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CRITICAL STATISTICAL ANALYSIS OF DATA ON RENAL FUNCTION IN GROUPED SUBJECTS WITH ESSENTIAL HYPERTENSION

CRITICAL STATISTICAL ANALYSIS OF DATA ON RENAL FUNCTION IN GROUPED SUBJECTS WITH ESSENTIAL... Abstract We have made a statistical study of the renal function of patients with essential hypertension. The only large series of data available to us from tests of renal function are chiefly results of the Volhard, the phenolsulfonphthalein excretion and the urea clearance test. It has been shown by a number of investigators1 that these tests do not demonstrate remarkable reductions in renal function in persons with essential hypertension. On studying the reports on which this con clusion was based, it was evident that the opinion was obtained as a result of comparing single examples of renal function in persons with essential hypertension with single examples of renal function in a normal person in an attempt to demonstrate differential diagnostic possibilities of the tests. We have tried other methods of analysis in order to exhaust the possibilities of these tests. The purpose of this paper is to demonstrate that References 1. Leiter, L.: Renal Function in Studies from the Lasker Foundation for Medical Research, Chicago, 1930-1937, vol. 1, no. 10. 2. Pratt, J. H.: Dilution and Concentration Tests of Renal Function , Boston M. & S. J. 195:203-207 ( (July 29) ) 1926. 3. Ellis, L. B., and Weiss, S.: Normal Variations in Renal Function with a Discussion of Their Physiological Significance , Am. J. M. Sc. 186:233-242, 1933 4. Renal Function in Persons with One Kidney , Ellis Am. J. M. Sc. 186: 242-248, 1933 5. Renal Function in Arterial Hypertension , J. A. M. A. 100: 875-878 ( (March 25) ) 1933. 6. Chapman, E. M., and Halstead, J. A.: Fractional Phenolsulphonphthalein Test in Bright's Disease , Am. J. M. Sc. 186:223-232, 1933. 7. Van Slyke, D. D.; Stillman, E.; Modler, E.; Ehrich, W.; McIntosh, J. F.; Leiter, L.; Mackon, E. M.; Hannon, R. R., and Moore, N. S.: Observation on the Course of Different Types of Bright's Disease and on the Resultant Change in Renal Anatomy , Medicine 9:257-386, 1930. 8. Kisch, F.: Essential Hypertension and the Kidneys , Wien. Arch. f. inn. Med. 9:1, 1925 9. abstracted, J. A. M. A. 84:239 ( (Jan. 17) ) 1925. 10. Major, R. H.: Renal Function in Arterial Hypertension , Am. J. M. Sc. 176:637-644, 1928. 11. Musser, J. H., and Phillips, A. W.: A Comparison of Blood Pressure, Blood Urea Nitrogen, Phenolsulphonephthalein and Urine Tests in the Aged , J. Lab. & Clin. Med. 15:632-637, 1930. 12. Buck, R. W., and Proger, S. H.: Dilution and Concentration Test of Renal Function , New England J. Med. 203:1283-1288 ( (Dec. 25) ) 1930. 13. Freyberg, R. H.: The Choice and Interpretation of Tests of Renal Efficiency , J. A. M. A. 105:1575-1580 ( (Nov. 16) ) 1935. 14. Dalton, J. W., and Nuzum, F. R.: Some Evidence of Impaired Function of the Kidney in Individuals with Essential Hypertension , Proc. Sixth Pacific Sc. Cong. , to be published. 15. Rountree, L. G., and Geraghty, J. T.: An Experimental and Clinical Study of the Functional Activity of the Kidneys by Means of Phenolsulphonephthalein , J. Pharmacol. & Exper. Therap. 1:579-661, 1910. 16. Møller, E.; McIntosh, J. F., and Van Slyke, D. D.: Studies in Urea Excretion: II. Relationship Between Urine Volume and the Rate of Urea Excretion by Normal Adults , J. Clin. Investigation 6:427-465, 1928. 17. Volhard, F., and Suter, F.: Nieren und ableitende Harnwege , Berlin, Julius Springer, 1931, p. 165. 18. Fisher, R. A.: Statistical Methods for Research Workers , London, Oliver & Boyd, 1930, p. 46. 19. Burn, J. H.: Errors in Biological Assay , Physiol. Rev. 10:165, 1930. 20. Fisher,6 p. 107. 21. Fisher,6 pp. 101-102. 22. Burn,7 p. 168. 23. Nuzum, F. R.; Sansum, W. D., and Osborne, M.: The Experimental Production of Hypertension , Arch. Int. Med. 35:497-499 ( (April) ) 1925. 24. Fisher,6 pp. 101-102. 25. Lucia, S. P.: Personal communication to the authors. 26. Lashmet, F. H., and Newburgh, J. H.: A Comparative Study of the Excretion of Water and Solids by Normal and Abnormal Kidneys , J. Clin. Investigation 11:1003-1010, 1932. 27. Dubois, E. F.: Basal Metabolism in Health and Disease , ed. 3, Philadelphia, Lea & Febiger, 1936, p. 446. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

