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UTILITY OF THE CONGO RED TEST IN DIAGNOSIS AND IN DIFFERENTIAL DIAGNOSIS

UTILITY OF THE CONGO RED TEST IN DIAGNOSIS AND IN DIFFERENTIAL DIAGNOSIS Abstract During the past few years the congo red test for the confirmation of amyloid deposits in the body has been serviceable in our hands in elucidating the nature of obscure enlargements of the spleen and the liver. Since this test is not as well known as it deserves to be, and since we feel that many problems in diagnosis might be clarified by its use, reports are presented of 7 cases in which this test was of great value in arriving at a diagnosis. It should be emphasized that if positive, the information derived from the test is unequivocal, but there may be a small to moderate degree of amyloid present, undetectable by the test. Bennhold1 found that congo red, if carefully prepared, could be injected intravenously without danger. He presented 10 cases demonstrating that amyloid deposits in the liver would remove the dye rapidly from the circulating blood. References 1. Bennhold, H.: Ueber die Beziehungen des Kongorotes zur amyloiden Substanz und über den Mechanismus der beschleunigten Farbstoffausscheidung bei tubulären Nierenkrankheiten , Klin. Wchnschr. 3:1711,1924Crossref 2. Ueber die Ausscheidung intravenös einverleibten Kongorotes bei den verscheidensten Erkrankungen insbesondere bei Amyloidosis , Deutsches Arch. f. klin. Med. 142:32, 1923. 3. Bookman, A., and Rosenthal, J.: The Clinical Value of Intravenous Injection of Congo Red in the Diagnosis of Amyloid Disease , Am. J. M. Sc. 173: 396, 1927.Crossref 4. Barker, N. W., and Snell, A. N.: The Congo Red Test with Special Reference to Excretion of the Dye in the Urine , J. Lab. & Clin. Med. 16:262, 1930. 5. Shapiro, P. F.: Lipoid Nephrosis: Pathology, Genesis and Relation to Amyloidosis , Arch. Int. Med. 46:137 ( (July) ) 1930. 6. Wallace, J.: Diagnosis of Amyloid Disease by the Intravenous Injection of Congo Red , Lancet 1:391, 1932. 7. Rosenblatt, M.: The Clinical Manifestations of Amyloidosis , Ann. Int. Med. 8:678, 1934 8. Amyloidosis and Amyloid Nephrosis , Am. J. M. Sc. 186:558, 1933. 9. Lipstein, S., and Auerbach, O.: An Evaluation of the Congo Red Test for Amyloidosis , Quart. Bull., Sea View Hosp. 2:120, 1937. 10. Harmon, P. H., and Kernwein, G.: Congo Red Test for Amyloid Disease: A Quantitative Technic , Arch. Int. Med. , this issue, p. 416. 11. Nathan, M.: Ueber die klinische Diagnose des Amyloidose mittels Kongorotinjectionen , München. med. Wchnschr. 75:1883, 1928. 12. Strasser, U.: Die Kongorotprobe auf Amyloid bei nephrotischen Symptomencomplex , Med. Klin. 25:468, 1929. 13. Shapiro.2c 14. Leiter, L.: Nephrosis , Medicine 10:135, 1931. 15. McClure, W. B.; de Takáts, C. B., and Hinman, W. F.: Mechanism of Edema of the Renal Type , Arch. Int. Med. 51:819 ( (June) ) 1933. 16. Bennhold.1 17. Footnote 2. 18. Grayzel, H. G., and Jacobi, M.: Secondary Amyloidosis: Results of Therapy with Desiccated Whole Liver Powder , Ann. Int. Med. 12:39, 1938. 19. Whitbeck, B. H.: Liver Meal in the Treatment of Amyloidosis , J. Bone & Joint Surg. 14:85, 1932. 20. Waldenström, H.: On the Formation and Disappearance of Amyloid in Man , Acta chir. Scandinav. 63:479, 1928 21. Ueber das Entstehen und Verschwinden des Amyloids beim Menschen , Klin. Wchnschr. 6:2235, 1927. 22. Pearlman, A. W.: Regression of Amyloidosis , Quart. Bull., Sea View Hosp. 6:92, 1940. 23. Habein, H. C.: Amyloidosis: Report of a Case in Which the Patient Recovered , Proc. Staff Meet., Mayo Clin. 9:261, 1934. 24. Rosenblatt, M. B.: Recovery from Generalized Amyloidosis Secondary to Pulmonary Tuberculosis , Arch. Int. Med. 57:562 ( (March) ) 1936. 25. Reimann, H. A.: Recovery from Amyloidosis , J. A. M. A. 104:1070 ( (March 30) ) 1935.Crossref 26. Gardner, W., cited by Pearlman.10 27. Kretzschmar, P. H., and Westbrook, B. P., cited by Pearlman.10 28. Owen, I., cited by Pearlman.10 29. Walker, G. F., cited by Pearlman.10 30. Rosenblum, A. H., and Kirshbaum, J. D.: Multiple Myelomas with Tumor-Like Amyloidosis , J. A. M. A. 106:988 ( (March 21) ) 1936.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

