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FUNCTION OF THE SEPARATE KIDNEYS IN HYPERTENSIVE SUBJECTS

FUNCTION OF THE SEPARATE KIDNEYS IN HYPERTENSIVE SUBJECTS Abstract The presence of a unilateral pyelographic abnormality in a hypertensive subject has been accepted as having etiologic significance, the assumption being that an abnormal pyelogram is indicative of a pathologic change resulting in obstruction to the renal blood flow and that the resulting ischemic renal tissue is responsible for elevated blood pressure. This report is concerned with the correlation of pyelography and renal function in the separate kidneys of 21 hypertensive subjects. In addition, the effect on renal function of operative procedures designed to increase the renal blood flow will be reported for a small group of hypertensive subjects. SELECTION OF SUBJECTS Twenty-one subjects with well established essential hypertension were chosen at random from the hypertension and nephritis clinic of the New York University Medical Clinic and from the wards of the Third (New York University) Medical Division of Bellevue Hospital, without regard to the presence or absence of signs References 1. Smith, H. W.; Goldring, W., and Chasis, H.: Measurement of the Tubular Mass, Effective Blood Flow and Filtration Rate in the Normal Human Kidney , J. Clin. Investigation 17:263-278 ( (May) ) 1938.Crossref 2. Chasis, H., and Redish, J.: Renal Blood Flow in the Separate Kidneys of Hypertensive Subjects , J. Clin. Investigation 20:655-661 ( (Nov.) ) 1941.Crossref 3. Goldring, W.; Chasis, H.; Ranges, H. A., and Smith, H. W.: Relations of Effective Renal Blood Flow and Glomerular Filtration to Tubular Excretory Mass in Normal Man , J. Clin. Investigation 19:737-750 ( (Sept.) ) 1940.Crossref 4. By dividing the filtration rate (inulin clearance, CIn) by the renal plasma flow (CD) the fraction of plasma filtered (filtration fraction) through the glomerulus can be determined. 5. Thompson, G. J., and Bumpus, H. C.: Ureteral Kinks , J. A. M. A. 94: 771-773 ( (March 15) ) 1930.Crossref 6. As urologists well know, retrograde, as compared to intravenous, pyelography throws little light on the functional status of the kidneys. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

FUNCTION OF THE SEPARATE KIDNEYS IN HYPERTENSIVE SUBJECTS

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1942.00200230051004
Publisher site
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Abstract

Abstract The presence of a unilateral pyelographic abnormality in a hypertensive subject has been accepted as having etiologic significance, the assumption being that an abnormal pyelogram is indicative of a pathologic change resulting in obstruction to the renal blood flow and that the resulting ischemic renal tissue is responsible for elevated blood pressure. This report is concerned with the correlation of pyelography and renal function in the separate kidneys of 21 hypertensive subjects. In addition, the effect on renal function of operative procedures designed to increase the renal blood flow will be reported for a small group of hypertensive subjects. SELECTION OF SUBJECTS Twenty-one subjects with well established essential hypertension were chosen at random from the hypertension and nephritis clinic of the New York University Medical Clinic and from the wards of the Third (New York University) Medical Division of Bellevue Hospital, without regard to the presence or absence of signs References 1. Smith, H. W.; Goldring, W., and Chasis, H.: Measurement of the Tubular Mass, Effective Blood Flow and Filtration Rate in the Normal Human Kidney , J. Clin. Investigation 17:263-278 ( (May) ) 1938.Crossref 2. Chasis, H., and Redish, J.: Renal Blood Flow in the Separate Kidneys of Hypertensive Subjects , J. Clin. Investigation 20:655-661 ( (Nov.) ) 1941.Crossref 3. Goldring, W.; Chasis, H.; Ranges, H. A., and Smith, H. W.: Relations of Effective Renal Blood Flow and Glomerular Filtration to Tubular Excretory Mass in Normal Man , J. Clin. Investigation 19:737-750 ( (Sept.) ) 1940.Crossref 4. By dividing the filtration rate (inulin clearance, CIn) by the renal plasma flow (CD) the fraction of plasma filtered (filtration fraction) through the glomerulus can be determined. 5. Thompson, G. J., and Bumpus, H. C.: Ureteral Kinks , J. A. M. A. 94: 771-773 ( (March 15) ) 1930.Crossref 6. As urologists well know, retrograde, as compared to intravenous, pyelography throws little light on the functional status of the kidneys.

Journal

Archives of Internal Medicine – American Medical Association

Published: Nov 1, 1942

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