CRITICAL STATISTICAL ANALYSIS OF DATA ON RENAL FUNCTION IN GROUPED SUBJECTS WITH ESSENTIAL HYPERTENSION

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References (17)

Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1942.00200240032003
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Abstract

Abstract We have made a statistical study of the renal function of patients with essential hypertension. The only large series of data available to us from tests of renal function are chiefly results of the Volhard, the phenolsulfonphthalein excretion and the urea clearance test. It has been shown by a number of investigators1 that these tests do not demonstrate remarkable reductions in renal function in persons with essential hypertension. On studying the reports on which this con clusion was based, it was evident that the opinion was obtained as a result of comparing single examples of renal function in persons with essential hypertension with single examples of renal function in a normal person in an attempt to demonstrate differential diagnostic possibilities of the tests. We have tried other methods of analysis in order to exhaust the possibilities of these tests. The purpose of this paper is to demonstrate that References 1. Leiter, L.: Renal Function in Studies from the Lasker Foundation for Medical Research, Chicago, 1930-1937, vol. 1, no. 10. 2. Pratt, J. H.: Dilution and Concentration Tests of Renal Function , Boston M. & S. J. 195:203-207 ( (July 29) ) 1926. 3. Ellis, L. B., and Weiss, S.: Normal Variations in Renal Function with a Discussion of Their Physiological Significance , Am. J. M. Sc. 186:233-242, 1933 4. Renal Function in Persons with One Kidney , Ellis Am. J. M. Sc. 186: 242-248, 1933 5. Renal Function in Arterial Hypertension , J. A. M. A. 100: 875-878 ( (March 25) ) 1933. 6. Chapman, E. M., and Halstead, J. A.: Fractional Phenolsulphonphthalein Test in Bright's Disease , Am. J. M. Sc. 186:223-232, 1933. 7. Van Slyke, D. D.; Stillman, E.; Modler, E.; Ehrich, W.; McIntosh, J. F.; Leiter, L.; Mackon, E. M.; Hannon, R. R., and Moore, N. S.: Observation on the Course of Different Types of Bright's Disease and on the Resultant Change in Renal Anatomy , Medicine 9:257-386, 1930. 8. Kisch, F.: Essential Hypertension and the Kidneys , Wien. Arch. f. inn. Med. 9:1, 1925 9. abstracted, J. A. M. A. 84:239 ( (Jan. 17) ) 1925. 10. Major, R. H.: Renal Function in Arterial Hypertension , Am. J. M. Sc. 176:637-644, 1928. 11. Musser, J. H., and Phillips, A. W.: A Comparison of Blood Pressure, Blood Urea Nitrogen, Phenolsulphonephthalein and Urine Tests in the Aged , J. Lab. & Clin. Med. 15:632-637, 1930. 12. Buck, R. W., and Proger, S. H.: Dilution and Concentration Test of Renal Function , New England J. Med. 203:1283-1288 ( (Dec. 25) ) 1930. 13. Freyberg, R. H.: The Choice and Interpretation of Tests of Renal Efficiency , J. A. M. A. 105:1575-1580 ( (Nov. 16) ) 1935. 14. Dalton, J. W., and Nuzum, F. R.: Some Evidence of Impaired Function of the Kidney in Individuals with Essential Hypertension , Proc. Sixth Pacific Sc. Cong. , to be published. 15. Rountree, L. G., and Geraghty, J. T.: An Experimental and Clinical Study of the Functional Activity of the Kidneys by Means of Phenolsulphonephthalein , J. Pharmacol. & Exper. Therap. 1:579-661, 1910. 16. Møller, E.; McIntosh, J. F., and Van Slyke, D. D.: Studies in Urea Excretion: II. Relationship Between Urine Volume and the Rate of Urea Excretion by Normal Adults , J. Clin. Investigation 6:427-465, 1928. 17. Volhard, F., and Suter, F.: Nieren und ableitende Harnwege , Berlin, Julius Springer, 1931, p. 165. 18. Fisher, R. A.: Statistical Methods for Research Workers , London, Oliver & Boyd, 1930, p. 46. 19. Burn, J. H.: Errors in Biological Assay , Physiol. Rev. 10:165, 1930. 20. Fisher,6 p. 107. 21. Fisher,6 pp. 101-102. 22. Burn,7 p. 168. 23. Nuzum, F. R.; Sansum, W. D., and Osborne, M.: The Experimental Production of Hypertension , Arch. Int. Med. 35:497-499 ( (April) ) 1925. 24. Fisher,6 pp. 101-102. 25. Lucia, S. P.: Personal communication to the authors. 26. Lashmet, F. H., and Newburgh, J. H.: A Comparative Study of the Excretion of Water and Solids by Normal and Abnormal Kidneys , J. Clin. Investigation 11:1003-1010, 1932. 27. Dubois, E. F.: Basal Metabolism in Health and Disease , ed. 3, Philadelphia, Lea & Febiger, 1936, p. 446.

Journal

Archives of Internal Medicine – American Medical Association

Published: Dec 1, 1942

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