UTILITY OF THE CONGO RED TEST IN DIAGNOSIS AND IN DIFFERENTIAL DIAGNOSIS

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References (29)

Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1942.00200210076006
Publisher site
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Abstract

Abstract During the past few years the congo red test for the confirmation of amyloid deposits in the body has been serviceable in our hands in elucidating the nature of obscure enlargements of the spleen and the liver. Since this test is not as well known as it deserves to be, and since we feel that many problems in diagnosis might be clarified by its use, reports are presented of 7 cases in which this test was of great value in arriving at a diagnosis. It should be emphasized that if positive, the information derived from the test is unequivocal, but there may be a small to moderate degree of amyloid present, undetectable by the test. Bennhold1 found that congo red, if carefully prepared, could be injected intravenously without danger. He presented 10 cases demonstrating that amyloid deposits in the liver would remove the dye rapidly from the circulating blood. References 1. Bennhold, H.: Ueber die Beziehungen des Kongorotes zur amyloiden Substanz und über den Mechanismus der beschleunigten Farbstoffausscheidung bei tubulären Nierenkrankheiten , Klin. Wchnschr. 3:1711,1924Crossref 2. Ueber die Ausscheidung intravenös einverleibten Kongorotes bei den verscheidensten Erkrankungen insbesondere bei Amyloidosis , Deutsches Arch. f. klin. Med. 142:32, 1923. 3. Bookman, A., and Rosenthal, J.: The Clinical Value of Intravenous Injection of Congo Red in the Diagnosis of Amyloid Disease , Am. J. M. Sc. 173: 396, 1927.Crossref 4. Barker, N. W., and Snell, A. N.: The Congo Red Test with Special Reference to Excretion of the Dye in the Urine , J. Lab. & Clin. Med. 16:262, 1930. 5. Shapiro, P. F.: Lipoid Nephrosis: Pathology, Genesis and Relation to Amyloidosis , Arch. Int. Med. 46:137 ( (July) ) 1930. 6. Wallace, J.: Diagnosis of Amyloid Disease by the Intravenous Injection of Congo Red , Lancet 1:391, 1932. 7. Rosenblatt, M.: The Clinical Manifestations of Amyloidosis , Ann. Int. Med. 8:678, 1934 8. Amyloidosis and Amyloid Nephrosis , Am. J. M. Sc. 186:558, 1933. 9. Lipstein, S., and Auerbach, O.: An Evaluation of the Congo Red Test for Amyloidosis , Quart. Bull., Sea View Hosp. 2:120, 1937. 10. Harmon, P. H., and Kernwein, G.: Congo Red Test for Amyloid Disease: A Quantitative Technic , Arch. Int. Med. , this issue, p. 416. 11. Nathan, M.: Ueber die klinische Diagnose des Amyloidose mittels Kongorotinjectionen , München. med. Wchnschr. 75:1883, 1928. 12. Strasser, U.: Die Kongorotprobe auf Amyloid bei nephrotischen Symptomencomplex , Med. Klin. 25:468, 1929. 13. Shapiro.2c 14. Leiter, L.: Nephrosis , Medicine 10:135, 1931. 15. McClure, W. B.; de Takáts, C. B., and Hinman, W. F.: Mechanism of Edema of the Renal Type , Arch. Int. Med. 51:819 ( (June) ) 1933. 16. Bennhold.1 17. Footnote 2. 18. Grayzel, H. G., and Jacobi, M.: Secondary Amyloidosis: Results of Therapy with Desiccated Whole Liver Powder , Ann. Int. Med. 12:39, 1938. 19. Whitbeck, B. H.: Liver Meal in the Treatment of Amyloidosis , J. Bone & Joint Surg. 14:85, 1932. 20. Waldenström, H.: On the Formation and Disappearance of Amyloid in Man , Acta chir. Scandinav. 63:479, 1928 21. Ueber das Entstehen und Verschwinden des Amyloids beim Menschen , Klin. Wchnschr. 6:2235, 1927. 22. Pearlman, A. W.: Regression of Amyloidosis , Quart. Bull., Sea View Hosp. 6:92, 1940. 23. Habein, H. C.: Amyloidosis: Report of a Case in Which the Patient Recovered , Proc. Staff Meet., Mayo Clin. 9:261, 1934. 24. Rosenblatt, M. B.: Recovery from Generalized Amyloidosis Secondary to Pulmonary Tuberculosis , Arch. Int. Med. 57:562 ( (March) ) 1936. 25. Reimann, H. A.: Recovery from Amyloidosis , J. A. M. A. 104:1070 ( (March 30) ) 1935.Crossref 26. Gardner, W., cited by Pearlman.10 27. Kretzschmar, P. H., and Westbrook, B. P., cited by Pearlman.10 28. Owen, I., cited by Pearlman.10 29. Walker, G. F., cited by Pearlman.10 30. Rosenblum, A. H., and Kirshbaum, J. D.: Multiple Myelomas with Tumor-Like Amyloidosis , J. A. M. A. 106:988 ( (March 21) ) 1936.Crossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Sep 1, 1942

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