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TRANSFUSION OF CONDITIONED UNIVERSAL BLOOD: CLINICAL OBSERVATIONS

TRANSFUSION OF CONDITIONED UNIVERSAL BLOOD: CLINICAL OBSERVATIONS Abstract The practice of transfusing blood of group O (IV Moss) to persons belonging to any of the various blood groups is based on the assumption that cells of group O are not hemolyzed or agglutinated by any normal human plasma. The concept of a universal donor as developed by Ottenberg about thirty years ago has had considerable practical application, supported mainly on the theory that the dilution of a donor's blood and the absorption of the isoagglutinins anti-A and anti-B in a patient's plasma and tissue cells would tend to prevent any significant hemolysis or agglutination. While some institutions with large transfusion services are using blood from universal donors without observing an undue reaction rate, hemolytic and other reactions have been reported after transfusion of such blood. They may vary through all degrees of severity, and a good number of representative cases have been reported in the literature. In an References 1. Gresse, E. R.: Ueber die Verwendung des sogenannter Universalspenders bei der Bluttransfusion , Deutsche Ztschr. f. Chir. 245:371, 1935.Crossref 2. Hemolytic Shock After Blood Transfusion, editorial , J. A. M. A. 106:2241 ( (June 27) ) 1936. 3. Witebsky, E.; Klendshoj, N. C., and Swanson, P.: Reduction or Elimination of the Anti-A Antibody in O Blood by Means of the Addition of the A Specific Substance , J. Infect. Dis. 67:188 ( (Nov.-Dec.) ) 1940Crossref 4. Preparation and Transfusion of Safe Universal Blood , J. A. M. A. 116:2654 ( (June 14) ) 1941.Crossref 5. Landsteiner, K.: Note on the Group-Specific Substance of Horse Saliva , Science 76:351 ( (Oct. 14) ) 1932.Crossref 6. Goebel, W. F.: The Isolation of the Blood Group A Specific Substance from Commercial Peptone , J. Exper. Med. 68:221 ( (Aug. 1) ) 1938.Crossref 7. Witebsky, E., and Klendshoj, N. C.: The Isolation of the Blood Group-Specific B Substance , J. Exper. Med. 72:663 ( (Dec.) ) 1940.Crossref 8. In our hospital intravenous therapy, including blood transfusions, is given by members of the department of anesthesia. Dr. Paul Searles, the head of this department, cooperated with us. 9. Part of this material was prepared and made available to us by Eli Lilly & Co. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

TRANSFUSION OF CONDITIONED UNIVERSAL BLOOD: CLINICAL OBSERVATIONS

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1942.00200190011001
Publisher site
See Article on Publisher Site

Abstract

Abstract The practice of transfusing blood of group O (IV Moss) to persons belonging to any of the various blood groups is based on the assumption that cells of group O are not hemolyzed or agglutinated by any normal human plasma. The concept of a universal donor as developed by Ottenberg about thirty years ago has had considerable practical application, supported mainly on the theory that the dilution of a donor's blood and the absorption of the isoagglutinins anti-A and anti-B in a patient's plasma and tissue cells would tend to prevent any significant hemolysis or agglutination. While some institutions with large transfusion services are using blood from universal donors without observing an undue reaction rate, hemolytic and other reactions have been reported after transfusion of such blood. They may vary through all degrees of severity, and a good number of representative cases have been reported in the literature. In an References 1. Gresse, E. R.: Ueber die Verwendung des sogenannter Universalspenders bei der Bluttransfusion , Deutsche Ztschr. f. Chir. 245:371, 1935.Crossref 2. Hemolytic Shock After Blood Transfusion, editorial , J. A. M. A. 106:2241 ( (June 27) ) 1936. 3. Witebsky, E.; Klendshoj, N. C., and Swanson, P.: Reduction or Elimination of the Anti-A Antibody in O Blood by Means of the Addition of the A Specific Substance , J. Infect. Dis. 67:188 ( (Nov.-Dec.) ) 1940Crossref 4. Preparation and Transfusion of Safe Universal Blood , J. A. M. A. 116:2654 ( (June 14) ) 1941.Crossref 5. Landsteiner, K.: Note on the Group-Specific Substance of Horse Saliva , Science 76:351 ( (Oct. 14) ) 1932.Crossref 6. Goebel, W. F.: The Isolation of the Blood Group A Specific Substance from Commercial Peptone , J. Exper. Med. 68:221 ( (Aug. 1) ) 1938.Crossref 7. Witebsky, E., and Klendshoj, N. C.: The Isolation of the Blood Group-Specific B Substance , J. Exper. Med. 72:663 ( (Dec.) ) 1940.Crossref 8. In our hospital intravenous therapy, including blood transfusions, is given by members of the department of anesthesia. Dr. Paul Searles, the head of this department, cooperated with us. 9. Part of this material was prepared and made available to us by Eli Lilly & Co.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jul 1, 1942

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