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DIFFUSION OF SULFANILAMIDE INTO ARTIFICIAL PERITONEAL FLUID

DIFFUSION OF SULFANILAMIDE INTO ARTIFICIAL PERITONEAL FLUID Abstract It is commonly believed that sulfanilamide compounds diffuse readily from the blood into the tissue fluids and that an equilibrium between these two mediums is established rapidly. In commenting on this phenomenon, the majority of authors refer to the observations of Marshall and Long,1 which led to the conclusion that the distribution of sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine) between the blood and the tissues is "complete or nearly complete in five to ten minutes" after its administration intravenously. This conclusion was based on the observation that the most marked decrease in the concentration of sulfapyridine in the blood occurred during the first five to ten minutes, with only a relatively slight drop during the next hour. Review of their data, however, reveals that few determinations were made five and ten minutes after the compound was administered and that in the majority of instances sulfapyridine was present in the blood (and presumably in References 1. Marshall, E. K., Jr., and Long, P. H.: The Intravenous Use of Sodium Sulfapyridine , J. A. M. A. 112:1671 ( (April 29) ) 1939.Crossref 2. Marshall, E. K., Jr.; Emerson, K., Jr., and Cutting, W. C.: Para-Aminobenzenesulfonamide: Absorption and Excretion; Method of Determination in Urine and Blood , J. A. M. A. 108:953 ( (March 20) ) 1937.Crossref 3. Nathanson, M. H.: Diffusion of Sulfonamide Compounds into the Human Pericardium , J. A. M. A. 116:280 ( (Jan. 25) ) 1941.Crossref 4. Bellows, J., and Chinn, H.: The Distribution of Sulfanilamide in the Eye , J. A. M. A. 112:2023 ( (May 20) ) 1939.Crossref 5. Marshall, E. K., Jr.; Emerson, K., Jr., and Cutting, W. C.: Distribution of Sulfanilamide in the Organism , J. Pharmacol. & Exper. Therap. 61:196 ( (Oct.) ) 1937. 6. Sadusk, J. F., Jr.; Blake, F. G., and Seymour, A.: Observations on the Absorption, Excretion, Diffusion, and Acetylation of Sulfathiazole in Man , Yale J. Biol. & Med. 12:681 ( (July) ) 1940. 7. Bratton, A. C., and Marshall, E. K., Jr.: A New Coupling Component for Sulfanilamide Determination , J. Biol. Chem. 128:537 ( (May) ) 1939. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

DIFFUSION OF SULFANILAMIDE INTO ARTIFICIAL PERITONEAL FLUID

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1942.00200150089008
Publisher site
See Article on Publisher Site

Abstract

Abstract It is commonly believed that sulfanilamide compounds diffuse readily from the blood into the tissue fluids and that an equilibrium between these two mediums is established rapidly. In commenting on this phenomenon, the majority of authors refer to the observations of Marshall and Long,1 which led to the conclusion that the distribution of sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine) between the blood and the tissues is "complete or nearly complete in five to ten minutes" after its administration intravenously. This conclusion was based on the observation that the most marked decrease in the concentration of sulfapyridine in the blood occurred during the first five to ten minutes, with only a relatively slight drop during the next hour. Review of their data, however, reveals that few determinations were made five and ten minutes after the compound was administered and that in the majority of instances sulfapyridine was present in the blood (and presumably in References 1. Marshall, E. K., Jr., and Long, P. H.: The Intravenous Use of Sodium Sulfapyridine , J. A. M. A. 112:1671 ( (April 29) ) 1939.Crossref 2. Marshall, E. K., Jr.; Emerson, K., Jr., and Cutting, W. C.: Para-Aminobenzenesulfonamide: Absorption and Excretion; Method of Determination in Urine and Blood , J. A. M. A. 108:953 ( (March 20) ) 1937.Crossref 3. Nathanson, M. H.: Diffusion of Sulfonamide Compounds into the Human Pericardium , J. A. M. A. 116:280 ( (Jan. 25) ) 1941.Crossref 4. Bellows, J., and Chinn, H.: The Distribution of Sulfanilamide in the Eye , J. A. M. A. 112:2023 ( (May 20) ) 1939.Crossref 5. Marshall, E. K., Jr.; Emerson, K., Jr., and Cutting, W. C.: Distribution of Sulfanilamide in the Organism , J. Pharmacol. & Exper. Therap. 61:196 ( (Oct.) ) 1937. 6. Sadusk, J. F., Jr.; Blake, F. G., and Seymour, A.: Observations on the Absorption, Excretion, Diffusion, and Acetylation of Sulfathiazole in Man , Yale J. Biol. & Med. 12:681 ( (July) ) 1940. 7. Bratton, A. C., and Marshall, E. K., Jr.: A New Coupling Component for Sulfanilamide Determination , J. Biol. Chem. 128:537 ( (May) ) 1939.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1942

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