants and Young Children Determined by Radioactive Sodium , J. Clin. Investigation 21:613-617 ( (Sept.) ) 1942. 15. Friedell, M. T.; Drucker, E. F., and Pickett, W. J.: Histidine and Ascorbic Acid Treatment of Arteriosclerosis Obliterans, with Radioactive Isotope Estimations of Circulatory Effects , J. A. M. A. 138:1036-1039 ( (Dec. 4) ) 1948. 16. Evans, R. D.: Tissue Dosage in Radio-Isotope Therapy , Am. J. Roentgenol. 58:754-756 ( (Dec.) ) 1947. 17. Ricker, G.: Die Entstehung der pathologisch-anatomischen befunde nach Hirnerschütterung in Abhängigkeit vom Gefässnervensystem des Hirnes , Virchows Arch. f. path. Anat. 226:180-212, 1919. 18. Nedzel, A. S.: Vascular Spasm: Experimental Studies, Illinois Medical and Dental Monographs, vol. 3, nos. 3 and 4, 1943. 19. Lange, K., and Boyd, L. J.: Functional Pathology of Experimental Frostbite and Prevention of Subsequent Gangrene , Surg., Gynec. & Obst. 80:346-350 ( (April) ) 1945. 20. Scheinker, I. M.: Vasoparalysis of Central Nervous System, Characteristic Vascular Syndrome: Significance in Pathology of Central Nervous System , Arch. Neurol. & Psychiat. 52:43-56 ( (July) ) 1944. 21. Gilbert, N. C., and de Takats, G.: Emergency Treatment of Apoplexy , J. A. M. A. 136:659-665 ( (March 6) ) 1948. 22. Peterson, cited by Nedzel.11 23. Schaffner, F.; Friedell, M. T.; Pickett, W. J., and Hummon I. F. Jr.; Radioactive Isotopes in the Study of Peripheral Vascular Disease: II. Method of Evaluation of Various Forms of Treatment , Arch. Int. Med. , to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

RADIOACTIVE ISOTOPES IN THE STUDY OF PERIPHERAL VASCULAR DISEASE: I. Derivation of a Circulatory Index

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References (26)

Publisher
American Medical Association
Copyright
Copyright © 1949 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1949.00220350018002
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Abstract

Abstract THE APPLICATION of a new investigative tool in medical research is an exciting experience. Old concepts and barriers to new ideas crumble, and new avenues of approach to the understanding and solution of previously impenetrable problems appear. We are reporting on the use of radioactive isotopes in the investigation of peripheral vascular diseases, especially arteriosclerosis obliterans. The gradual aging of the population has increased the incidence of arteriosclerosis and its complications and will undoubtedly continue to do so. One such factor, recently enunciated, has been the progressive development of obliterative vascular diseases in diabetic patients, whose lives have now been prolonged by approximately a generation through the judicious use of insulin. The frequent occurrence of advanced vascular disease among patients at Cook County Hospital and the resulting necessity for amputations prompted this investigation. In the past several years, a number of reports1 have appeared on the use of various References 1. Katz, R. A.: Impending Ischemic Gangrene: New Non Surgical Therapeutic Suggestions (Preliminary Report) , New Orleans M. & S. J. 98:542-555 ( (June) ) 1946. 2. Wirtschafter, Z. T., and Widmann, R.: Elaboration of Histamine in Vivo in the Treatment of Peripheral Vascular Disorders: Preliminary Report , J. A. M. A. 133:604-605 ( (March 1) ) 1947. 3. Berry, R. L.; Campbell, K. N.; Lyons, R. H.; Moe, G. K., and Sutler, M. R.: Use of Tetraethylammonium in Peripheral Vascular Disease and Causalgic States: New Method for Producing Blockade of Autonomic Ganglia , Surgery 20:525-535 ( (Oct.) ) 1946. 4. Ochsner, A., and DeBakey, M.: Peripheral Vascular Disease: Classification and Therapeusis Based upon Physio-Pathologic Alterations , Internat. Clin. 3:1-32 ( (Sept.) ) 1939. 5. Allen, E. V.; Barker, N. W., and Hines, E. A., Jr.: Peripheral Vascular Diseases , Philadelphia, W. B. Saunders Co., 1946, p. 380. 6. Quimby, E. H., and Smith, B. C.: Tracer Studies with Radioactive Sodium in Patients with Peripheral Vascular Disease , Science 100:175-177 ( (Aug. 25) ) 1944. 7. Smith, B. C., and Quimby, E. H.: Use of Radioactive Sodium in Studies of Circulation in Patients with Peripheral Vascular Disease: Preliminary Report , Surg., Gynec. & Obst. 79:142-147 ( (Aug.) ) 1944 8. Use of Radioactive Sodium as Tracer in Study of Peripheral Vascular Disease , Radiology 45:335-346 ( (Oct.) ) 1945. 9. Quimby, E. H.: Radioactive Sodium as a Tool in Medical Research , Am. J. Roentgenol. 58:741-753 ( (Dec.) ) 1947. 10. Blumgart, H. L., and Yens, O. C.: Studies on Velocity of Blood Flow: Method Utilized , J. Clin. Investigation 4:1-13 ( (April) ) 1927. 11. Blumgart, H. L., and Weiss, S.: Studies on Velocity of Blood Flow: Pulmonary Circulation Time in Normal Resting Individuals , J. Clin. Investigation 4:399-425 ( (Aug.) ) 1927. 12. McCracken, E. C.; Essex, H, E., and Sheard, C.: Circulation Time of Blood of Dogs, Determined by Ionization (Geiger Counter) Methods: Effects of Physicophysiological Agents and of Drugs , Am. Heart J. 14:51-59 ( (July) ) 1937. 13. McCracken, E. C.; Sheard, C., and Essex, H. E.: Ensemble for Determination of Circulation Time of Blood by Ionization (Geiger Chamber) Method , Proc. Soc. Exper. Biol. & Med. 36:106-110 ( (March) ) 1937. 14. Hubbard, J. P.; Preston, W. N., and Ross, R. A.: Velocity of Blood Flow in Infants and Young Children Determined by Radioactive Sodium , J. Clin. Investigation 21:613-617 ( (Sept.) ) 1942. 15. Friedell, M. T.; Drucker, E. F., and Pickett, W. J.: Histidine and Ascorbic Acid Treatment of Arteriosclerosis Obliterans, with Radioactive Isotope Estimations of Circulatory Effects , J. A. M. A. 138:1036-1039 ( (Dec. 4) ) 1948. 16. Evans, R. D.: Tissue Dosage in Radio-Isotope Therapy , Am. J. Roentgenol. 58:754-756 ( (Dec.) ) 1947. 17. Ricker, G.: Die Entstehung der pathologisch-anatomischen befunde nach Hirnerschütterung in Abhängigkeit vom Gefässnervensystem des Hirnes , Virchows Arch. f. path. Anat. 226:180-212, 1919. 18. Nedzel, A. S.: Vascular Spasm: Experimental Studies, Illinois Medical and Dental Monographs, vol. 3, nos. 3 and 4, 1943. 19. Lange, K., and Boyd, L. J.: Functional Pathology of Experimental Frostbite and Prevention of Subsequent Gangrene , Surg., Gynec. & Obst. 80:346-350 ( (April) ) 1945. 20. Scheinker, I. M.: Vasoparalysis of Central Nervous System, Characteristic Vascular Syndrome: Significance in Pathology of Central Nervous System , Arch. Neurol. & Psychiat. 52:43-56 ( (July) ) 1944. 21. Gilbert, N. C., and de Takats, G.: Emergency Treatment of Apoplexy , J. A. M. A. 136:659-665 ( (March 6) ) 1948. 22. Peterson, cited by Nedzel.11 23. Schaffner, F.; Friedell, M. T.; Pickett, W. J., and Hummon I. F. Jr.; Radioactive Isotopes in the Study of Peripheral Vascular Disease: II. Method of Evaluation of Various Forms of Treatment , Arch. Int. Med. , to be published.

Journal

Archives of Internal Medicine – American Medical Association

Published: Jun 1, 1949

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